NOAEL Data REACH Registered Cosmetic Ingredient

C.I. Acid Red 52

Also known as: Food Red 106, Acid Leather Red KB, EINECS 222-529-8, Lissamine Rhodamine, UNII-821LWZ3R6R (+1 more)

CAS 3520-42-1

C.I. Acid Red 52 (CAS 3520-42-1) is a chemical substance. Key regulatory status: REACH registered, 18 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, SCCS, ECHA REACH.

View cosmetic safety profile for CI 45100 →

SOURCE NOAEL studies
NOAEL studies
19
SOURCE Chemical inventory jurisdictions
Regulatory lists
18
SOURCE EU CLP Annex VI
GHS signal
Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 10 fields
Name
C.I. Acid Red 52
CAS Number
3520-42-1
Molecular Formula
C27H30N2O7S2.Na
InChI Key
SXQCTESRRZBPHJ-UHFFFAOYSA-M
Synonyms
Food Red 106Acid Leather Red KBEINECS 222-529-8Lissamine RhodamineUNII-821LWZ3R6RC.I. 45100

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 60 records
DyeFragrance

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 18 records
ListKeywordSource
Europe; Personal care - hair coloringDanish Environmental Protection AgencyDanish EPA
Europe; Personal care - hair coloringDanish Environmental Protection AgencyDanish EPA
Europe; Personal care - hair coloringDanish Environmental Protection AgencyDanish EPA
Europe; Personal care - hair coloringDanish Environmental Protection AgencyDanish EPA
SCIL (9/2019)USEPASafer Chemical Ingredients List
children; Europe; Personal careDanish Environmental Protection AgencyDanish EPA
children; Europe; Personal care - body hygiene - body washDanish Environmental Protection AgencyDanish EPA
children; Europe; Personal care - hair styling and care - shampooDanish Environmental Protection AgencyDanish EPA
children; Europe; Personal careDanish Environmental Protection AgencyDanish EPA
children; Europe; Personal careDanish Environmental Protection AgencyDanish EPA
Arts and crafts/Office supplies - body paint; detected; EuropeDanish Environmental Protection AgencyDanish EPA
Arts and crafts/Office supplies - body paint; detected; EuropeDanish Environmental Protection AgencyDanish EPA
Cleaning products and household care - laundry and fabric treatment - laundry detergent; EuropeDanish EPADanish EPA
Cleaning products and household care; EuropeDanish EPADanish EPA
inert_ingredient; non_food_use; PesticidesEPACPCat
Europe; Personal care; restrictedEuropean CommissionCosIng
IFRA TransparencyIFRAIFRA
SCIL (9/2019)USEPASafer Chemical Ingredients List

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 19 of 19 studies
ValueUnitEndpointRouteSpeciesSource
=1000mg/kg--humanRegulatory source
1000mg/kg---Regulatory source
1000mg/kg bw/day--humanRegulatory source
821LWZ3R6RUNIIFDA UNII substance identifier--openFDA substances
100mg/kg bw/dayLOAELoralratCOSMOS DB
=0.013mg/kg bwNOAELoralratSCCS Opinion
=1000mg/kg bw/dayNOAELoralRatECHA
=1000mg/kg bw/dayNOAELoral-SCCS Opinion
=1000mg/kg bwNOAELoralratSCCS Opinion
=1000mg/kg bw/dayNOAELoralrabbitSCCNFP Opinion
=1000mg/kgNOAEL-humanSCCNFP Opinion
=2000mg/kg bw/dayNOELoralMouseToxValDB ECOTOX
=0.013mg/kg bwdermal absorptionoralratRegulatory source
1000mg/kg bw/daydermal absorption-pigRegulatory source
=1000mg/kg bwdermal absorptionoralratRegulatory source
1000mg/kg bw/daygenotoxicityoral-Regulatory source
1000mg/kg bw/dayirritationoral-Regulatory source
1000mg/kg bw/dayirritationoral-Regulatory source
1000mg/kg bw/dayrepeated dose toxicityoralrabbitRegulatory source

Showing 19 of 19 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA 1 records
StatusNameEC NumberLink
RegisteredHydrogen 3,6-bis(diethylamino)-9-(2,4-disulphonatophenyl)xanthylium, sodium salt222-529-8ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records
Inventory Status
listed

SCCS Opinions

EU Scientific Committee opinions tied to the matched substance.

SOURCE SCCS Opinion 2 opinions
OpinionDateConclusionMax Conc.Concerns
SCCP/1143/0824 June 2008safe0.6%sensitisation potential not excluded
SCCP/1115/072008-06-24The SCCP is of the opinion that the use of Acid Red 52 as an ingredient in oxidative hair dye formulations, at a maximum concentration of 1.5% on the head or in non-oxidative hair dye formulations at a maximum concentration of 0.6% on the head, does not pose any risk to the health of the consumer. Its use as a colorant was not evaluated.1.5% (oxidative hair dye on the head); 0.6% (non-oxidative hair dye on the head)Use as a general colorant was not evaluated (only hair dye use assessed).

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Colorants
View full cosmetic safety profile →

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE ChEMBL / DailyMed CHEMBL1306565
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
4
View full pharmaceutical profile →

Frequently Asked Questions

What is the NOAEL for C.I. Acid Red 52?

C.I. Acid Red 52 has 19 NOAEL studies in the database. The lowest reported value is 0.013 mg/kg bw via oral in rat. Source: SCCS Opinion.

What regulatory lists include C.I. Acid Red 52?

C.I. Acid Red 52 appears on 11 regulatory/inventory lists including Europe; Personal care - hair coloring, SCIL (9/2019), children; Europe; Personal care, and 8 more. Source: EPA CPDat.

Is C.I. Acid Red 52 used in cosmetics?

Yes, C.I. Acid Red 52 is also indexed as a cosmetic ingredient under the name CI 45100. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for C.I. Acid Red 52 come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.

Is C.I. Acid Red 52 used outside industrial chemicals?

C.I. Acid Red 52 also appears in cosmetics, pharmaceutical databases.