NOAEL Data Cosmetic Ingredient

4-(4-Hydroxy-4-methylpentyl)cyclohex-3-ene-1-carbaldehyde

Also known as: 3-Cyclohexene-1-carboxaldehyde, 4-(4-hydroxy-4-methylpentyl)-, BRN 2046455, EINECS 250-863-4, 4-(4-Hydroxy-4-methylpentyl)-3-cyclohexene-1-carboxaldehyde, UNII-QUE43B9Z2Q

CAS 31906-04-4

4-(4-Hydroxy-4-methylpentyl)cyclohex-3-ene-1-carbaldehyde (CAS 31906-04-4) is a chemical substance. Key regulatory status: 7 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, SCCS.

View cosmetic safety profile for HICC (Hydroxyisohexyl 3-Cyclohexene Carboxaldehyde) →

SOURCE noael studies public
NOAEL studies
44
SOURCE chemical inventory jurisdictions
Regulatory lists
7
SOURCE eu clp annex vi
GHS signal
Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 11 fields
Name
4-(4-Hydroxy-4-methylpentyl)cyclohex-3-ene-1-carbaldehyde
CAS Number
31906-04-4
DTXSID
DTXSID1027970
Molecular Formula
C13H22O2
InChI Key
ORMHZBNNECIKOH-UHFFFAOYSA-N
Monoisotopic Mass
210.16198
Synonyms
3-Cyclohexene-1-carboxaldehyde, 4-(4-hydroxy-4-methylpentyl)-BRN 2046455EINECS 250-863-44-(4-Hydroxy-4-methylpentyl)-3-cyclohexene-1-carboxaldehydeUNII-QUE43B9Z2Q

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 60 records
FragranceDeodorizer

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 7 records
ListKeywordSource
IFRA TransparencyIFRAIFRA
consumer_productP&GProctor & Gamble
inert_ingredient; non_food_use; PesticidesEPACPCat
EuropeDanish Environmental Protection AgencyDanish EPA
children; Europe; Personal care - specialized bath products - bath saltsDanish Environmental Protection AgencyDanish EPA
children; Europe; Personal careDanish Environmental Protection AgencyDanish EPA
Cleaning products and household care - air freshener; detected; Europe; Vehicle - car interior - auto air freshenerDanish Environmental Protection AgencyDanish EPA

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 44 of 44 studies
ValueUnitEndpointRouteSpeciesSource
75.2ug/mLCD54, EC200Dermal-NTP_ICE_skin_sensitization
5.8ug/mLCD86, EC150Dermal-NTP_ICE_skin_sensitization
6.2ug/mLCD86, EC150Dermal-NTP_ICE_skin_sensitization
76ug/mLCD86, EC150Dermal-NTP_ICE_skin_sensitization
24.06ug/mLCV70Dermal-NTP_ICE_skin_sensitization
254.8ug/mLCV75Dermal-NTP_ICE_skin_sensitization
255ug/mLCV75Dermal-NTP_ICE_skin_sensitization
9.1%Depletion CysDermal-NTP_ICE_skin_sensitization
39.4%Depletion CysDermal-NTP_ICE_skin_sensitization
3.4%Depletion LysDermal-NTP_ICE_skin_sensitization
6.3%Depletion LysDermal-NTP_ICE_skin_sensitization
7.7%Depletion Lys + CysDermal-NTP_ICE_skin_sensitization
21.4%Depletion Lys + CysDermal-NTP_ICE_skin_sensitization
71.84uMEC1.5Dermal-NTP_ICE_skin_sensitization
79.6uMEC1.5Dermal-NTP_ICE_skin_sensitization
17%EC3DermalMouseNTP_ICE_skin_sensitization
17%EC3DermalMouseNTP_ICE_skin_sensitization
17%EC3DermalMouseNTP_ICE_skin_sensitization
17%EC3DermalMouseNTP_ICE_skin_sensitization
200.3uMEC3Dermal-NTP_ICE_skin_sensitization
QUE43B9Z2QUNIIFDA UNII substance identifier--openFDA substances
QUE43B9Z2QUNIIFDA UNII substance identifier--openFDA substances
QUE43B9Z2QUNIIFDA UNII substance identifier--openFDA substances
QUE43B9Z2QUNIIFDA UNII substance identifier--openFDA substances
355.4uMIC50Dermal-NTP_ICE_skin_sensitization
428.65uMIC50Dermal-NTP_ICE_skin_sensitization
16.1ratioImaxDermal-NTP_ICE_skin_sensitization
20.31ratioImaxDermal-NTP_ICE_skin_sensitization
-%Incidence of positive responsesDermalHumanNTP_ICE_skin_sensitization
775ug/cm2Induction dose per skin areaDermalHumanNTP_ICE_skin_sensitization
3100ug/cm2Induction dose per skin areaDermalHumanNTP_ICE_skin_sensitization
6750ug/cm2Induction dose per skin areaDermalHumanNTP_ICE_skin_sensitization
8264ug/cm2Induction dose per skin areaDermalHumanNTP_ICE_skin_sensitization
=0.02%NOAEL--SCCS_vision_codex
=0.02%NOAEL--SCCS_vision_codex
=0.02%NOAEL--SCCS_vision_codex
=0.02%NOAEL--SCCS_vision_codex
=4000µg/cm2NOAEL--SCCS_vision_codex
=4000µg/cm2NOAEL--SCCS_vision_codex
=4000µg/cm2NOAEL--SCCS_vision_codex
=4000µg/cm2NOAEL--SCCS_vision_codex
3unitlessRelative reliability scoreDermalHumanNTP_ICE_skin_sensitization
0.02%sensitisation--UnifiedCodex:SCCS_SHADOW:beta.noael_studies
4000µg/cm2sensitisation--UnifiedCodex:SCCS_SHADOW:beta.noael_studies

Showing 44 of 44 studies

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records
Inventory Status
listed

SCCS Opinions

EU Scientific Committee opinions tied to the matched substance.

SOURCE EU SCCS 1 opinions
OpinionDateConclusionMax Conc.Concerns
SCCP/0838/047 December 2004Insufficient data for complete assessment; contact allergy is a confirmed problem; up to 0.02% associated with low sensitisation potential but highest safe level not confirmed. Full toxicological data required.Up to 0.02% associated with low sensitisation (from SCCNFP/0743/03); current higher use levels (200 ppm = 0.02%) cause sensitisation induction and elicitationWidespread contact allergy in Europe; current use levels inadequate for protection; requires full toxicological assessment including genotoxicity; later confirmed unsafe even at 200 ppm (SCCS/1459/11) and banned from EU cosmetics in 2017

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB
EU Status
restricted
Max
1.5%
Category
fragrance
View full cosmetic safety profile →

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL LYRAL
ChEMBL Phase
-1
Adverse Events
0
Bioactivity
0
View full pharmaceutical profile →

Frequently Asked Questions

What is the NOAEL for 4-(4-Hydroxy-4-methylpentyl)cyclohex-3-ene-1-carbaldehyde?

4-(4-Hydroxy-4-methylpentyl)cyclohex-3-ene-1-carbaldehyde has 44 NOAEL studies in the database. The lowest reported value is 0 % via Dermal in Human. Source: NTP_ICE_skin_sensitization.

What regulatory lists include 4-(4-Hydroxy-4-methylpentyl)cyclohex-3-ene-1-carbaldehyde?

4-(4-Hydroxy-4-methylpentyl)cyclohex-3-ene-1-carbaldehyde appears on 7 regulatory/inventory lists including IFRA Transparency, consumer_product, inert_ingredient; non_food_use; Pesticides, and 4 more. Source: EPA CPDat.

Is 4-(4-Hydroxy-4-methylpentyl)cyclohex-3-ene-1-carbaldehyde used in cosmetics?

Yes, 4-(4-Hydroxy-4-methylpentyl)cyclohex-3-ene-1-carbaldehyde is also indexed as a cosmetic ingredient under the name HICC (Hydroxyisohexyl 3-Cyclohexene Carboxaldehyde). View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for 4-(4-Hydroxy-4-methylpentyl)cyclohex-3-ene-1-carbaldehyde come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.

Is 4-(4-Hydroxy-4-methylpentyl)cyclohex-3-ene-1-carbaldehyde used outside industrial chemicals?

4-(4-Hydroxy-4-methylpentyl)cyclohex-3-ene-1-carbaldehyde also appears in cosmetics, pharmaceutical databases.