What is the NOAEL for Benzyl (2E)-2-methylbut-2-enoate?
Benzyl (2E)-2-methylbut-2-enoate has 7 NOAEL studies in the database. The lowest reported value is 67UEP899RR UNII. Source: openFDA substances.
NOAEL Data
Cosmetic Ingredient
Benzyl (2E)-2-methylbut-2-enoate
Also known as: 2-Butenoic acid, 2-methyl-, phenylmethyl ester, (2E)-, 2-Butenoic acid, 2-methyl-, phenylmethyl ester, (E)-, Benzyl 2-methylcrotonate, Benzyl trans-2,3-dimethylacrylate, Benzyl trans-2-methyl-2-butenoate (+8 more)
CAS 37526-88-8
Benzyl (2E)-2-methylbut-2-enoate (CAS 37526-88-8) is a chemical substance. Key regulatory status: 4 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS.
SOURCE
noael studies public
NOAEL studies
7
SOURCE
chemical inventory jurisdictions
Regulatory lists
4
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
19 fields
Name
Benzyl (2E)-2-methylbut-2-enoate
CAS Number
37526-88-8
DTXSID
DTXSID3047130
Molecular Formula
C12H14O2
InChI Key
QRGSTISKDZCDHV-XCVCLJGOSA-N
Monoisotopic Mass
190.09938
Synonyms
2-Butenoic acid, 2-methyl-, phenylmethyl ester, (2E)-2-Butenoic acid, 2-methyl-, phenylmethyl ester, (E)-Benzyl 2-methylcrotonateBenzyl trans-2,3-dimethylacrylateBenzyl trans-2-methyl-2-butenoateBenzyl trans-2-methylcrotonatetrans-2-Butenoic acid, 2-methyl-, phenylmethyl esterEINECS 253-544-8FEMA No. 3330NSC 69098Phenylmethyl 2-methyl-2-butenoate, (E)-UNII-67UEP899RR
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
6 records
FragranceFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
4 records
| List | Keyword | Source |
|---|---|---|
| Europe | European Commission | Fl@vis |
| IFRA Transparency | IFRA | IFRA |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| consumer_product | P&G | Proctor & Gamble |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 7 of 7 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 67UEP899RR | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 67UEP899RR | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 67UEP899RR | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 67UEP899RR | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| - | % | Incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 6750 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| 3 | unitless | Relative reliability score | Dermal | Human | NTP_ICE_skin_sensitization |
Showing 7 of 7 studies
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Fragrance
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CHEMBL3186295
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
0
Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Benzyl (2E)-2-methylbut-2-enoate?
Benzyl (2E)-2-methylbut-2-enoate appears on 4 regulatory/inventory lists including Europe, IFRA Transparency, food_additive; Substances Added to Food (formerly EAFUS) (2/2019), and 1 more. Source: EPA CPDat.
Is Benzyl (2E)-2-methylbut-2-enoate used in cosmetics?
Yes, Benzyl (2E)-2-methylbut-2-enoate is also indexed as a cosmetic ingredient under the name Benzyl Tiglate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Benzyl (2E)-2-methylbut-2-enoate come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is Benzyl (2E)-2-methylbut-2-enoate used outside industrial chemicals?
Benzyl (2E)-2-methylbut-2-enoate also appears in cosmetics, pharmaceutical, cannabis databases.