What is the NOAEL for Hexamidine?
Hexamidine has 25 NOAEL studies in the database. The lowest reported value is 0.4 mg/kg bw/day via dermal in rabbits. Source: UnifiedCodex:CIR:beta.noael_studies.
NOAEL Data
Cosmetic Ingredient
Hexamidine
Also known as: Benzenecarboximidamide, 4,4'-[1,6-hexanediylbis(oxy)]bis-, Benzamidine, 4,4'-(hexamethylenedioxy)di, 1,6-Bis(4-amidinophenoxy)-n-hexane, 1,6-Bis(4-amidinophenoxy)hexane, 4,4-Diamidino-1,6-diphenoxyhexane (+7 more)
CAS 3811-75-4
Hexamidine (CAS 3811-75-4) is a chemical substance. Key regulatory status: 2 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS.
SOURCE
noael studies public
NOAEL studies
25
SOURCE
chemical inventory jurisdictions
Regulatory lists
2
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
18 fields
Name
Hexamidine
CAS Number
3811-75-4
DTXSID
DTXSID60191524
Molecular Formula
C20H26N4O2
InChI Key
OQLKNTOKMBVBKV-UHFFFAOYSA-N
Monoisotopic Mass
354.205576
Synonyms
Benzenecarboximidamide, 4,4'-[1,6-hexanediylbis(oxy)]bis-Benzamidine, 4,4'-(hexamethylenedioxy)di1,6-Bis(4-amidinophenoxy)-n-hexane1,6-Bis(4-amidinophenoxy)hexane4,4-Diamidino-1,6-diphenoxyhexaneDesmodineHexamidine (antiseptic)4,4'-(1,6-Hexanediylbis(oxy))bis-benzenecarboximidamideHexamidinaHexamidinumUNII-3483C2H13H4,4'-(Hexamethylenedioxy)dibenzamidine
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
1 records
Preservative
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
2 records
| List | Keyword | Source |
|---|---|---|
| pharmaceutical | US International Trade Commission | CPCat |
| Canada; pharmaceutical | DrugBank | DrugBank |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 25 of 25 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 0.4 | - | - | dermal | rabbits | UnifiedCodex:CIR:beta.noael_studies |
| 50 | - | - | oral gavage | Sprague-Dawley rats | UnifiedCodex:CIR:beta.noael_studies |
| 50 | - | - | oral gavage | male rats | UnifiedCodex:CIR:beta.noael_studies |
| 3483C2H13H | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 3483C2H13H | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 3483C2H13H | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 3483C2H13H | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| =0.4 | % | NOAEL | dermal | rabbit | CIR_vision_codex |
| =0.4 | - | NOAEL | dermal | rabbits | CIR_vision_codex |
| =0.4 | % | NOAEL | dermal | rabbit | CIR_vision_codex |
| =0.4 | - | NOAEL | dermal | rabbits | CIR_vision_codex |
| =0.4 | % | NOAEL | dermal | rabbit | CIR_vision_codex |
| =0.4 | - | NOAEL | dermal | rabbits | CIR_vision_codex |
| =0.4 | % | NOAEL | dermal | rabbit | CIR_vision_codex |
| =0.4 | - | NOAEL | dermal | rabbits | CIR_vision_codex |
| =50 | mg/kg/day | NOAEL | oral | rat | CIR_vision_codex |
| =50 | - | NOAEL | oral gavage | Sprague-Dawley rats | CIR_vision_codex |
| =50 | mg/kg/day | NOAEL | oral | rat | CIR_vision_codex |
| =50 | - | NOAEL | oral gavage | Sprague-Dawley rats | CIR_vision_codex |
| =50 | mg/kg/day | NOAEL | oral | rat | CIR_vision_codex |
| =50 | - | NOAEL | oral gavage | Sprague-Dawley rats | CIR_vision_codex |
| =50 | mg/kg/day | NOAEL | oral | rat | CIR_vision_codex |
| =50 | - | NOAEL | oral gavage | Sprague-Dawley rats | CIR_vision_codex |
| 0.4 | % | repeated dose toxicity | dermal | rabbit | UnifiedCodex:CIR:beta.noael_studies |
| 50 | mg/kg/day | repeated dose toxicity | oral | rat | UnifiedCodex:CIR:beta.noael_studies |
Showing 25 of 25 studies
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
restricted
Max
0.1%
Category
Preservative
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
HEXAMIDINE
ChEMBL Phase
2
Adverse Events
0
Bioactivity
7
Frequently Asked Questions
What regulatory lists include Hexamidine?
Hexamidine appears on 2 regulatory/inventory lists including pharmaceutical, Canada; pharmaceutical. Source: EPA CPDat.
Is Hexamidine used in cosmetics?
Yes, Hexamidine is also indexed as a cosmetic ingredient under the name Hexamidine. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Hexamidine come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Is Hexamidine used outside industrial chemicals?
Hexamidine also appears in cosmetics, pharmaceutical databases.