What is the NOAEL for 3,5,5-Trimethyl-1-hexanol?
3,5,5-Trimethyl-1-hexanol has 15 NOAEL studies in the database. The lowest reported value is O5KUD6I57K UNII. Source: openFDA substances.
NOAEL Data
REACH Registered
Cosmetic Ingredient
3,5,5-Trimethyl-1-hexanol
Also known as: Caswell No. 892A, EINECS 222-376-7, EPA Pesticide Chemical Code 492200, FEMA No. 3324, Nonylol (+7 more)
CAS 3452-97-9
3,5,5-Trimethyl-1-hexanol (CAS 3452-97-9) is a chemical substance. Key regulatory status: REACH registered, 6 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, ILO ICSC.
Cross-Vertical Regulatory Divergence
3,5,5-Trimethyl-1-hexanol is classified GHS CMR hazard (H315, H319, H373, H412, H227, H302, H313, H361) in the chemicals database but is allowed in EU cosmetics.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
15
SOURCE
chemical inventory jurisdictions
Regulatory lists
6
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
18 fields
Name
3,5,5-Trimethyl-1-hexanol
CAS Number
3452-97-9
DTXSID
DTXSID7029661
Molecular Formula
C9H20O
InChI Key
BODRLKRKPXBDBN-UHFFFAOYSA-N
Monoisotopic Mass
144.151415
Synonyms
Caswell No. 892AEINECS 222-376-7EPA Pesticide Chemical Code 492200FEMA No. 3324NonylolNSC 83151NSC 972263,5,5-TrimethylhexanolTrimethylhexyl alcohol3,5,5-Trimethylhexyl alcoholi-Nonyl alcoholUNII-O5KUD6I57K
ICSC Chemical Safety
International Chemical Safety Card hazard and exposure summary.
SOURCE
ILO/WHO International Chemical Safety Cards
1 records
| Field | Value |
|---|---|
| Short-term Effects | The substance is irritating to the eyes and skin. The vapour is irritating to the eyes, skin and respiratory tract. |
| Long-term Effects | The substance may have effects on the liver and kidneys. |
| Routes of Exposure | The substance can be absorbed into the body by inhalation of its vapour and by ingestion. |
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
5 records
SolventDeodorizerFlavouring and nutrientFragrance
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
6 records
| List | Keyword | Source |
|---|---|---|
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| artificial_saliva; detected; emissions; Europe; Other direct contact consumer goods | Danish Environmental Protection Agency | Danish EPA |
| IFRA Transparency | IFRA | IFRA |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| Europe | European Commission | Fl@vis |
| artificial_saliva; detected; emissions; Europe; Other direct contact consumer goods | Danish Environmental Protection Agency | Danish EPA |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 15 of 15 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| O5KUD6I57K | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| O5KUD6I57K | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| O5KUD6I57K | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| O5KUD6I57K | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| - | % | Incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 5400 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| >2000 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =60 | mg/kg bw/day | LOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| - | unitless | Model Score | - | - | NTP_ICE_endocrine |
| =12 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =60 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| 144 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| =300 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| <1800 | mg/kg bw/day | NOAEL | dermal | Rabbit | ToxValDB_ECHA_IUCLID |
| 3 | unitless | Relative reliability score | Dermal | Human | NTP_ICE_skin_sensitization |
Showing 15 of 15 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 3,5,5-trimethylhexan-1-ol | 222-376-7 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
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CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Fragrance
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CHEMBL3187919
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
0
Frequently Asked Questions
What regulatory lists include 3,5,5-Trimethyl-1-hexanol?
3,5,5-Trimethyl-1-hexanol appears on 5 regulatory/inventory lists including inert_ingredient; non_food_use; Pesticides, artificial_saliva; detected; emissions; Europe; Other direct contact consumer goods, IFRA Transparency, and 2 more. Source: EPA CPDat.
Is 3,5,5-Trimethyl-1-hexanol used in cosmetics?
Yes, 3,5,5-Trimethyl-1-hexanol is also indexed as a cosmetic ingredient under the name Trimethylhexanol. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 3,5,5-Trimethyl-1-hexanol come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ILO/WHO ICSC, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Does 3,5,5-Trimethyl-1-hexanol have different safety status in cosmetics vs industrial chemicals?
3,5,5-Trimethyl-1-hexanol is classified GHS CMR hazard (H315, H319, H373, H412, H227, H302, H313, H361) in the chemicals database but is allowed in EU cosmetics.
Is 3,5,5-Trimethyl-1-hexanol used outside industrial chemicals?
3,5,5-Trimethyl-1-hexanol also appears in cosmetics, pharmaceutical databases.