NOAEL Data REACH Registered Cosmetic Ingredient

Sulisobenzone

Also known as: 2-Hydroxy-4-methoxy-5-sulfobenzophenone, Benzenesulfonic acid, 5-benzoyl-4-hydroxy-2-methoxy-, Benzophenone 4, 2-Hydroxy-4-methoxybenzophenone-5-sulfonic acid, BRN 2889165 (+3 more)

CAS 4065-45-6

Sulisobenzone (CAS 4065-45-6) is a chemical substance. Key regulatory status: REACH registered, 9 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, SCCS, ECHA REACH.

View cosmetic safety profile for Sulisobenzone (Benzophenone-4) →

Cross-Vertical Regulatory Divergence

Sulisobenzone is classified GHS Danger (H315, H317, H318, H319, H335) in the chemicals database but is allowed in EU cosmetics.

SOURCE Cross-vertical comparison Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code

SOURCE NOAEL studies

NOAEL studies

SOURCE Chemical inventory jurisdictions

Regulatory lists

SOURCE EU CLP Annex VI

GHS signal

Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 13 fields

Name

Sulisobenzone

CAS Number

4065-45-6

Molecular Formula

C14H12O6S

InChI Key

CXVGEDCSTKKODG-UHFFFAOYSA-N

Monoisotopic Mass

308.035459

Synonyms

2-Hydroxy-4-methoxy-5-sulfobenzophenoneBenzenesulfonic acid, 5-benzoyl-4-hydroxy-2-methoxy-Benzophenone 42-Hydroxy-4-methoxybenzophenone-5-sulfonic acidBRN 2889165EINECS 223-772-2Uvinuc ms 40UNII-1W6L629B4K

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 60 records

UV stabilizerFragrance

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 9 records

List	Keyword	Source
inert_ingredient; non_food_use; Pesticides	EPA	CPCat
IFRA Transparency	IFRA	IFRA
Canada; consumer_product; Substances in Products - Canada (4/2014)	Government of Canada	CPCat
children; Europe; Personal care - body hygiene - body wash	Danish Environmental Protection Agency	Danish EPA
children; Europe; Personal care - hair styling and care - shampoo	Danish Environmental Protection Agency	Danish EPA
children; Europe; Personal care	Danish Environmental Protection Agency	Danish EPA
children; Europe; Personal care	Danish Environmental Protection Agency	Danish EPA
pharmaceutical	US International Trade Commission	CPCat
Canada; pharmaceutical	DrugBank	DrugBank

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 20 of 20 studies

Value	Unit	Endpoint	Route	Species	Source
59	-	-	-	-	Regulatory source
620	-	-	-	-	Regulatory source
620	-	-	dermal	-	Regulatory source
1239	mg/kg/day	-	-	rat	Regulatory source
1250	mg/kg/day	-	-	rat	Regulatory source
1.05	uL/min/10^6 cells	Clint	-	Human	NTP ICE adme parameters
=10	mg/m3	DNEL systemic	inhalation	Human	ToxValDB GESTIS DNEL
=61.7	mg/m3	DNEL systemic	inhalation	Human	ToxValDB GESTIS DNEL
1W6L629B4K	UNII	FDA UNII substance identifier	-	-	openFDA substances
0.00942	fraction	Fu	-	Human	NTP ICE adme parameters
=3530	mg/kg bw	LD50	oral	Rat	NTP ICE acute oral
0	unitless	Model Score	-	-	NTP ICE endocrine
=59	-	NOAEL	-	-	SCCS Opinion
=620	mg/kg bw/day	NOAEL	oral	rat	SCCS Opinion
=620	-	NOAEL	-	-	SCCS Opinion
=1239	mg/kg/day	NOAEL	-	rat	SCCS Opinion
=1239	mg/kg bw/day	NOAEL	oral	rat	SCCS Opinion
=1250	mg/kg/day	NOAEL	-	rat	SCCS Opinion
620	mg/kg bw/day	repeated dose toxicity	oral	rat	Regulatory source
1239	mg/kg bw/day	repeated dose toxicity	oral	rat	Regulatory source

Showing 20 of 20 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA 1 records

Status	Name	EC Number	Link
Registered	Sulisobenzone	223-772-2	ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records

Inventory Status

listed

SCCS Opinions

EU Scientific Committee opinions tied to the matched substance.

SOURCE SCCS Opinion 1 opinions

Opinion	Date	Conclusion	Max Conc.	Concerns
SCCS/1660/23	27 March 2024	safe with restrictions	up to 5%	Potential endocrine disrupting properties; assessed safe considering all aggregated dermal exposures

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

permitted

Max

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE ChEMBL / DailyMed SULISOBENZONE

ChEMBL Phase

Adverse Events

Bioactivity

View full pharmaceutical profile →

Frequently Asked Questions

What is the NOAEL for Sulisobenzone?

Sulisobenzone has 20 NOAEL studies in the database. The lowest reported value is 0 unitless. Source: NTP ICE endocrine.

What regulatory lists include Sulisobenzone?

Sulisobenzone appears on 8 regulatory/inventory lists including inert_ingredient; non_food_use; Pesticides, IFRA Transparency, Canada; consumer_product; Substances in Products - Canada (4/2014), and 5 more. Source: EPA CPDat.

Is Sulisobenzone used in cosmetics?

Yes, Sulisobenzone is also indexed as a cosmetic ingredient under the name Sulisobenzone (Benzophenone-4). View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for Sulisobenzone come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.

Does Sulisobenzone have different safety status in cosmetics vs industrial chemicals?

Sulisobenzone is classified GHS Danger (H315, H317, H318, H319, H335) in the chemicals database but is allowed in EU cosmetics.

Is Sulisobenzone used outside industrial chemicals?

Sulisobenzone also appears in cosmetics, pharmaceutical databases.