NOAEL Data Cosmetic Ingredient

Capsaicin

Also known as: Qutenza, (6E)-N-[(4-Hydroxy-3-methoxyphenyl)methyl]-8-methyl-6-nonenamide, Adlea, ALGRX 4975, Ausanil (+14 more)

CAS 404-86-4

Capsaicin (CAS 404-86-4) is a chemical substance. Key regulatory status: 18 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS.

View cosmetic safety profile for CAPSAICIN →

SOURCE NOAEL studies
NOAEL studies
78
SOURCE Chemical inventory jurisdictions
Regulatory lists
18
SOURCE EU CLP Annex VI
GHS signal
Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 24 fields
Name
Capsaicin
CAS Number
404-86-4
Molecular Formula
C18H27NO3
InChI Key
YKPUWZUDDOIDPM-SOFGYWHQSA-N
Monoisotopic Mass
305.199094
Synonyms
Qutenza(6E)-N-[(4-Hydroxy-3-methoxyphenyl)methyl]-8-methyl-6-nonenamideAdleaALGRX 4975AusanilAxsainCapsicinChilli OrangeOvocaptrans-CapsaicinN-(4-oxy-3-methoxybenzyl)-8-methyl-6-nonenamide(6E)-N-[(4-hydroxy-3-methoxyphenyl)methyl]-8-methylnon-6-enamide

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 8 records
DeodorizerSoftener and conditionerFragrancePharmaceuticalFlavouring and nutrient

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 18 records
ListKeywordSource
Canada; consumer_product; Substances in Products - Canada (4/2014)Government of CanadaCPCat
active_ingredient; agricultural; applied; PesticidesArizona Department of Environmental QualityState of Arizona
active_ingredient; agricultural; applied; PesticidesArizona Department of Environmental QualityState of Arizona
pharmaceuticalFDAUnited States Food and Drug Administration (FDA)
pharmaceuticalFDAUnited States Food and Drug Administration (FDA)
pharmaceuticalFDAUnited States Food and Drug Administration (FDA)
pharmaceuticalFDAUnited States Food and Drug Administration (FDA)
active_ingredient; agricultural; PesticidesUSDAUnited States Department of Agriculture (USDA)
active_ingredient; agricultural; PesticidesUSDAUnited States Department of Agriculture (USDA)
active_ingredient; agricultural; PesticidesUSDAUnited States Department of Agriculture (USDA)
active_ingredient; agricultural; applied; fruits_and_vegetables; PesticidesUSDAUnited States Department of Agriculture (USDA)
active_ingredient; agricultural; PesticidesUSDAUnited States Department of Agriculture (USDA)
active_ingredient; agricultural; PesticidesUSDAUnited States Department of Agriculture (USDA)
Europe; pharmaceuticalEuropean Medicines AgencyPROTECT ADR database
air; Cleaning products and household care - air freshener; detected; emissions; EuropeDanish Environmental Protection AgencyDanish EPA
Canada; pharmaceuticalDrugBankDrugBank
Cleaning products and household care - air freshener; EuropeDanish Environmental Protection AgencyDanish EPA
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)FDAUnited States Food and Drug Administration (FDA)

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 50 of 78 studies
ValueUnitEndpointRouteSpeciesSource
=1.7mg/kg bw/dayADI-ConsumersEFSA
=24mg/kg bw/dayADI-ConsumersEFSA
S07O44R1ZMUNIIFDA UNII substance identifier--openFDA substances
=148mg/kg bwLD50oralRat (Female)NTP ICE acute oral
=161mg/kg bwLD50oralRat (Male)NTP ICE acute oral
=5.000e-7mmolLOELinjectionMouseToxValDB ECOTOX
=0.00048mgLOELinjectionRatToxValDB ECOTOX
=0.001mg/orgLOELinjectionMouseToxValDB ECOTOX
=0.003ml/cm2LOELdermalEuropean RabbitToxValDB ECOTOX
=0.0065ml/cm2LOELdermalEuropean RabbitToxValDB ECOTOX
=0.01mg/orgLOELinjectionRatToxValDB ECOTOX
=0.015mg/orgLOELinjectionRatToxValDB ECOTOX
=0.015mgLOELinjectionRatToxValDB ECOTOX
=0.025mgLOELinjectionDogToxValDB ECOTOX
=0.04mgLOELinjectionRatToxValDB ECOTOX
=0.05mg/kg bw/dayLOELoralRatToxValDB ECOTOX
=0.07mgLOELinjectionRatToxValDB ECOTOX
=0.1mg/kg bw/dayLOELinjectionRatToxValDB ECOTOX
=0.1%LOELdermalRatToxValDB ECOTOX
=0.2mg/kg bw/dayLOELinjectionRatToxValDB ECOTOX
=0.2mgLOELinjectionEuropean RabbitToxValDB ECOTOX
=0.3mg/kg bw/dayLOELinjectionDogToxValDB ECOTOX
=0.4mgLOELinjectionRatToxValDB ECOTOX
=0.5mg/dayLOELinjectionRatToxValDB ECOTOX
=0.5%LOELdermalDogToxValDB ECOTOX
=1%LOELdermalRatToxValDB ECOTOX
=1.8mg/kg bw/dayLOELinjectionMouseToxValDB ECOTOX
=1.94mg/kg bw/dayLOELinjectionMouseToxValDB ECOTOX
=3mg/kg bw/dayLOELinjectionRatToxValDB ECOTOX
=3%LOELinjectionRatToxValDB ECOTOX
=5mg/kg bw/dayLOELinjectionRatToxValDB ECOTOX
=7.5mg/kg bw/dayLOELinjectionMouseToxValDB ECOTOX
=10mg/kg bw/dayLOELinjectionRatToxValDB ECOTOX
=16mg/orgLOELdermalRatToxValDB ECOTOX
=25mg/kg bw/dayLOELinjectionRatToxValDB ECOTOX
=30mg/LLOELdermalDogToxValDB ECOTOX
=30mg/kg bw/dayLOELinjectionDogToxValDB ECOTOX
=32mg/orgLOELdermalRatToxValDB ECOTOX
=40mMLOELinjectionRatToxValDB ECOTOX
=40mg/kg bw/dayLOELoralRatToxValDB ECOTOX
=50mg/kg bw/dayLOELinjectionRatToxValDB ECOTOX
=90mg/kg bw/dayLOELinjectionRatToxValDB ECOTOX
=125mg/kg bw/dayLOELinjectionRatToxValDB ECOTOX
=130mg/kg bw/dayLOELinjectionRatToxValDB ECOTOX
=150mg/kg bw/dayLOELinjectionRatToxValDB ECOTOX
=300mg/kg bw/dayLOELinjectionRatToxValDB ECOTOX
=950mg/kg bw/dayLOELinjectionRatToxValDB ECOTOX
=4600mg/kg bw/dayLOELinjectionRatToxValDB ECOTOX
=5000mg/kg bw/dayLOELinjectionRatToxValDB ECOTOX
=3.000e+4mg/kg bw/dayLOELinjectionRatToxValDB ECOTOX

Showing 50 of 78 studies

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records
Inventory Status
listed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Fragrance
View full cosmetic safety profile →

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE ChEMBL / DailyMed CAPSAICIN
ChEMBL Phase
4
Adverse Events
1576
Bioactivity
21
View full pharmaceutical profile →

Food Safety Data

Same-CAS food additive, ADI, and GRAS records where available.

SOURCE EFSA 1 records

1 food-safety record found.

View full food safety profile →

Cannabis Data

Same-CAS cannabis compliance and lab records where available.

SOURCE Cannabis regulatory / lab data efsa substances

1 cannabis record found in efsa substances.

View full cannabis profile →

Frequently Asked Questions

What is the NOAEL for Capsaicin?

Capsaicin has 78 NOAEL studies in the database. The lowest reported value is 2.500e-8 mmol via injection in Mouse. Source: ToxValDB ECOTOX.

What regulatory lists include Capsaicin?

Capsaicin appears on 10 regulatory/inventory lists including Canada; consumer_product; Substances in Products - Canada (4/2014), active_ingredient; agricultural; applied; Pesticides, pharmaceutical, and 7 more. Source: EPA CPDat.

Is Capsaicin used in cosmetics?

Yes, Capsaicin is also indexed as a cosmetic ingredient under the name CAPSAICIN. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for Capsaicin come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.

Does Capsaicin have different safety status in cosmetics vs industrial chemicals?

Capsaicin is classified GHS Danger (H301, H315, H317, H319, H334, H335, H302, H318) in the chemicals database but is allowed in EU cosmetics.

Is Capsaicin used outside industrial chemicals?

Capsaicin also appears in cosmetics, pharmaceutical, food safety, cannabis databases.