Is Trimethylhexanol safe in cosmetics?
Trimethylhexanol has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted. 3 toxicological study endpoint(s) are available in our database.
Trimethylhexanol
Also known as: Caswell No. 892A, EINECS 222-376-7, EPA Pesticide Chemical Code 492200, FEMA No. 3324, Nonylol (+7 more)
INCI: TRIMETHYLHEXANOL
Trimethylhexanol (CAS 3452-97-9) is a cosmetic cosmetic ingredient functioning as Perfuming / solvent. NOAEL 12 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
Cross-Vertical Regulatory Divergence
Trimethylhexanol is classified GHS CMR hazard (H315, H319, H373, H412, H227, H302, H313, H361) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu status; Chemicals: ghs classifications.signal word/hazard statement code
Function
Perfuming / solvent
Editorial assessment
GOOD
Preliminary editorial note — not a computed safety verdict.
Chemistry & Identifiers
IUPAC Name
3,5,5-trimethylhexan-1-ol
InChIKey
BODRLKRKPXBDBN-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted for cosmetic use
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Trimethylhexanol.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
3 study endpoints found for Trimethylhexanol. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =12 mg/kg bw/day | oral | Rat | subchronic | ECHA |
| NOAEL | =60 mg/kg bw/day | oral | Rat | reproduction developmental | ECHA |
| NOAEL | =300 mg/kg bw/day | oral | Rat | reproduction developmental | ECHA |
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Short-term Exposure Effects
The substance is irritating to the eyes and skin. The vapour is irritating to the eyes, skin and respiratory tract.
Long-term Exposure Effects
The substance may have effects on the liver and kidneys.
Routes of Exposure
The substance can be absorbed into the body by inhalation of its vapour and by ingestion.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Trimethylhexanol across SCCS product categories, with measured dermal absorption where available.
HRIPT Human Patch Test Studies
1 human repeat insult patch test aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HMT | - | 0 | 5400 | - | - |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1 - 10 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (1)
ICSC Safety Card
0608
Source: WHO/JECFA
Regulatory (2)
JECFA Number
268
Source: WHO/JECFA
JECFA Evaluation
3,5,5-TRIMETHYL-1-HEXANOL | 1997 | No safety concern at current levels of intake when used as a flavouring agent | TRS 884-JECFA 49/37 | FAS 40-JECFA 49/189
Source: WHO/JECFA
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Deodorizer
Flavouring and nutrient
Fragrance
Solvent
Regulatory List Membership (2)
IFRA Fragrance Transparency List
FDA Substances Added to Food (EAFUS)
Editorial summary
Preliminary editorial summary for Trimethylhexanol — not a computed safety verdict. See the sourced toxicological data above.
Regulatory Flags
fragrance-component
ifra_fragrance
fda_food_additive
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Trimethylhexanol by CAS number or substance name.
Studies
3
Lowest NOAEL
12 mg/kg bw/day
Highest NOAEL
300 mg/kg bw/day
ECHA
Known Synonyms
Caswell No. 892A
EINECS 222-376-7
EPA Pesticide Chemical Code 492200
FEMA No. 3324
Nonylol
NSC 83151
NSC 97226
3,5,5-Trimethylhexanol
Trimethylhexyl alcohol
3,5,5-Trimethylhexyl alcohol
i-Nonyl alcohol
UNII-O5KUD6I57K
Chemical Function
Solvent
Deodorizer
Flavouring and nutrient
Fragrance
Regulatory Lists
inert_ingredient; non_food_use; Pesticides
artificial_saliva; detected; emissions; Europe; Other direct contact consumer goods
IFRA Transparency
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
Europe
artificial_saliva; detected; emissions; Europe; Other direct contact consumer goods
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL3187919
Frequently Asked Questions
Is Trimethylhexanol allowed in the EU?
Trimethylhexanol EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Trimethylhexanol do in cosmetics?
Trimethylhexanol functions as: Perfuming / solvent. It is classified as a cosmetic ingredient in our database. CAS number: 3452-97-9.
What is the NOAEL for Trimethylhexanol?
The NOAEL (No Observed Adverse Effect Level) for Trimethylhexanol is =12 mg/kg bw/day based on a subchronic study via oral route in Rat. A total of 3 study endpoints are available. Source: ECHA.
Is Trimethylhexanol used outside cosmetics?
Trimethylhexanol also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Trimethylhexanol have different safety status in cosmetics vs industrial chemicals?
Trimethylhexanol is classified GHS CMR hazard (H315, H319, H373, H412, H227, H302, H313, H361) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
Check Trimethylhexanol compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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