Danger GHS07GHS05GHS09 NOAEL Data REACH Registered Cosmetic Ingredient

5,6-Dihydroxyindole

Also known as: UNII-Z3OC8499KG, Dopamine lutine

CAS 3131-52-0

5,6-Dihydroxyindole (CAS 3131-52-0) is a chemical substance with GHS signal word Danger; key hazard signal: H302; H318; H411. Key regulatory status: REACH registered, 1 regulatory/inventory list, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, SCCS, ECHA REACH.

View cosmetic safety profile for DIHYDROXYINDOLE →

SOURCE NOAEL studies
NOAEL studies
34
SOURCE Chemical inventory jurisdictions
Regulatory lists
1
SOURCE EU CLP Annex VI
GHS signal
Danger

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 7 fields
Name
5,6-Dihydroxyindole
CAS Number
3131-52-0
Molecular Formula
C8H7NO2
InChI Key
SGNZYJXNUURYCH-UHFFFAOYSA-N
Monoisotopic Mass
149.047678
Synonyms
UNII-Z3OC8499KGDopamine lutine

GHS / CLP Classification

EU harmonized hazard classification, hazard statements, pictograms, and signal word.

SOURCE EU CLP Annex VI (ECHA) 1 classifications
Hazard ClassH-StatementsPictogramsSignal
Acute Tox. 4 *; Eye Dam. 1; Aquatic Chronic 2H302; H318; H411GHS07; GHS05; GHS09Danger

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 2 records
Dye

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 1 records
ListKeywordSource
Europe; Personal care; restrictedEuropean CommissionCosIng

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 34 of 34 studies
ValueUnitEndpointRouteSpeciesSource
1.5mg/kg bw/d---Regulatory source
3mg/kg/day--ratRegulatory source
3mg/kg-oralratRegulatory source
3mg/kg bw/day--ratRegulatory source
10mg/kg bw/day-oralratRegulatory source
10mg/kg bw/day--ratRegulatory source
Z3OC8499KGUNIIFDA UNII substance identifier--openFDA substances
10mg/kg bw/dayLOAELoralratCOSMOS DB
=0.012mg/kgNOAELdermalratSCCS Opinion
=1.5mg/kg bw/dNOAEL--SCCS Opinion
=1.5mg/kgNOAELdermalratSCCS Opinion
3mg/kg bw/dayNOAELoralratCOSMOS DB
=3mg/kg bw/dayNOAEL-ratSCCS Opinion
=3mg/kg bw/dayNOAELdermalratSCCNFP Opinion
=3mg/kgNOAELoralratSCCNFP Opinion
=3mg/kg/dayNOAEL-ratSCCNFP Opinion
=10mg/kg bw/dayNOAEL-ratSCCS Opinion
=10mg/kg bw/dayNOAELdermalratSCCNFP Opinion
=15mg/kg bw/dNOAELdermalratSCCS Opinion
=100mg/kg bw/dayNOAEL-ratSCCS Opinion
=100mg/kg bw/dayNOAEL-ratSCCNFP Opinion
=500mg/kg bwNOAELoralratSCCS Opinion
=0.012mg/kgdermal absorptiondermalratRegulatory source
=1.5mg/kgdermal absorptiondermalratRegulatory source
=3mg/kgdermal absorptionoralratRegulatory source
3mg/kg bw/daydevelopmental toxicity-ratRegulatory source
10mg/kg bw/daydevelopmental toxicityoralratRegulatory source
100mg/kg bw/daydevelopmental toxicity-ratRegulatory source
3mg/kg bw/dayrepeated dose toxicitydermalratRegulatory source
10mg/kg bw/dayrepeated dose toxicitydermalratRegulatory source
10mg/kg bw/dayrepeated dose toxicityoralratRegulatory source
500mg/kg bwrepeated dose toxicityoralratRegulatory source
15mg/kg bw/dreproductive toxicitydermalratRegulatory source
100mg/kg bw/dayreproductive toxicity-ratRegulatory source

Showing 34 of 34 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA 1 records
StatusNameEC NumberLink
Registered5,6-dihydroxyindole412-130-9ECHA overview →

SCCS Opinions

EU Scientific Committee opinions tied to the matched substance.

SOURCE SCCS Opinion 2 opinions
OpinionDateConclusionMax Conc.Concerns
SCCP/0914/0528 March 2006insufficient data-insufficient genotoxicity and toxicological data
SCCP/0952/052006-03-28Based on the information provided, the SCCP is of the opinion that the use of dihydroxyindole itself as a hair dye at a maximum concentration of 0.50% in the finished cosmetic product does not pose a risk to the health of the consumer, apart from its sensitising potential.0.50%Sensitising potential noted (safe apart from its sensitising potential).

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB
EU Status
prohibited
Max
Annex III/207
Category
Hair Dyes
View full cosmetic safety profile →

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE ChEMBL / DailyMed CHEMBL92636
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
0
View full pharmaceutical profile →

Frequently Asked Questions

What is the GHS hazard classification for 5,6-Dihydroxyindole?

5,6-Dihydroxyindole (CAS 3131-52-0) is classified under EU CLP Annex VI as Acute Tox. 4 *; Eye Dam. 1; Aquatic Chronic 2 with signal word Danger. Hazard statements: H302; H318; H411. Source: EU CLP Annex VI (ECHA).

What is the NOAEL for 5,6-Dihydroxyindole?

5,6-Dihydroxyindole has 34 NOAEL studies in the database. The lowest reported value is 0.012 mg/kg via dermal in rat. Source: SCCS Opinion.

What regulatory lists include 5,6-Dihydroxyindole?

5,6-Dihydroxyindole appears on 1 regulatory/inventory list including Europe; Personal care; restricted. Source: EPA CPDat.

Is 5,6-Dihydroxyindole used in cosmetics?

Yes, 5,6-Dihydroxyindole is also indexed as a cosmetic ingredient under the name DIHYDROXYINDOLE. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for 5,6-Dihydroxyindole come from?

Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.

Does 5,6-Dihydroxyindole have different safety status in cosmetics vs industrial chemicals?

5,6-Dihydroxyindole is prohibited in EU cosmetics at max Annex III/207 but has active industrial GHS classifications (H302, H318, H411).

Is 5,6-Dihydroxyindole used outside industrial chemicals?

5,6-Dihydroxyindole also appears in cosmetics, pharmaceutical databases.