Also known as: EINECS 254-161-9, UNII-RNJ1LHE5O7, Hydroxyanthraquinone-aminopropyl methyl morpholinium methosulfate
INCI: HYDROXYANTHRAQUINONEAMINOPROPYL METHYL MORPHOLINIUM METHOSULFATE
Hydroxyanthraquinoneaminopropyl Methyl Morpholinium Methosulfate (CAS 38866-20-5) is a cosmetic cosmetic ingredient functioning as Hair dye (non-oxidative) — cationic anthraquinone colorant. Reported NOAEL =0.015 mg/kg bw/d in rat (SCCS_vision_codex); EU Regulation 1223/2009 status: prohibited, max 0.5%. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 38866-20-5 →
Hydroxyanthraquinoneaminopropyl Methyl Morpholinium Methosulfate is prohibited in EU cosmetics at max 0.5% but has active industrial GHS classifications (H302, H317).
Source: Cosmetics: ingredients.eu_status/eu_max; Chemicals: ghs_classifications.signal_word/hazard_statement_code
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Margin of Safety, dermal absorption, and sensitization profile summaries for Hydroxyanthraquinoneaminopropyl Methyl Morpholinium Methosulfate.
Calculate MoS for your specific formulation with the MoS Calculator.
10 study endpoints found for Hydroxyanthraquinoneaminopropyl Methyl Morpholinium Methosulfate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =0.015 mg/kg bw/d | oral | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =0.015 mg/kg bw/d | oral | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =0.015 mg/kg bw/d | oral | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =0.015 mg/kg bw/d | oral | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =26 mg/kg bw/d | - | human | NOAEL study | SCCS_vision_codex |
| NOAEL | =26 mg/kg bw/d | - | human | NOAEL study | SCCS_vision_codex |
| NOAEL | =26 mg/kg bw/d | - | human | NOAEL study | SCCS_vision_codex |
| NOAEL | =26 mg/kg bw/d | - | human | NOAEL study | SCCS_vision_codex |
| NOAEL | =50 mg/kg bw/d | - | - | genotoxicity | SCCS_vision_codex |
| NOAEL | =50 mg/kg bw/d | - | - | genotoxicity | SCCS_vision_codex |
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
Cross-database dermal penetration: EPA Dryad physics-based, Roberts Mendeley permeation, and SCCS-aggregated measured values.
| Type | DA % | Method | Skin Model | SCCS Ref |
|---|---|---|---|---|
| measured_sccs_opinion | 1.52% | - | - | SCCS/1505/13 |
Expert safety assessment and concern-level summary for Hydroxyanthraquinoneaminopropyl Methyl Morpholinium Methosulfate.
Public NOAEL study rows linked to Hydroxyanthraquinoneaminopropyl Methyl Morpholinium Methosulfate by CAS number or substance name.
Units vary across source rows: mg/kg bw/d, mg/kg
| Absorption % | Method | Vehicle |
|---|---|---|
| 1.52% | SCCS opinion extraction | - |
Hydroxyanthraquinoneaminopropyl Methyl Morpholinium Methosulfate has a safety rating of "MODERATE" in our database. EU status: prohibited. US status: permitted. 10 toxicological study endpoint(s) are available in our database.
Hydroxyanthraquinoneaminopropyl Methyl Morpholinium Methosulfate EU regulatory status: prohibited. Maximum allowed concentration: 0.5%. This is based on EU Regulation 1223/2009 and its amendments.
Hydroxyanthraquinoneaminopropyl Methyl Morpholinium Methosulfate functions as: Hair dye (non-oxidative) — cationic anthraquinone colorant. It is classified as a cosmetic ingredient in our database. CAS number: 38866-20-5.
The NOAEL (No Observed Adverse Effect Level) for Hydroxyanthraquinoneaminopropyl Methyl Morpholinium Methosulfate is =0.015 mg/kg bw/d based on a dermal absorption study via oral route in rat. A total of 10 study endpoints are available. Source: SCCS_vision_codex.
Hydroxyanthraquinoneaminopropyl Methyl Morpholinium Methosulfate also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Hydroxyanthraquinoneaminopropyl Methyl Morpholinium Methosulfate is prohibited in EU cosmetics at max 0.5% but has active industrial GHS classifications (H302, H317).
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