What is the NOAEL for Perfluorohexane?
Perfluorohexane has 11 NOAEL studies in the database. The lowest reported value is 0.73 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Perfluorohexane
Also known as: Perflexane, 1,1,1,2,2,3,3,4,4,5,5,6,6,6-Tetradecafluorohexane, EINECS 206-585-0, Fluorinert FC72, UNII-FX3WJ41CMX (+8 more)
CAS 355-42-0
Perfluorohexane (CAS 355-42-0) is a chemical substance. Key regulatory status: REACH registered, 7 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
SOURCE
noael studies public
NOAEL studies
11
SOURCE
chemical inventory jurisdictions
Regulatory lists
7
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
19 fields
Name
Perfluorohexane
CAS Number
355-42-0
DTXSID
DTXSID7046548
Molecular Formula
C6F14
InChI Key
ZJIJAJXFLBMLCK-UHFFFAOYSA-N
Monoisotopic Mass
337.977644
Synonyms
Perflexane1,1,1,2,2,3,3,4,4,5,5,6,6,6-TetradecafluorohexaneEINECS 206-585-0Fluorinert FC72UNII-FX3WJ41CMXn-perfluorohexaneAF 0150FC 72PF 5060PFC 51-14PP 1PFC-5-1-14
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
2 records
Solvent
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
7 records
| List | Keyword | Source |
|---|---|---|
| pharmaceutical | US International Trade Commission | CPCat |
| Canada; pharmaceutical | DrugBank | DrugBank |
| CEDI | FDA | United States Food and Drug Administration (FDA) |
| Indirect additives food contact (10/2018) | FDA | United States Food and Drug Administration (FDA) |
| consumer_product; Europe | Danish Environmental Protection Agency | Danish EPA |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| Europe; Personal care - facial cleansing and moisturizing; Personal care - make-up and related | Danish EPA | Danish EPA |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 11 of 11 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =0.73 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| FX3WJ41CMX | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| FX3WJ41CMX | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| FX3WJ41CMX | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| FX3WJ41CMX | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| >5000 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| ~50 | mg/kg bw/day | LEL | injection | Rat | ToxValDB_ECHA_IUCLID |
| ~200 | mg/kg bw/day | LEL | injection | Rat | ToxValDB_ECHA_IUCLID |
| ~50 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| ~100 | mg/kg bw/day | NOAEL | injection | Rat | ToxValDB_ECHA_IUCLID |
| >=200 | mg/kg bw/day | NOAEL | injection | Rat | ToxValDB_ECHA_IUCLID |
Showing 11 of 11 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Tetradecafluorohexane | 206-585-0 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
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CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Solvent
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
PERFLEXANE
ChEMBL Phase
4
Adverse Events
0
Bioactivity
0
Frequently Asked Questions
What regulatory lists include Perfluorohexane?
Perfluorohexane appears on 7 regulatory/inventory lists including pharmaceutical, Canada; pharmaceutical, CEDI, and 4 more. Source: EPA CPDat.
Is Perfluorohexane used in cosmetics?
Yes, Perfluorohexane is also indexed as a cosmetic ingredient under the name Perfluorohexane. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Perfluorohexane come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Is Perfluorohexane used outside industrial chemicals?
Perfluorohexane also appears in cosmetics, pharmaceutical databases.