Moderate Cosmetic Ingredient NOAEL Data

Perfluorohexane

INCI: PERFLUOROHEXANE

CAS Number
355-42-0
Function
Solvent
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes No specific ban; flagged in PFAS report and by researchers as common unlabeled PFAS in cosmetics

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
negligible
Sensitization
none

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

1 study endpoint found for Perfluorohexane. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL >=200 mg/kg bw/day other rat oral REACH

Expert Verdict

PFAS compound with volatile properties; inhalation concern noted and commonly unlabeled in cosmetic products despite regulatory oversight gaps.

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Concern Level: Moderate

Regulatory Flags

fda_food_additive

Frequently Asked Questions

Is Perfluorohexane safe in cosmetics?

PFAS compound with volatile properties; inhalation concern noted and commonly unlabeled in cosmetic products despite regulatory oversight gaps. The EU classifies Perfluorohexane as "permitted". Safety rating: MODERATE. 1 toxicological study endpoint(s) are available in our database.

Is Perfluorohexane allowed in the EU?

Perfluorohexane EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Perfluorohexane do in cosmetics?

Perfluorohexane functions as: Solvent. It is classified as a cosmetic ingredient in our database. CAS number: 355-42-0.

What is the Margin of Safety for Perfluorohexane?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Perfluorohexane?

The NOAEL (No Observed Adverse Effect Level) for Perfluorohexane is >=200 mg/kg bw/day based on a oral study via other route in rat. Source: REACH.

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