Is 2-Methoxymethyl-P-Phenylenediamine (ME-PPD) safe in cosmetics?
2-Methoxymethyl-P-Phenylenediamine (ME-PPD) has a safety rating of "GOOD" in our database. EU status: prohibited. US status: permitted.
Good
Cosmetic Ingredient
2-Methoxymethyl-P-Phenylenediamine (ME-PPD)
Also known as: UNII-5982W4U40M, 1,4-Benzenediamine, 2-(methoxymethyl)-, 1,4-Diamino-2-(methoxymethyl)benzene
INCI: 2-METHOXYMETHYL-P-PHENYLENEDIAMINE
2-Methoxymethyl-P-Phenylenediamine (ME-PPD) (CAS 337906-36-2) is a cosmetic cosmetic ingredient functioning as Hair dyeing. EU Regulation 1223/2009 status: prohibited, max 1.8%. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 337906-36-2 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
2-Methoxymethyl-P-Phenylenediamine (ME-PPD) is prohibited in EU cosmetics at max 1.8% but has active industrial GHS classifications (H301, H311, H331, H317, H319, H332, H411).
Source: Cosmetics: ingredients.eu_status/eu_max; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Hair dyeing
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
2-(methoxymethyl)benzene-1,4-diamine
InChIKey
AVKBLCWBDLLVRL-UHFFFAOYSA-N
Regulatory Status
EU EU Status
prohibited
EU Max Conc.
1.8%
US US Status
permitted
US Notes
Not specifically restricted by FDA; hair dyes enjoy a special exemption from color additive provisions under FD&C Act §601, requiring a patch-test warning
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for 2-Methoxymethyl-P-Phenylenediamine (ME-PPD).
Calculate MoS for your specific formulation with the MoS Calculator.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10 - 100 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Dye
Expert Verdict
Expert safety assessment and concern-level summary for 2-Methoxymethyl-P-Phenylenediamine (ME-PPD).
Regulatory Flags
potential-allergen
Known Synonyms
UNII-5982W4U40M
1,4-Benzenediamine, 2-(methoxymethyl)-
1,4-Diamino-2-(methoxymethyl)benzene
Chemical Function
Dye
Australian Status
AICIS status: listed_with_terms
Specific information requirements: Obligations to provide information apply. These obligations are: 1. A person introducing this chemical must tell us in writing within 28 calendar days if any of the following circumstances have occurred in relation to their introduction (importation or manufacture): a. the concentration of the notified chemical in imported...
Frequently Asked Questions
Is 2-Methoxymethyl-P-Phenylenediamine (ME-PPD) allowed in the EU?
2-Methoxymethyl-P-Phenylenediamine (ME-PPD) EU regulatory status: prohibited. Maximum allowed concentration: 1.8%. This is based on EU Regulation 1223/2009 and its amendments.
What does 2-Methoxymethyl-P-Phenylenediamine (ME-PPD) do in cosmetics?
2-Methoxymethyl-P-Phenylenediamine (ME-PPD) functions as: Hair dyeing. It is classified as a cosmetic ingredient in our database. CAS number: 337906-36-2.
Is 2-Methoxymethyl-P-Phenylenediamine (ME-PPD) used outside cosmetics?
2-Methoxymethyl-P-Phenylenediamine (ME-PPD) also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does 2-Methoxymethyl-P-Phenylenediamine (ME-PPD) have different safety status in cosmetics vs industrial chemicals?
2-Methoxymethyl-P-Phenylenediamine (ME-PPD) is prohibited in EU cosmetics at max 1.8% but has active industrial GHS classifications (H301, H311, H331, H317, H319, H332, H411).
Compliance Tools
Check 2-Methoxymethyl-P-Phenylenediamine (ME-PPD) compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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