Is Mannose safe in cosmetics?
Mannose has a safety rating of "EXCELLENT" in our database. EU status: permitted. US status: permitted.
Excellent
Cosmetic Ingredient
Mannose
Also known as: D-(+)-Mannose, EINECS 222-392-4, UNII-PHA4727WTP, D-Mannopyranose
INCI: MANNOSE
Mannose (CAS 3458-28-4) is a cosmetic cosmetic ingredient functioning as Humectant, Skin Conditioning, Anti-Inflammatory. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety, pharmaceutical, and food safety data.
View industrial chemical safety profile for CAS 3458-28-4 →
Auto-generated CPSR Part A draft with source citations
Function
Humectant, Skin Conditioning, Anti-Inflammatory
Safety Rating
EXCELLENT
Chemistry & Identifiers
IUPAC Name
(2S,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanal
InChIKey
GZCGUPFRVQAUEE-KVTDHHQDSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
CIR Expert Panel concluded safe as used in cosmetics. Not GRAS. Reported in VCRP.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Mannose.
Calculate MoS for your specific formulation with the MoS Calculator.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10 - 100 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Additional Ingredient Properties
2 property records from structured ingredient metadata.
acne
{"cas_number": "3458-28-4", "anti_acne_mechanism": "anti_inflammatory", "comedogenicity_rating_0_to_5": "0", "acne_type_efficacy": "inflammatory", "sebum_reduction_pct_clinical": "0-5", "prescription_required_usa": "No", "otc_drug_monograph_category": "No", "max_otc_concentration_pct": "No limit", "japan_quasi_drug_anti_acne": "No", "korea_functional_cosmetic_acne": "No", "eu_cosmetic_restriction_…
anti_aging
{"anti_aging_claim": "hydration-plumping", "mechanism_of_action": "Humectant, water binding, barrier support", "target_skin_layer": "stratum corneum, epidermis", "collagen_stimulation": "No", "elastin_protection": "No", "wrinkle_reduction_pct": "5-10", "clinical_study_duration_weeks": "8", "sample_size": "30", "double_blind": "No", "placebo_controlled": "Yes", "published_journal": "JDD, Int J Cosm…
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Humectant
Expert Verdict
Expert safety assessment and concern-level summary for Mannose.
Known Synonyms
D-(+)-Mannose
EINECS 222-392-4
UNII-PHA4727WTP
D-Mannopyranose
Chemical Function
Humectant
Regulatory Lists
Canada; pharmaceutical
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical and food safety data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
DEMANNOSE
ChEMBL ID
CHEMBL1232295
Max Phase
2
Adverse Event Associations
471
SOURCE
EFSA / FDA GRAS
food_additives
Food Safety Data
Same-CAS food additive or FDA GRAS records from the core public database.
Food Name
D-Mannose (as mild sweetener)
Food Category
sweetener
Frequently Asked Questions
Is Mannose allowed in the EU?
Mannose EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Mannose do in cosmetics?
Mannose functions as: Humectant, Skin Conditioning, Anti-Inflammatory. It is classified as a cosmetic ingredient in our database. CAS number: 3458-28-4.
Is Mannose used outside cosmetics?
Mannose also appears in industrial chemical safety, pharmaceutical, and food safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Mannose compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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Insufficient data
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