Is CI 45100 safe in cosmetics?
CI 45100 has a safety rating of "GOOD" in our database. EU status: permitted. US status: prohibited. 10 toxicological study endpoint(s) are available in our database.
CI 45100
Also known as: Food Red 106, Acid Leather Red KB, EINECS 222-529-8, Lissamine Rhodamine, UNII-821LWZ3R6R (+1 more)
CI 45100 (CAS 3520-42-1) is a cosmetic cosmetic ingredient functioning as Colorant. NOAEL 1000 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 3520-42-1 →
Auto-generated CPSR Part A draft with source citations
Chemistry & Identifiers
IUPAC Name
sodium 4-[3-(diethylamino)-6-diethylazaniumylidenexanthen-9-yl]benzene-1,3-disulfonate
InChIKey
SXQCTESRRZBPHJ-UHFFFAOYSA-M
Regulatory Status
EU EU Status
permitted
US US Status
prohibited
US Notes
Not listed as an approved FDA D&C or FD&C color additive for cosmetics in the US.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for CI 45100.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
10 study endpoints found for CI 45100. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =1000 mg/kg bw/day | oral | rabbit | repeated dose toxicity | SCCNFP_vision_codex |
| NOAEL | =1000 mg/kg | - | human | NOAEL study | SCCNFP_vision_codex |
| NOAEL | =1000 mg/kg bw/day | oral | rabbit | repeated dose toxicity | SCCNFP_vision_codex |
| NOAEL | =1000 mg/kg | - | human | NOAEL study | SCCNFP_vision_codex |
| NOAEL | =1000 mg/kg bw/day | oral | rabbit | repeated dose toxicity | SCCNFP_vision_codex |
| NOAEL | =1000 mg/kg | - | human | NOAEL study | SCCNFP_vision_codex |
| NOAEL | =1000 mg/kg bw/day | oral | rabbit | repeated dose toxicity | SCCNFP_vision_codex |
| NOAEL | =1000 mg/kg | - | human | NOAEL study | SCCNFP_vision_codex |
| NOAEL | =0.013 mg/kg bw | oral | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =0.013 mg/kg bw | oral | rat | dermal absorption | SCCS_vision_codex |
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for CI 45100 across SCCS product categories, with measured dermal absorption where available.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10 - 100 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
EU CosIng Annex Listing
European Commission CosIng database Annex references per Regulation (EC) No 1223/2009.
Annex IV — Permitted Colorants
Product type: Red
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
SA Saudi SFDA (III - Restricted)
Product type: (a) Hair dye substance in oxidative hair dye products (b) Hair dye substance in non-oxidative hair dye products. Max: (b) 0.6%.
BRIN Brazil/India Cosmetics
India: Restricted · max (b) 0.6%
India: Permitted Colorant
Additional Jurisdictional Restrictions (1)
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| ASEAN | permitted_colorant | - | All products |
Expanded Dermal Absorption Data
Cross-database dermal penetration: EPA Dryad physics-based, Roberts Mendeley permeation, and SCCS-aggregated measured values.
Aggregated DA Values (1 records across 5 sources)
| Type | DA % | Method | Skin Model | SCCS Ref |
|---|---|---|---|---|
| measured | 85.0% | - | - | SCCP/0137 |
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Dye
Fragrance
Regulatory List Membership (4)
EU Restricted for Children (Cosmetics)
IFRA Fragrance Transparency List
EPA Safer Chemical Ingredients List (SCIL)
EU CosIng Cosmetics Ingredient Database
Expert Verdict
Expert safety assessment and concern-level summary for CI 45100.
Regulatory Flags
rinse-off-only
not-fda-approved
synthetic-dye
xanthene-dye
sccp-assessed-safe
eu_children_restricted
epa_safer_alternative
ifra_fragrance
eu_cosing_listed
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to CI 45100 by CAS number or substance name.
Studies
21
Lowest NOAEL
0.013
Highest NOAEL
1000
Units vary across source rows: mg/kg bw, mg/kg bw/day, mg/kg
SCCS_vision_codex
ToxValDB_ECHA_IUCLID
SCCNFP_vision_codex
Dermal Absorption
View details ->| Absorption % | Method | Vehicle |
|---|---|---|
| 85.0% | - | - |
Known Synonyms
Food Red 106
Acid Leather Red KB
EINECS 222-529-8
Lissamine Rhodamine
UNII-821LWZ3R6R
C.I. 45100
Chemical Function
Dye
Fragrance
Regulatory Lists
Europe; Personal care - hair coloring
Europe; Personal care - hair coloring
Europe; Personal care - hair coloring
Europe; Personal care - hair coloring
SCIL (9/2019)
children; Europe; Personal care
children; Europe; Personal care - body hygiene - body wash
children; Europe; Personal care - hair styling and care - shampoo
children; Europe; Personal care
children; Europe; Personal care
Arts and crafts/Office supplies - body paint; detected; Europe
Arts and crafts/Office supplies - body paint; detected; Europe
Cleaning products and household care - laundry and fabric treatment - laundry detergent; Europe
Cleaning products and household care; Europe
inert_ingredient; non_food_use; Pesticides
Europe; Personal care; restricted
IFRA Transparency
SCIL (9/2019)
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL1306565
Frequently Asked Questions
Is CI 45100 allowed in the EU?
CI 45100 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does CI 45100 do in cosmetics?
CI 45100 functions as: Colorant. It is classified as a cosmetic ingredient in our database. CAS number: 3520-42-1.
What is the NOAEL for CI 45100?
The NOAEL (No Observed Adverse Effect Level) for CI 45100 is =1000 mg/kg bw/day based on a repeated dose toxicity study via oral route in rabbit. A total of 10 study endpoints are available. Source: SCCNFP_vision_codex.
Is CI 45100 used outside cosmetics?
CI 45100 also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check CI 45100 compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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