Good Cosmetic Ingredient

2-Methoxymethyl-P-Phenylenediamine (ME-PPD)

INCI: 2-METHOXYMETHYL-P-PHENYLENEDIAMINE

CAS Number
337906-36-2
Function
Hair dyeing
Safety Rating
GOOD

Regulatory Status

🇪🇺 EU Status prohibited
EU Max Conc. 1.8%
🇺🇸 US Status permitted
US Notes Not specifically restricted by FDA; hair dyes enjoy a special exemption from color additive provisions under FD&C Act §601, requiring a patch-test warning

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Phenylenediamine derivative with potential cross-reactivity with PPD in highly sensitized individuals; standard hair dye warnings required on label.

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Concern Level: Moderate

Regulatory Flags

potential-allergen

Frequently Asked Questions

Is 2-Methoxymethyl-P-Phenylenediamine (ME-PPD) safe in cosmetics?

Phenylenediamine derivative with potential cross-reactivity with PPD in highly sensitized individuals; standard hair dye warnings required on label. The EU classifies 2-Methoxymethyl-P-Phenylenediamine (ME-PPD) as "prohibited". Safety rating: GOOD.

Is 2-Methoxymethyl-P-Phenylenediamine (ME-PPD) allowed in the EU?

2-Methoxymethyl-P-Phenylenediamine (ME-PPD) EU regulatory status: prohibited. Maximum allowed concentration: 1.8%. This is based on EU Regulation 1223/2009 and its amendments.

What does 2-Methoxymethyl-P-Phenylenediamine (ME-PPD) do in cosmetics?

2-Methoxymethyl-P-Phenylenediamine (ME-PPD) functions as: Hair dyeing. It is classified as a cosmetic ingredient in our database. CAS number: 337906-36-2.

What is the Margin of Safety for 2-Methoxymethyl-P-Phenylenediamine (ME-PPD)?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

Compliance Tools

Check 2-Methoxymethyl-P-Phenylenediamine (ME-PPD) compliance across multiple jurisdictions:

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Ingredient Decoder
Paste a full ingredient list for instant analysis
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82 Allergen Checker
Check for EU declarable fragrance allergens
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Substance Compliance
Check compliance across 55 jurisdictions
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
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Heavy Metal Limits
Compare limits across jurisdictions

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