Is Perfluorohexane safe in cosmetics?
Perfluorohexane has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted.
Moderate
Cosmetic Ingredient
Perfluorohexane
Also known as: Perflexane, 1,1,1,2,2,3,3,4,4,5,5,6,6,6-Tetradecafluorohexane, EINECS 206-585-0, Fluorinert FC72, UNII-FX3WJ41CMX (+8 more)
INCI: PERFLUOROHEXANE
Perfluorohexane (CAS 355-42-0) is a cosmetic cosmetic ingredient functioning as Solvent. NOAEL 50 mg/kg bw/day (PDF-verified against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 355-42-0 →
Auto-generated CPSR Part A draft with source citations
Function
Solvent
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
1,1,1,2,2,3,3,4,4,5,5,6,6,6-tetradecafluorohexane
InChIKey
ZJIJAJXFLBMLCK-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
No specific ban; flagged in PFAS report and by researchers as common unlabeled PFAS in cosmetics
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Perfluorohexane.
Calculate MoS for your specific formulation with the MoS Calculator.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Perfluorohexane across SCCS product categories, with measured dermal absorption where available.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10 - 100 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Solvent
Regulatory List Membership (2)
FDA Substances Added to Food (EAFUS)
FDA Indirect Food Contact Additives
Expert Verdict
Expert safety assessment and concern-level summary for Perfluorohexane.
Regulatory Flags
fda_food_additive
Known Synonyms
Perflexane
1,1,1,2,2,3,3,4,4,5,5,6,6,6-Tetradecafluorohexane
EINECS 206-585-0
Fluorinert FC72
UNII-FX3WJ41CMX
n-perfluorohexane
AF 0150
FC 72
PF 5060
PFC 51-14
PP 1
PFC-5-1-14
C6F14
Chemical Function
Solvent
Regulatory Lists
pharmaceutical
Canada; pharmaceutical
CEDI
Indirect additives food contact (10/2018)
consumer_product; Europe
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
Europe; Personal care - facial cleansing and moisturizing; Personal care - make-up and related
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
PERFLEXANE
ChEMBL ID
CHEMBL1200607
Max Phase
4
Frequently Asked Questions
Is Perfluorohexane allowed in the EU?
Perfluorohexane EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Perfluorohexane do in cosmetics?
Perfluorohexane functions as: Solvent. It is classified as a cosmetic ingredient in our database. CAS number: 355-42-0.
Is Perfluorohexane used outside cosmetics?
Perfluorohexane also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Perfluorohexane compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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