Moderate Cosmetic Ingredient NOAEL Data

Hydroxyanthraquinoneaminopropyl Methyl Morpholinium Methosulfate

INCI: HYDROXYANTHRAQUINONEAMINOPROPYL METHYL MORPHOLINIUM METHOSULFATE

CAS Number
38866-20-5
Function
Hair dye (non-oxidative) — cationic anthraquinone colorant
Safety Rating
MODERATE

Regulatory Status

🇪🇺 EU Status prohibited
EU Max Conc. 0.5%
🇺🇸 US Status permitted
US Notes Permitted — coal-tar hair dye exemption under FD&C Act §601(a); no specific CFR restriction

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
moderate
Sensitization
high

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

2 study endpoints found for Hydroxyanthraquinoneaminopropyl Methyl Morpholinium Methosulfate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 50 mg/kg bw/day oral rat Subchronic COSMOS_DB
LOAEL 200 mg/kg bw/day oral rat Subchronic COSMOS_DB

Expert Verdict

Strong sensitiser with secondary amine prone to nitrosation; must not be combined with nitrosating agents; GHS H302 (harmful if swallowed)

⚠️
Concern Level: High

Regulatory Flags

colorant eu_children_restricted eu_cosing_listed

Frequently Asked Questions

Is Hydroxyanthraquinoneaminopropyl Methyl Morpholinium Methosulfate safe in cosmetics?

Strong sensitiser with secondary amine prone to nitrosation; must not be combined with nitrosating agents; GHS H302 (harmful if swallowed) The EU classifies Hydroxyanthraquinoneaminopropyl Methyl Morpholinium Methosulfate as "prohibited". Safety rating: MODERATE. 2 toxicological study endpoint(s) are available in our database.

Is Hydroxyanthraquinoneaminopropyl Methyl Morpholinium Methosulfate allowed in the EU?

Hydroxyanthraquinoneaminopropyl Methyl Morpholinium Methosulfate EU regulatory status: prohibited. Maximum allowed concentration: 0.5%. This is based on EU Regulation 1223/2009 and its amendments.

What does Hydroxyanthraquinoneaminopropyl Methyl Morpholinium Methosulfate do in cosmetics?

Hydroxyanthraquinoneaminopropyl Methyl Morpholinium Methosulfate functions as: Hair dye (non-oxidative) — cationic anthraquinone colorant. It is classified as a cosmetic ingredient in our database. CAS number: 38866-20-5.

What is the Margin of Safety for Hydroxyanthraquinoneaminopropyl Methyl Morpholinium Methosulfate?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Hydroxyanthraquinoneaminopropyl Methyl Morpholinium Methosulfate?

The NOAEL (No Observed Adverse Effect Level) for Hydroxyanthraquinoneaminopropyl Methyl Morpholinium Methosulfate is 50 mg/kg bw/day based on a Subchronic study via oral route in rat. A total of 2 study endpoints are available. Source: COSMOS_DB.

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