NOAEL Data Cosmetic Ingredient

4-(3-((9,10-Dihydro-4-hydroxy-9,10-dioxo-1-anthracenyl)amino)prop- yl)-4-methyl morpholinium methyl sulfate

Also known as: EINECS 254-161-9, UNII-RNJ1LHE5O7, Hydroxyanthraquinone-aminopropyl methyl morpholinium methosulfate

CAS 38866-20-5

4-(3-((9,10-Dihydro-4-hydroxy-9,10-dioxo-1-anthracenyl)amino)prop- yl)-4-methyl morpholinium methyl sulfate (CAS 38866-20-5) is a chemical substance. Key regulatory status: 3 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS.

View cosmetic safety profile for Hydroxyanthraquinoneaminopropyl Methyl Morpholinium Methosulfate →

SOURCE noael studies public
NOAEL studies
51
SOURCE chemical inventory jurisdictions
Regulatory lists
3
SOURCE eu clp annex vi
GHS signal
Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 9 fields
Name
4-(3-((9,10-Dihydro-4-hydroxy-9,10-dioxo-1-anthracenyl)amino)prop- yl)-4-methyl morpholinium methyl sulfate
CAS Number
38866-20-5
DTXSID
DTXSID80192119
Molecular Formula
C22H24N2O4.CH4O4S
InChI Key
JAADWTSKUWWHLE-UHFFFAOYSA-N
Monoisotopic Mass
492.156637
Synonyms
EINECS 254-161-9UNII-RNJ1LHE5O7Hydroxyanthraquinone-aminopropyl methyl morpholinium methosulfate

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 2 records
Dye

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 3 records
ListKeywordSource
Europe; Personal care; restrictedEuropean CommissionCosIng
children; Europe; Personal careDanish Environmental Protection AgencyDanish EPA
Canada; Personal care; Substances in PCP - Canada (4/2014)Government of CanadaCPCat

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 50 of 51 studies
ValueUnitEndpointRouteSpeciesSource
26mg/kg bw/d--humanUnifiedCodex:SCCS_SHADOW:beta.noael_studies
800mg/kg bw/d--humanUnifiedCodex:SCCS_SHADOW:beta.noael_studies
RNJ1LHE5O7UNIIFDA UNII substance identifier--openFDA substances
RNJ1LHE5O7UNIIFDA UNII substance identifier--openFDA substances
RNJ1LHE5O7UNIIFDA UNII substance identifier--openFDA substances
RNJ1LHE5O7UNIIFDA UNII substance identifier--openFDA substances
200mg/kg bw/dayLOAELoralratCOSMOS_DB
=0.015mg/kg bw/dNOAELoralratSCCS_vision_codex
=0.015mg/kg bw/dNOAELoralratSCCS_vision_codex
=0.015mg/kg bw/dNOAELoralratSCCS_vision_codex
=0.015mg/kg bw/dNOAELoralratSCCS_vision_codex
=26mg/kg bw/dNOAEL-humanSCCS_vision_codex
=26mg/kg bw/dNOAEL-humanSCCS_vision_codex
=26mg/kg bw/dNOAEL-humanSCCS_vision_codex
=26mg/kg bw/dNOAEL-humanSCCS_vision_codex
50mg/kg bw/dayNOAELoralratCOSMOS_DB
=50mg/kg bw/dNOAEL--SCCS_vision_codex
=50mg/kg bw/dNOAEL--SCCS_vision_codex
=50mg/kg bw/dNOAEL--SCCS_vision_codex
=50mg/kg bw/dNOAEL--SCCS_vision_codex
=87.5%NOAELoralratSCCS_vision_codex
=87.5%NOAELoralratSCCS_vision_codex
=87.5%NOAELoralratSCCS_vision_codex
=87.5%NOAELoralratSCCS_vision_codex
=200mg/kg bw/dNOAEL--SCCS_vision_codex
=200mg/kgNOAELoralratSCCS_vision_codex
=200mg/kg bw/dNOAEL--SCCS_vision_codex
=200mg/kg bw/dNOAEL--SCCS_vision_codex
=200mg/kgNOAELoralratSCCS_vision_codex
=200mg/kg bw/dNOAEL--SCCS_vision_codex
=200mg/kgNOAELoralratSCCS_vision_codex
=200mg/kg bw/dNOAEL--SCCS_vision_codex
=200mg/kg bw/dNOAEL--SCCS_vision_codex
=200mg/kg bw/dNOAEL--SCCS_vision_codex
=200mg/kgNOAELoralratSCCS_vision_codex
=200mg/kg bw/dNOAEL--SCCS_vision_codex
=800mg/kg bw/dNOAEL-humanSCCS_vision_codex
=800mg/kg bw/dNOAEL-humanSCCS_vision_codex
=800mg/kg bw/dNOAEL-humanSCCS_vision_codex
=800mg/kg bw/dNOAEL-humanSCCS_vision_codex
=0.015mg/kg bw/ddermal absorptionoralratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
=50mg/kg bw/ddermal absorptionoralratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
87.5%dermal absorptionoralratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
=200mg/kgdermal absorptionoralratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
50mg/kg bw/dgenotoxicity--UnifiedCodex:SCCS_SHADOW:beta.noael_studies
200mg/kg bw/dgenotoxicity--UnifiedCodex:SCCS_SHADOW:beta.noael_studies
200mg/kg bw/dgenotoxicity--UnifiedCodex:SCCS_SHADOW:beta.noael_studies
50mg/kg bw/drepeated dose toxicityoralratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
50mg/kg bw/drepeated dose toxicityoralratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
200mg/kg bw/drepeated dose toxicityoralratUnifiedCodex:SCCS_SHADOW:beta.noael_studies

Showing 50 of 51 studies

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records
Inventory Status
listed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB
EU Status
prohibited
Max
0.5%
Category
Colorant
View full cosmetic safety profile →

Frequently Asked Questions

What is the NOAEL for 4-(3-((9,10-Dihydro-4-hydroxy-9,10-dioxo-1-anthracenyl)amino)prop- yl)-4-methyl morpholinium methyl sulfate?

4-(3-((9,10-Dihydro-4-hydroxy-9,10-dioxo-1-anthracenyl)amino)prop- yl)-4-methyl morpholinium methyl sulfate has 51 NOAEL studies in the database. The lowest reported value is 26 mg/kg bw/d in human. Source: UnifiedCodex:SCCS_SHADOW:beta.noael_studies.

What regulatory lists include 4-(3-((9,10-Dihydro-4-hydroxy-9,10-dioxo-1-anthracenyl)amino)prop- yl)-4-methyl morpholinium methyl sulfate?

4-(3-((9,10-Dihydro-4-hydroxy-9,10-dioxo-1-anthracenyl)amino)prop- yl)-4-methyl morpholinium methyl sulfate appears on 3 regulatory/inventory lists including Europe; Personal care; restricted, children; Europe; Personal care, Canada; Personal care; Substances in PCP - Canada (4/2014). Source: EPA CPDat.

Is 4-(3-((9,10-Dihydro-4-hydroxy-9,10-dioxo-1-anthracenyl)amino)prop- yl)-4-methyl morpholinium methyl sulfate used in cosmetics?

Yes, 4-(3-((9,10-Dihydro-4-hydroxy-9,10-dioxo-1-anthracenyl)amino)prop- yl)-4-methyl morpholinium methyl sulfate is also indexed as a cosmetic ingredient under the name Hydroxyanthraquinoneaminopropyl Methyl Morpholinium Methosulfate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for 4-(3-((9,10-Dihydro-4-hydroxy-9,10-dioxo-1-anthracenyl)amino)prop- yl)-4-methyl morpholinium methyl sulfate come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, CosIng / Ingredients DB. All data traces to primary regulatory sources and is updated from official government databases.

Does 4-(3-((9,10-Dihydro-4-hydroxy-9,10-dioxo-1-anthracenyl)amino)prop- yl)-4-methyl morpholinium methyl sulfate have different safety status in cosmetics vs industrial chemicals?

4-(3-((9,10-Dihydro-4-hydroxy-9,10-dioxo-1-anthracenyl)amino)prop- yl)-4-methyl morpholinium methyl sulfate is prohibited in EU cosmetics at max 0.5% but has active industrial GHS classifications (H302, H317).

Is 4-(3-((9,10-Dihydro-4-hydroxy-9,10-dioxo-1-anthracenyl)amino)prop- yl)-4-methyl morpholinium methyl sulfate used outside industrial chemicals?

4-(3-((9,10-Dihydro-4-hydroxy-9,10-dioxo-1-anthracenyl)amino)prop- yl)-4-methyl morpholinium methyl sulfate also appears in cosmetics databases.