Is HICC (Hydroxyisohexyl 3-Cyclohexene Carboxaldehyde) safe in cosmetics?
HICC (Hydroxyisohexyl 3-Cyclohexene Carboxaldehyde) has a safety rating of "GOOD" in our database. EU status: restricted. US status: permitted.
Good
Fragrance
HICC (Hydroxyisohexyl 3-Cyclohexene Carboxaldehyde)
Also known as: 3-Cyclohexene-1-carboxaldehyde, 4-(4-hydroxy-4-methylpentyl)-, BRN 2046455, EINECS 250-863-4, 4-(4-Hydroxy-4-methylpentyl)-3-cyclohexene-1-carboxaldehyde, UNII-QUE43B9Z2Q
INCI: HICC
HICC (Hydroxyisohexyl 3-Cyclohexene Carboxaldehyde) (CAS 31906-04-4) is a cosmetic fragrance functioning as Fragrance ingredient. EU Regulation 1223/2009 status: restricted, max 1.5%. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in pharmaceutical data.
View industrial chemical safety profile for CAS 31906-04-4 →
Auto-generated CPSR Part A draft with source citations
Function
Fragrance ingredient
Safety Rating
GOOD
Regulatory Status
EU EU Status
restricted
EU Max Conc.
1.5%
US US Status
permitted
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for HICC (Hydroxyisohexyl 3-Cyclohexene Carboxaldehyde).
Calculate MoS for your specific formulation with the MoS Calculator.
HRIPT Human Patch Test Studies
5 human repeat insult patch tests aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HRIPT | 201 | 0 | 4000 | 4000 | non-sensitizer |
| HMT | - | 0 | 6750 | - | - |
| HRIPT | - | 0 | 775 | - | - |
| HRIPT | - | 0 | 3100.01 | - | - |
| HRIPT | - | 0 | 8264 | - | - |
Endocrine Disruptor Evidence (Expanded)
Cross-referenced EDC classifications, mechanism data, and dose-response evidence from EDLists, SIN List, and cosmetic-specific detail sources.
Cosmetic-Specific Mechanism
Category: fragrance
Receptor targets: ERα (limited data)
LOEC: 100 µM
EU status: banned (allergen; Annex II)
weak modulator
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
ASEAN Cosmetic Directive (II)
Ref: 1380
BRIN Brazil/India Cosmetics
Brazil: Restricted (Fragrance Allergen) · max >0.001% leave-on / >0.01% rinse-off requires labeling
Additional Jurisdictional Restrictions (2)
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| GCC | banned | - | All cosmetics |
| KR | prohibited | - | - |
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Deodorizer
Fragrance
Regulatory List Membership (3)
EU Restricted for Children (Cosmetics)
IFRA Fragrance Transparency List
Consumer Product Chemical
Expert Verdict
Expert safety assessment and concern-level summary for HICC (Hydroxyisohexyl 3-Cyclohexene Carboxaldehyde).
Regulatory Flags
EU Restricted
eu_children_restricted
ifra_fragrance
Known Synonyms
3-Cyclohexene-1-carboxaldehyde, 4-(4-hydroxy-4-methylpentyl)-
BRN 2046455
EINECS 250-863-4
4-(4-Hydroxy-4-methylpentyl)-3-cyclohexene-1-carboxaldehyde
UNII-QUE43B9Z2Q
Chemical Function
Fragrance
Regulatory Lists
IFRA Transparency
consumer_product
inert_ingredient; non_food_use; Pesticides
Europe
children; Europe; Personal care - specialized bath products - bath salts
children; Europe; Personal care
Cleaning products and household care - air freshener; detected; Europe; Vehicle - car interior - auto air freshener
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
LYRAL
ChEMBL ID
CHEMBL3182066
Max Phase
-1
Frequently Asked Questions
Is HICC (Hydroxyisohexyl 3-Cyclohexene Carboxaldehyde) allowed in the EU?
HICC (Hydroxyisohexyl 3-Cyclohexene Carboxaldehyde) EU regulatory status: restricted. Maximum allowed concentration: 1.5%. This is based on EU Regulation 1223/2009 and its amendments.
What does HICC (Hydroxyisohexyl 3-Cyclohexene Carboxaldehyde) do in cosmetics?
HICC (Hydroxyisohexyl 3-Cyclohexene Carboxaldehyde) functions as: Fragrance ingredient. It is classified as a Fragrance in our database. CAS number: 31906-04-4.
Is HICC (Hydroxyisohexyl 3-Cyclohexene Carboxaldehyde) used outside cosmetics?
HICC (Hydroxyisohexyl 3-Cyclohexene Carboxaldehyde) also appears in pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check HICC (Hydroxyisohexyl 3-Cyclohexene Carboxaldehyde) compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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Antioxidant
Hydroxyisohexyl 3-Cyclohexene Carboxaldehyde
Poor
Chemical family
Fragrance ingredient
Vinyl Cyclohexene Carboxaldehyde (HICC/Lyral®)
Poor
Chemical family
Fragrance ingredient
HICC (Hydroxyisohexyl 3-Cyclohexene Carboxaldehyde) - BANNED
Good
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Fragrance ingredient
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