What is the NOAEL for 2-Oxobutanedioic acid?
2-Oxobutanedioic acid has 4 NOAEL studies in the database. The lowest reported value is 2F399MM81J UNII. Source: openFDA substances.
NOAEL Data
REACH Registered
Cosmetic Ingredient
2-Oxobutanedioic acid
Also known as: EC No.: 206-329-8, EINECS 206-329-8, Oxalacetic acetic, UNII-2F399MM81J, 2-Ketosuccinate (+13 more)
CAS 328-42-7
2-Oxobutanedioic acid (CAS 328-42-7) is a chemical substance. Key regulatory status: REACH registered, cosmetic ingredient cross-reference; source data from EPA ToxValDB, AICIS, ECHA REACH.
Cross-Vertical Regulatory Divergence
2-Oxobutanedioic acid is classified GHS Danger (H314, H319) in the chemicals database but is allowed in EU cosmetics.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
4
SOURCE
chemical inventory jurisdictions
Regulatory lists
0
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
24 fields
Name
2-Oxobutanedioic acid
CAS Number
328-42-7
DTXSID
DTXSID8021646
Molecular Formula
C4H4O5
InChI Key
KHPXUQMNIQBQEV-UHFFFAOYSA-N
Monoisotopic Mass
132.005873
Synonyms
EC No.: 206-329-8EINECS 206-329-8Oxalacetic aceticUNII-2F399MM81J2-Ketosuccinate2-Oxobutanedioate2-Oxosuccinate3-carboxy-3-oxopropanoic acidKetosuccinateOAAOxaloacetateOxaloethanoate
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 4 of 4 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 2F399MM81J | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 2F399MM81J | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 2F399MM81J | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 2F399MM81J | UNII | FDA UNII substance identifier | - | - | openFDA substances |
Showing 4 of 4 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Oxalacetic acid | 206-329-8 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Other
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
OXALOACETATE
ChEMBL Phase
2
Adverse Events
0
Bioactivity
1
Frequently Asked Questions
Is 2-Oxobutanedioic acid used in cosmetics?
Yes, 2-Oxobutanedioic acid is also indexed as a cosmetic ingredient under the name OXOSUCCINIC ACID. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 2-Oxobutanedioic acid come from?
Safety data is sourced from EPA ToxValDB, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Does 2-Oxobutanedioic acid have different safety status in cosmetics vs industrial chemicals?
2-Oxobutanedioic acid is classified GHS Danger (H314, H319) in the chemicals database but is allowed in EU cosmetics.
Is 2-Oxobutanedioic acid used outside industrial chemicals?
2-Oxobutanedioic acid also appears in cosmetics, pharmaceutical databases.