Good Cosmetic Ingredient NOAEL Data

CI 45100

CAS Number
3520-42-1
Function
Colorant
Safety Rating
GOOD

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status prohibited
US Notes Not listed as an approved FDA D&C or FD&C color additive for cosmetics in the US.

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

1 study endpoint found for CI 45100. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
LOAEL 100 mg/kg bw/day oral rat Subchronic COSMOS_DB

Expert Verdict

Not approved for cosmetic use in the US; permitted in EU.

⚠️
Concern Level: Low

Regulatory Flags

rinse-off-only not-fda-approved synthetic-dye xanthene-dye sccp-assessed-safe eu_children_restricted epa_safer_alternative ifra_fragrance eu_cosing_listed

Frequently Asked Questions

Is CI 45100 safe in cosmetics?

Not approved for cosmetic use in the US; permitted in EU. The EU classifies CI 45100 as "permitted". Safety rating: GOOD. 1 toxicological study endpoint(s) are available in our database.

Is CI 45100 allowed in the EU?

CI 45100 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does CI 45100 do in cosmetics?

CI 45100 functions as: Colorant. It is classified as a cosmetic ingredient in our database. CAS number: 3520-42-1.

What is the Margin of Safety for CI 45100?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for CI 45100?

The NOAEL (No Observed Adverse Effect Level) for CI 45100 is 100 mg/kg bw/day based on a Subchronic study via oral route in rat. Source: COSMOS_DB.

Compliance Tools

Check CI 45100 compliance across multiple jurisdictions:

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Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
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Substance Compliance
Check compliance across 55 jurisdictions
 🧮
MoS Calculator
Calculate Margin of Safety using SCCS methodology
 ⚗️
Heavy Metal Limits
Compare limits across jurisdictions

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