What is the NOAEL for Diethylamino hydroxybenzoyl hexyl benzoate?
Diethylamino hydroxybenzoyl hexyl benzoate has 100 NOAEL studies in the database. The lowest reported value is 10 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Diethylamino hydroxybenzoyl hexyl benzoate
Also known as: UNII-ANQ870JD20, Benzoic acid, 2-(4-(diethylamino)-2-hydroxybenzoyl)-, hexyl ester, Hexyl 2-(4-(diethylamino)-2-hydroxybenzoyl)benzoate, Uvinul A Plus
CAS 302776-68-7
Diethylamino hydroxybenzoyl hexyl benzoate (CAS 302776-68-7) is a chemical substance. Key regulatory status: REACH registered, 3 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, SCCS, ECHA REACH.
View cosmetic safety profile for Diethylamino Hydroxybenzoyl Hexyl Benzoate →
SOURCE
noael studies public
NOAEL studies
100
SOURCE
chemical inventory jurisdictions
Regulatory lists
3
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
10 fields
Name
Diethylamino hydroxybenzoyl hexyl benzoate
CAS Number
302776-68-7
DTXSID
DTXSID60184370
Molecular Formula
C24H31NO4
InChI Key
FDATWRLUYRHCJE-UHFFFAOYSA-N
Monoisotopic Mass
397.225308
Synonyms
UNII-ANQ870JD20Benzoic acid, 2-(4-(diethylamino)-2-hydroxybenzoyl)-, hexyl esterHexyl 2-(4-(diethylamino)-2-hydroxybenzoyl)benzoateUvinul A Plus
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
5 records
UV stabilizerFragrance
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
3 records
| List | Keyword | Source |
|---|---|---|
| Europe; Personal care | European Commission | CosIng |
| IFRA Transparency | IFRA | IFRA |
| Canada; pharmaceutical | DrugBank | DrugBank |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 50 of 100 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 200 | mg/kg | - | oral | rat | UnifiedCodex:SCCNFP:beta.noael_studies |
| 1350 | mg/kg bw | - | oral | rat | UnifiedCodex:SCCNFP:beta.noael_studies |
| =10 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| ANQ870JD20 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| ANQ870JD20 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| ANQ870JD20 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| ANQ870JD20 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 1000 | mg/kg bw/day | LOAEL | oral | rat | COSMOS_DB |
| =-1 | - | NOAEL | - | rat | SCCS_vision_codex |
| =-1 | - | NOAEL | - | rat | SCCS_vision_codex |
| =-1 | - | NOAEL | - | rat | SCCS_vision_codex |
| =-1 | - | NOAEL | - | rat | SCCS_vision_codex |
| =0.025 | mg/kg bw/d | NOAEL | oral | - | SCCS_vision_codex |
| =0.025 | mg/kg bw/d | NOAEL | oral | - | SCCS_vision_codex |
| =0.025 | mg/kg bw/d | NOAEL | oral | - | SCCS_vision_codex |
| =0.025 | mg/kg bw/d | NOAEL | oral | - | SCCS_vision_codex |
| =0.09 | mg/kg bw/d | NOAEL | oral | rat | SCCS_vision_codex |
| =0.09 | mg/kg bw/d | NOAEL | oral | rat | SCCS_vision_codex |
| =0.09 | mg/kg bw/d | NOAEL | oral | rat | SCCS_vision_codex |
| =0.09 | mg/kg bw/d | NOAEL | oral | rat | SCCS_vision_codex |
| =0.093 | mg/kg | NOAEL | oral | rat | SCCS_vision_codex |
| =0.093 | mg/kg | NOAEL | oral | rat | SCCS_vision_codex |
| =0.093 | mg/kg | NOAEL | oral | rat | SCCS_vision_codex |
| =0.093 | mg/kg | NOAEL | oral | rat | SCCS_vision_codex |
| =0.1 | µg/cm | NOAEL | oral | rat | SCCNFP_vision_codex |
| =0.1 | µg/cm | NOAEL | oral | rat | SCCNFP_vision_codex |
| =0.1 | µg/cm | NOAEL | oral | rat | SCCNFP_vision_codex |
| =0.1 | µg/cm | NOAEL | oral | rat | SCCNFP_vision_codex |
| =2.5 | mg/kg bw/d | NOAEL | oral | - | SCCS_vision_codex |
| =2.5 | mg/kg bw/d | NOAEL | oral | - | SCCS_vision_codex |
| =2.5 | mg/kg bw/d | NOAEL | oral | - | SCCS_vision_codex |
| =2.5 | mg/kg bw/d | NOAEL | oral | - | SCCS_vision_codex |
| =5 | mg/kg bw/d | NOAEL | oral | rat | SCCS_vision_codex |
| =5 | mg/kg bw/d | NOAEL | oral | rat | SCCS_vision_codex |
| =5 | mg/kg bw/d | NOAEL | oral | rat | SCCS_vision_codex |
| =5 | mg/kg bw/d | NOAEL | oral | rat | SCCS_vision_codex |
| =18 | - | NOAEL | - | rat | SCCS_vision_codex |
| =18 | - | NOAEL | - | rat | SCCS_vision_codex |
| =18 | - | NOAEL | - | rat | SCCS_vision_codex |
| =18 | - | NOAEL | - | rat | SCCS_vision_codex |
| =20 | mg/kg bw/day | NOAEL | - | - | SCCS_vision_codex |
| =20 | mg/kg bw/day | NOAEL | - | - | SCCS_vision_codex |
| =20 | mg/kg bw/day | NOAEL | - | - | SCCS_vision_codex |
| =20 | mg/kg bw/day | NOAEL | - | - | SCCS_vision_codex |
| =50 | % | NOAEL | oral | - | SCCS_vision_codex |
| =50 | % | NOAEL | oral | - | SCCS_vision_codex |
| =50 | % | NOAEL | oral | - | SCCS_vision_codex |
| =50 | % | NOAEL | oral | - | SCCS_vision_codex |
| =100 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| 200 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
Showing 50 of 100 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Benzoic acid, 2-[4-(diethylamino)-2-hydroxybenzoyl]-, hexyl ester | 443-860-6 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed_with_terms
SCCS Opinions
EU Scientific Committee opinions tied to the matched substance.
SOURCE
EU SCCS
3 opinions
| Opinion | Date | Conclusion | Max Conc. | Concerns |
|---|---|---|---|---|
| SCCS/1678/25 | 26 June 2025 | safe with restrictions | up to 10% (DHHB); DnHexP impurity max 0.026% (260 ppm) if unavoidable; target 1 ppm | DnHexP contaminant (possible phthalate metabolite) in production process; DnHexP detected in children's urine; impurity control required |
| SCCP/1133/07 | 15 April 2008 | safe | up to 10% | Earlier opinion confirming safety at 10%; precedes the DnHexP contamination concern raised in SCCS/1678/25 |
| SCCP/0936/05 | 20 June 2006 | safe | up to 10% | Early safety assessment confirming no significant concerns at 10%; no endocrine or genotoxicity concerns at time of opinion |
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
10%
Category
sunscreen
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
diethylamino hydroxybenzoyl hexyl benzoate
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
0
Frequently Asked Questions
What regulatory lists include Diethylamino hydroxybenzoyl hexyl benzoate?
Diethylamino hydroxybenzoyl hexyl benzoate appears on 3 regulatory/inventory lists including Europe; Personal care, IFRA Transparency, Canada; pharmaceutical. Source: EPA CPDat.
Is Diethylamino hydroxybenzoyl hexyl benzoate used in cosmetics?
Yes, Diethylamino hydroxybenzoyl hexyl benzoate is also indexed as a cosmetic ingredient under the name Diethylamino Hydroxybenzoyl Hexyl Benzoate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Diethylamino hydroxybenzoyl hexyl benzoate come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Is Diethylamino hydroxybenzoyl hexyl benzoate used outside industrial chemicals?
Diethylamino hydroxybenzoyl hexyl benzoate also appears in cosmetics, pharmaceutical databases.