What is the NOAEL for Dithiothreitol?
Dithiothreitol has 4 NOAEL studies in the database. The lowest reported value is T8ID5YZU6Y UNII. Source: openFDA substances.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Dithiothreitol
Also known as: DTT (threitol derivative), rel-(2R,3R)-1,4-Dimercapto-2,3-butanedio, DTT, 3-01-00-02360, BRN 1719757 (+10 more)
CAS 3483-12-3
Dithiothreitol (CAS 3483-12-3) is a chemical substance. Key regulatory status: REACH registered, 2 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
Cross-Vertical Regulatory Divergence
Dithiothreitol is prohibited in EU cosmetics but has active industrial GHS classifications (H302, H315, H318, H319, H335, H412, H312).
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
4
SOURCE
chemical inventory jurisdictions
Regulatory lists
2
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
21 fields
Name
Dithiothreitol
CAS Number
3483-12-3
DTXSID
DTXSID5041017
Molecular Formula
C4H10O2S2
InChI Key
VHJLVAABSRFDPM-QWWZWVQMSA-N
Monoisotopic Mass
154.012222
Synonyms
DTT (threitol derivative)rel-(2R,3R)-1,4-Dimercapto-2,3-butanedioDTT3-01-00-02360BRN 17197572,3-Butanediol, 1,4-dimercapto-, DL-threo-Cleland reagent(R*,R*)-(+/-)-1,4-Dimercapto-2,3-butanediolD-1,4-DithiothreitolDithiotreitolEINECS 222-468-7EINECS 248-531-9
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
2 records
Reducing agentHair waving or straightening
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
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EPA CPDat
2 records
| List | Keyword | Source |
|---|---|---|
| Canada; consumer_product; Substances in Products - Canada (4/2014) | Government of Canada | CPCat |
| pharmaceutical | US International Trade Commission | CPCat |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 4 of 4 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| T8ID5YZU6Y | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| T8ID5YZU6Y | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| T8ID5YZU6Y | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| T8ID5YZU6Y | UNII | FDA UNII substance identifier | - | - | openFDA substances |
Showing 4 of 4 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | (R*,R*)-1,4-dimercaptobutane-2,3-diol | 222-468-7 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
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AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
prohibited
Max
-
Category
Cosmetic Ingredient
Frequently Asked Questions
What regulatory lists include Dithiothreitol?
Dithiothreitol appears on 2 regulatory/inventory lists including Canada; consumer_product; Substances in Products - Canada (4/2014), pharmaceutical. Source: EPA CPDat.
Is Dithiothreitol used in cosmetics?
Yes, Dithiothreitol is also indexed as a cosmetic ingredient under the name Dithiothreitol (DTT). View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Dithiothreitol come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB. All data traces to primary regulatory sources and is updated from official government databases.
Does Dithiothreitol have different safety status in cosmetics vs industrial chemicals?
Dithiothreitol is prohibited in EU cosmetics but has active industrial GHS classifications (H302, H315, H318, H319, H335, H412, H312).
Is Dithiothreitol used outside industrial chemicals?
Dithiothreitol also appears in cosmetics databases.