What is the NOAEL for D-Mannose?
D-Mannose has 4 NOAEL studies in the database. The lowest reported value is PHA4727WTP UNII. Source: openFDA substances.
NOAEL Data
REACH Registered
Cosmetic Ingredient
D-Mannose
Also known as: D-(+)-Mannose, EINECS 222-392-4, UNII-PHA4727WTP, D-Mannopyranose
CAS 3458-28-4
D-Mannose (CAS 3458-28-4) is a chemical substance. Key regulatory status: REACH registered, 1 regulatory/inventory list, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
SOURCE
noael studies public
NOAEL studies
4
SOURCE
chemical inventory jurisdictions
Regulatory lists
1
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
10 fields
Name
D-Mannose
CAS Number
3458-28-4
DTXSID
DTXSID5040463
Molecular Formula
C6H12O6
InChI Key
WQZGKKKJIJFFOK-QTVWNMPRSA-N
Monoisotopic Mass
180.063388
Synonyms
D-(+)-MannoseEINECS 222-392-4UNII-PHA4727WTPD-Mannopyranose
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
3 records
Humectant
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
1 records
| List | Keyword | Source |
|---|---|---|
| Canada; pharmaceutical | DrugBank | DrugBank |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 4 of 4 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| PHA4727WTP | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| PHA4727WTP | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| PHA4727WTP | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| PHA4727WTP | UNII | FDA UNII substance identifier | - | - | openFDA substances |
Showing 4 of 4 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | D-mannose | 222-392-4 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Other
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
DEMANNOSE
ChEMBL Phase
2
Adverse Events
471
Bioactivity
0
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
1 food-safety record found.
View full food safety profile →Frequently Asked Questions
What regulatory lists include D-Mannose?
D-Mannose appears on 1 regulatory/inventory list including Canada; pharmaceutical. Source: EPA CPDat.
Is D-Mannose used in cosmetics?
Yes, D-Mannose is also indexed as a cosmetic ingredient under the name Mannose. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for D-Mannose come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS. All data traces to primary regulatory sources and is updated from official government databases.
Is D-Mannose used outside industrial chemicals?
D-Mannose also appears in cosmetics, pharmaceutical, food safety databases.