What is the NOAEL for 2-Methoxymethyl-p-phenylenediamine?
2-Methoxymethyl-p-phenylenediamine has 5 NOAEL studies in the database. The lowest reported value is 1.08 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
Also known as: UNII-5982W4U40M, 1,4-Benzenediamine, 2-(methoxymethyl)-, 1,4-Diamino-2-(methoxymethyl)benzene
CAS 337906-36-2
2-Methoxymethyl-p-phenylenediamine (CAS 337906-36-2) is a chemical substance. Key regulatory status: REACH registered, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, SCCS, ECHA REACH.
View cosmetic safety profile for 2-Methoxymethyl-P-Phenylenediamine (ME-PPD) →
2-Methoxymethyl-p-phenylenediamine is prohibited in EU cosmetics at max 1.8% but has active industrial GHS classifications (H301, H311, H331, H317, H319, H332, H411).
CAS, identifiers, formula, and alternate names for the matched substance record.
Industrial and product-use categories associated with this substance.
Toxicology endpoints rendered from public NOAEL study rows.
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =1.08 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| 5982W4U40M | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 5982W4U40M | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 5982W4U40M | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 5982W4U40M | UNII | FDA UNII substance identifier | - | - | openFDA substances |
Showing 5 of 5 studies
Registration status from the ECHA REACH registered substances database.
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 2-(methoxymethyl)benzene-1,4-diamine | 679-526-3 | ECHA overview → |
Australian industrial chemicals inventory status and applicable conditions.
EU Scientific Committee opinions tied to the matched substance.
| Opinion | Date | Conclusion | Max Conc. | Concerns |
|---|---|---|---|---|
| SCCS/1603/18 | 12 March 2019 | safe | 1.8% | sensitization; professional use only |
| SCCS/1491/12 | 26 February 2013 | safe | 1.8% | moderate sensitiser |
Same-CAS cosmetic ingredient record for cross-vertical context.
2-Methoxymethyl-p-phenylenediamine has 5 NOAEL studies in the database. The lowest reported value is 1.08 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
Yes, 2-Methoxymethyl-p-phenylenediamine is also indexed as a cosmetic ingredient under the name 2-Methoxymethyl-P-Phenylenediamine (ME-PPD). View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB. All data traces to primary regulatory sources and is updated from official government databases.
2-Methoxymethyl-p-phenylenediamine is prohibited in EU cosmetics at max 1.8% but has active industrial GHS classifications (H301, H311, H331, H317, H319, H332, H411).
2-Methoxymethyl-p-phenylenediamine also appears in cosmetics databases.