NOAEL Data REACH Registered Cosmetic Ingredient

2-Methoxymethyl-p-phenylenediamine

Also known as: UNII-5982W4U40M, 1,4-Benzenediamine, 2-(methoxymethyl)-, 1,4-Diamino-2-(methoxymethyl)benzene

CAS 337906-36-2

2-Methoxymethyl-p-phenylenediamine (CAS 337906-36-2) is a chemical substance. Key regulatory status: REACH registered, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, SCCS, ECHA REACH.

View cosmetic safety profile for 2-Methoxymethyl-P-Phenylenediamine (ME-PPD) →

SOURCE noael studies public
NOAEL studies
5
SOURCE chemical inventory jurisdictions
Regulatory lists
0
SOURCE eu clp annex vi
GHS signal
Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 9 fields
Name
2-Methoxymethyl-p-phenylenediamine
CAS Number
337906-36-2
DTXSID
DTXSID50187451
Molecular Formula
C8H12N2O
InChI Key
AVKBLCWBDLLVRL-UHFFFAOYSA-N
Monoisotopic Mass
152.094963
Synonyms
UNII-5982W4U40M1,4-Benzenediamine, 2-(methoxymethyl)-1,4-Diamino-2-(methoxymethyl)benzene

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 2 records
Dye

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 5 of 5 studies
ValueUnitEndpointRouteSpeciesSource
=1.08mg/m3DNEL systemicinhalationHumanToxValDB_GESTIS_DNEL
5982W4U40MUNIIFDA UNII substance identifier--openFDA substances
5982W4U40MUNIIFDA UNII substance identifier--openFDA substances
5982W4U40MUNIIFDA UNII substance identifier--openFDA substances
5982W4U40MUNIIFDA UNII substance identifier--openFDA substances

Showing 5 of 5 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records
StatusNameEC NumberLink
Registered2-(methoxymethyl)benzene-1,4-diamine679-526-3ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records
Inventory Status
listed_with_terms
Conditions
Specific information requirements: Obligations to provide information apply. These obligations are: 1. A person introducing this chemical must tell us in writing within 28 calendar days if any of the following circumstances have occurred in relation to their introduction (importation or manufacture): a. the concentration of the notified chemical in imported oxidative hair dye products exceeds or is intended to exceed 3.6%; b. the on head concentration of the notified chemical exceeds or is intended to exceed 1.8%. 2. A person who introduces this chemical must tell us in writing within 28 calendar days if they become aware of any of the following circumstances, namely, that since the assessment under the Industrial Chemicals (Notification and Assessment) Act 1989: a. the function or use of the chemical has changed, or is likely to change, significantly; b. the amount of the chemical being introduced has increased, or is likely to increase, significantly; c. in the case of a chemical not manufactured, or proposed to be manufactured, in Australia at the time of the assessment—it has begun to be manufactured in Australia; d. the method of manufacture of the chemical in Australia has changed, or is likely to change, in a way that may result in an increased risk of an adverse effect of the chemical on occupational health and safety, public health or the environment; e. additional information has become available to the person as to an adverse effect of the chemical on occupational health and safety, public health or the environment.

SCCS Opinions

EU Scientific Committee opinions tied to the matched substance.

SOURCE EU SCCS 2 opinions
OpinionDateConclusionMax Conc.Concerns
SCCS/1603/1812 March 2019safe1.8%sensitization; professional use only
SCCS/1491/1226 February 2013safe1.8%moderate sensitiser

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB
EU Status
prohibited
Max
1.8%
Category
Colorant
View full cosmetic safety profile →

Frequently Asked Questions

What is the NOAEL for 2-Methoxymethyl-p-phenylenediamine?

2-Methoxymethyl-p-phenylenediamine has 5 NOAEL studies in the database. The lowest reported value is 1.08 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.

Is 2-Methoxymethyl-p-phenylenediamine used in cosmetics?

Yes, 2-Methoxymethyl-p-phenylenediamine is also indexed as a cosmetic ingredient under the name 2-Methoxymethyl-P-Phenylenediamine (ME-PPD). View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for 2-Methoxymethyl-p-phenylenediamine come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB. All data traces to primary regulatory sources and is updated from official government databases.

Does 2-Methoxymethyl-p-phenylenediamine have different safety status in cosmetics vs industrial chemicals?

2-Methoxymethyl-p-phenylenediamine is prohibited in EU cosmetics at max 1.8% but has active industrial GHS classifications (H301, H311, H331, H317, H319, H332, H411).

Is 2-Methoxymethyl-p-phenylenediamine used outside industrial chemicals?

2-Methoxymethyl-p-phenylenediamine also appears in cosmetics databases.