Is OXOSUCCINIC ACID safe in cosmetics?
OXOSUCCINIC ACID has a safety rating of "GOOD" in our database. EU status: permitted. US status: allowed.
Good
Cosmetic Ingredient
OXOSUCCINIC ACID
Also known as: EC No.: 206-329-8, EINECS 206-329-8, Oxalacetic acetic, UNII-2F399MM81J, 2-Ketosuccinate (+13 more)
OXOSUCCINIC ACID (CAS 328-42-7) is a cosmetic cosmetic ingredient functioning as Skin conditioning — also known as oxaloacetic acid, a key Krebs cycle. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 328-42-7 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
OXOSUCCINIC ACID is classified GHS Danger (H314, H319) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Skin conditioning — also known as oxaloacetic acid, a key Krebs cycle intermediate
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
2-oxobutanedioic acid
InChIKey
KHPXUQMNIQBQEV-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
allowed
US Notes
Allowed — no specific restriction
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1 - 10 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Expert Verdict
Expert safety assessment and concern-level summary for OXOSUCCINIC ACID.
Regulatory Flags
cosing-sourced
eu-permitted
needs-enrichment
Known Synonyms
EC No.: 206-329-8
EINECS 206-329-8
Oxalacetic acetic
UNII-2F399MM81J
2-Ketosuccinate
2-Oxobutanedioate
2-Oxosuccinate
3-carboxy-3-oxopropanoic acid
Ketosuccinate
OAA
Oxaloacetate
Oxaloethanoate
Oxaloethanoic acid
Oxosuccinate
a-Ketosuccinate
a-Ketosuccinic acid
alpha-Ketosuccinate
alpha-Ketosuccinic acid
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
OXALOACETATE
ChEMBL ID
CHEMBL1794791
Max Phase
2
Frequently Asked Questions
Is OXOSUCCINIC ACID allowed in the EU?
OXOSUCCINIC ACID EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does OXOSUCCINIC ACID do in cosmetics?
OXOSUCCINIC ACID functions as: Skin conditioning — also known as oxaloacetic acid, a key Krebs cycle intermediate. It is classified as a cosmetic ingredient in our database. CAS number: 328-42-7.
Is OXOSUCCINIC ACID used outside cosmetics?
OXOSUCCINIC ACID also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does OXOSUCCINIC ACID have different safety status in cosmetics vs industrial chemicals?
OXOSUCCINIC ACID is classified GHS Danger (H314, H319) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
Check OXOSUCCINIC ACID compliance across multiple jurisdictions:
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Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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