NOAEL Data REACH Registered Cosmetic Ingredient

Diethylamino hydroxybenzoyl hexyl benzoate

Also known as: UNII-ANQ870JD20, Benzoic acid, 2-(4-(diethylamino)-2-hydroxybenzoyl)-, hexyl ester, Hexyl 2-(4-(diethylamino)-2-hydroxybenzoyl)benzoate, Uvinul A Plus

CAS 302776-68-7

Diethylamino hydroxybenzoyl hexyl benzoate (CAS 302776-68-7) is a chemical substance. Key regulatory status: REACH registered, 3 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, SCCS, ECHA REACH.

View cosmetic safety profile for Diethylamino Hydroxybenzoyl Hexyl Benzoate →

SOURCE NOAEL studies
NOAEL studies
31
SOURCE Chemical inventory jurisdictions
Regulatory lists
3
SOURCE EU CLP Annex VI
GHS signal
Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 9 fields
Name
Diethylamino hydroxybenzoyl hexyl benzoate
CAS Number
302776-68-7
Molecular Formula
C24H31NO4
InChI Key
FDATWRLUYRHCJE-UHFFFAOYSA-N
Monoisotopic Mass
397.225308
Synonyms
UNII-ANQ870JD20Benzoic acid, 2-(4-(diethylamino)-2-hydroxybenzoyl)-, hexyl esterHexyl 2-(4-(diethylamino)-2-hydroxybenzoyl)benzoateUvinul A Plus

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 5 records
UV stabilizerFragrance

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 3 records
ListKeywordSource
Europe; Personal careEuropean CommissionCosIng
IFRA TransparencyIFRAIFRA
Canada; pharmaceuticalDrugBankDrugBank

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 31 of 31 studies
ValueUnitEndpointRouteSpeciesSource
200mg/kg-oralratRegulatory source
1350mg/kg bw-oralratRegulatory source
=10mg/m3DNEL systemicinhalationHumanToxValDB GESTIS DNEL
ANQ870JD20UNIIFDA UNII substance identifier--openFDA substances
1000mg/kg bw/dayLOAELoralratCOSMOS DB
=-1-NOAEL-ratSCCS Opinion
=0.025mg/kg bw/dNOAELoral-SCCS Opinion
=0.09mg/kg bw/dNOAELoralratSCCS Opinion
=0.093mg/kgNOAELoralratSCCS Opinion
=0.1µg/cmNOAELoralratSCCNFP Opinion
=2.5mg/kg bw/dNOAELoral-SCCS Opinion
=5mg/kg bw/dNOAELoralratSCCS Opinion
=18-NOAEL-ratSCCS Opinion
=20mg/kg bw/dayNOAEL--SCCS Opinion
=50%NOAELoral-SCCS Opinion
=100mg/kg bw/dayNOAELoralRatECHA
200mg/kg bw/dayNOAELoralratCOSMOS DB
=200mg/kg bw/dayNOAELoralRatECHA
=200mg/kg bw/dNOAELoral-SCCS Opinion
=200mg/kgNOAELoralratSCCS Opinion
=200mg/kg bw/dayNOAELoral-SCCS Opinion
=200mg/kg bwNOAELoralratSCCS Opinion
=200mg/kg bw/dayNOAELoral-SCCNFP Opinion
=200mg/kgNOAELoralratSCCNFP Opinion
=250mg/kg bw/dNOAELoralratSCCS Opinion
=300mg/kg bw/dayNOAELoralRatECHA
>=1000mg/kg bw/dayNOAELoralRatECHA
=1000mg/kg bw/dNOAELoral-SCCS Opinion
>1000mg/kg bw/dayNOAELoralpigSCCNFP Opinion
>1000mg/kg bwNOAELoralratSCCNFP Opinion
=1350mg/kg bwNOAELoralratSCCNFP Opinion

Showing 31 of 31 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA 1 records
StatusNameEC NumberLink
RegisteredBenzoic acid, 2-[4-(diethylamino)-2-hydroxybenzoyl]-, hexyl ester443-860-6ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records
Inventory Status
listed_with_terms

SCCS Opinions

EU Scientific Committee opinions tied to the matched substance.

SOURCE SCCS Opinion 5 opinions
OpinionDateConclusionMax Conc.Concerns
SCCS/1678/2526 June 2025safe with restrictionsup to 10% (DHHB); DnHexP impurity max 0.026% (260 ppm) if unavoidable; target 1 ppmDnHexP contaminant (possible phthalate metabolite) in production process; DnHexP detected in children's urine; impurity control required
SCCP/1166/0830 September 2008insufficient data-genotoxicity clarification needed; impurity concerns
SCCP/1133/0715 April 2008safeup to 10%Earlier opinion confirming safety at 10%; precedes the DnHexP contamination concern raised in SCCS/1678/25
SCCP/0936/0520 June 2006safeup to 10%Early safety assessment confirming no significant concerns at 10%; no endocrine or genotoxicity concerns at time of opinion
SCCP/0996/062006-06-20Although this substance is presently permitted and used as a sunscreen, the SCCP is of the opinion that the information submitted is not conform to current standards and guidelines for the safety evaluation of cosmetic ingredients. Before any further consideration, the following information is required:10% (requested, in sunscreen products alone or in combination with other UV absorbers; and requested up to 10% in other cosmetic products)Information submitted not conform to current standards and guidelines for safety evaluation of cosmetic ingredients; further information required before any consideration.

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB
EU Status
permitted
Max
10%
Category
sunscreen
View full cosmetic safety profile →

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE ChEMBL / DailyMed diethylamino hydroxybenzoyl hexyl benzoate
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
0
View full pharmaceutical profile →

Frequently Asked Questions

What is the NOAEL for Diethylamino hydroxybenzoyl hexyl benzoate?

Diethylamino hydroxybenzoyl hexyl benzoate has 31 NOAEL studies in the database. The lowest reported value is -1 mg/kg bw/day in rat. Source: SCCS Opinion.

What regulatory lists include Diethylamino hydroxybenzoyl hexyl benzoate?

Diethylamino hydroxybenzoyl hexyl benzoate appears on 3 regulatory/inventory lists including Europe; Personal care, IFRA Transparency, Canada; pharmaceutical. Source: EPA CPDat.

Is Diethylamino hydroxybenzoyl hexyl benzoate used in cosmetics?

Yes, Diethylamino hydroxybenzoyl hexyl benzoate is also indexed as a cosmetic ingredient under the name Diethylamino Hydroxybenzoyl Hexyl Benzoate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for Diethylamino hydroxybenzoyl hexyl benzoate come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.

Is Diethylamino hydroxybenzoyl hexyl benzoate used outside industrial chemicals?

Diethylamino hydroxybenzoyl hexyl benzoate also appears in cosmetics, pharmaceutical databases.