CAPSAICIN
Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
10 study endpoints found for CAPSAICIN. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 1500 mg/kg bw/day | oral | mouse | Short Term Toxicity | COSMOS_DB |
| NOAEL | 50 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 1 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 3.4 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 4.4 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| NOAEL | 40 mg/kg bw/day | oral | rat | Special Toxicology Study | COSMOS_DB |
| NOAEL | 25 mg/kg bw/day | oral | rat | Chronic | COSMOS_DB |
| NOAEL | 15 mg/kg bw/day | oral | mouse | Immunotoxicology | COSMOS_DB |
| dose_tested | 1500 mg/kg bw/day | oral | mouse | Short Term Toxicity | COSMOS_DB |
| dose_tested | 1 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
Expert Verdict
CAPSAICIN is listed in the EU CosIng database with functions: Fragrance, Skin Conditioning It is permitted in the EU without specific restrictions.
Regulatory Flags
Frequently Asked Questions
Is CAPSAICIN safe in cosmetics?
CAPSAICIN is listed in the EU CosIng database with functions: Fragrance, Skin Conditioning It is permitted in the EU without specific restrictions. The EU classifies CAPSAICIN as "Permitted". Safety rating: GOOD. 10 toxicological study endpoint(s) are available in our database.
Is CAPSAICIN allowed in the EU?
CAPSAICIN EU regulatory status: Permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does CAPSAICIN do in cosmetics?
CAPSAICIN functions as: Fragrance, Skin Conditioning. It is classified as a cosmetic ingredient in our database. CAS number: 404-86-4.
What is the Margin of Safety for CAPSAICIN?
NOAEL: 60 mg/kg bw/day (oral) | Source: EFSA FEEDAP Panel “Safety and efficacy of a feed additive consisting of capsaicin for all animal ... The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for CAPSAICIN?
The NOAEL (No Observed Adverse Effect Level) for CAPSAICIN is 1500 mg/kg bw/day based on a Short Term Toxicity study via oral route in mouse. A total of 10 study endpoints are available. Source: COSMOS_DB.
Compliance Tools
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