Is DIHYDROXYINDOLE safe in cosmetics?
DIHYDROXYINDOLE has a safety rating of "POOR" in our database. EU status: prohibited. 10 toxicological study endpoint(s) are available in our database.
DIHYDROXYINDOLE
Also known as: UNII-Z3OC8499KG, Dopamine lutine
DIHYDROXYINDOLE (CAS 3131-52-0) is a cosmetic cosmetic ingredient functioning as Hair Dyeing. Reported NOAEL =3 mg/kg bw/day in rat (SCCNFP_vision_codex); EU Regulation 1223/2009 status: prohibited, max Annex III/207. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 3131-52-0 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
DIHYDROXYINDOLE is prohibited in EU cosmetics at max Annex III/207 but has active industrial GHS classifications (H302, H318, H411).
Source: Cosmetics: ingredients.eu_status/eu_max; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Hair Dyeing
Safety Rating
POOR
Chemistry & Identifiers
IUPAC Name
1H-indole-5,6-diol
InChIKey
SGNZYJXNUURYCH-UHFFFAOYSA-N
Regulatory Status
EU EU Status
prohibited
EU Max Conc.
Annex III/207
US US Status
Not specifically regulated
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Toxicological Studies
10 study endpoints found for DIHYDROXYINDOLE. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =3 mg/kg bw/day | dermal | rat | repeated dose toxicity | SCCNFP_vision_codex |
| NOAEL | =3 mg/kg | oral | rat | dermal absorption | SCCNFP_vision_codex |
| NOAEL | =3 mg/kg/day | - | rat | NOAEL study | SCCNFP_vision_codex |
| NOAEL | =3 mg/kg bw/day | dermal | rat | repeated dose toxicity | SCCNFP_vision_codex |
| NOAEL | =3 mg/kg | oral | rat | dermal absorption | SCCNFP_vision_codex |
| NOAEL | =3 mg/kg/day | - | rat | NOAEL study | SCCNFP_vision_codex |
| NOAEL | =3 mg/kg bw/day | dermal | rat | repeated dose toxicity | SCCNFP_vision_codex |
| NOAEL | =3 mg/kg | oral | rat | dermal absorption | SCCNFP_vision_codex |
| NOAEL | =3 mg/kg/day | - | rat | NOAEL study | SCCNFP_vision_codex |
| NOAEL | =3 mg/kg bw/day | dermal | rat | repeated dose toxicity | SCCNFP_vision_codex |
EU CLP Annex VI Harmonized Classification
Legally binding harmonized classification per Regulation (EC) No 1272/2008 (CLP) Annex VI.
Signal Word
Danger
Pictograms
Harmful / IrritantCorrosiveEnvironmental Hazard
Hazard Class and Category
Acute Tox. 4 *; Eye Dam. 1; Aquatic Chronic 2
Hazard Statements
- H302 Harmful if swallowed
- H318 Causes serious eye damage
- H411 Toxic to aquatic life with long lasting effects
Inserted via ATP: CLP00
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
Ceased manufacture
Substance Type
SUBSTANCE
SVHC Candidate
No
Hazard classification: Restricted (Annex XVII)
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
SA Saudi SFDA (III - Restricted)
Product type: (a) Hair dye substance in oxidative hair dye products.
BRIN Brazil/India Cosmetics
India: Restricted
Additional Jurisdictional Restrictions (1)
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| BR | permitted_hair_dye | - | Non-oxidative hair dye (progressive color) |
Expanded Dermal Absorption Data
Cross-database dermal penetration: EPA Dryad physics-based, Roberts Mendeley permeation, and SCCS-aggregated measured values.
Aggregated DA Values (4 records across 5 sources)
| Type | DA % | Method | Skin Model | SCCS Ref |
|---|---|---|---|---|
| measured | 0.41% | - | - | SCCP/0045 |
| measured | 0.3% | - | - | SCCP/0045 |
| measured | 0.053% | - | - | SCCP/0045 |
| measured | 96.4% | - | - | SCCP/0045 |
Additional Ingredient Properties
1 property record from structured ingredient metadata.
hair_dye
{"cas_number": "3131-52-0", "ingredient_class": "oxidative_dye_coupler", "chemical_class": "other", "molecular_weight_Da": "149.15", "color_result_on_hair": "Dark brown/black progressive", "shade_range": "brown", "primary_function": "coupler", "oxidative_dye_type": "coupler", "requires_developer": "no", "permanence": "semi_permanent", "oxidation_mechanism": "coupling", "hair_penetration_depth": "c…
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Dye
Regulatory List Membership (1)
EU CosIng Cosmetics Ingredient Database
Expert Verdict
Expert safety assessment and concern-level summary for DIHYDROXYINDOLE.
Regulatory Flags
cosing-sourced
eu-prohibited
needs-enrichment
eu_cosing_listed
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to DIHYDROXYINDOLE by CAS number or substance name.
Studies
52
Lowest NOAEL
0.012
Highest NOAEL
500
Units vary across source rows: mg/kg bw/day, mg/kg bw/d, mg/kg
SCCS_vision_codex
SCCNFP_vision_codex
Dermal Absorption
View details ->| Absorption % | Method | Vehicle |
|---|---|---|
| 0.41% | - | - |
| 0.3% | - | - |
| 0.053% | - | - |
| 96.4% | - | - |
Known Synonyms
UNII-Z3OC8499KG
Dopamine lutine
Chemical Function
Dye
Regulatory Lists
Europe; Personal care; restricted
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL92636
Frequently Asked Questions
Is DIHYDROXYINDOLE allowed in the EU?
DIHYDROXYINDOLE EU regulatory status: prohibited. Maximum allowed concentration: Annex III/207. This is based on EU Regulation 1223/2009 and its amendments.
What does DIHYDROXYINDOLE do in cosmetics?
DIHYDROXYINDOLE functions as: Hair Dyeing. It is classified as a cosmetic ingredient in our database. CAS number: 3131-52-0.
What is the NOAEL for DIHYDROXYINDOLE?
The NOAEL (No Observed Adverse Effect Level) for DIHYDROXYINDOLE is =3 mg/kg bw/day based on a repeated dose toxicity study via dermal route in rat. A total of 10 study endpoints are available. Source: SCCNFP_vision_codex.
Is DIHYDROXYINDOLE used outside cosmetics?
DIHYDROXYINDOLE also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does DIHYDROXYINDOLE have different safety status in cosmetics vs industrial chemicals?
DIHYDROXYINDOLE is prohibited in EU cosmetics at max Annex III/207 but has active industrial GHS classifications (H302, H318, H411).
Compliance Tools
Check DIHYDROXYINDOLE compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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