What is the NOAEL for Sulisobenzone?
Sulisobenzone has 49 NOAEL studies in the database. The lowest reported value is 0 unitless. Source: NTP_ICE_endocrine.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Sulisobenzone
Also known as: 2-Hydroxy-4-methoxy-5-sulfobenzophenone, Benzenesulfonic acid, 5-benzoyl-4-hydroxy-2-methoxy-, Benzophenone 4, 2-Hydroxy-4-methoxybenzophenone-5-sulfonic acid, BRN 2889165 (+3 more)
CAS 4065-45-6
Sulisobenzone (CAS 4065-45-6) is a chemical substance. Key regulatory status: REACH registered, 9 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, SCCS, ECHA REACH.
View cosmetic safety profile for Sulisobenzone (Benzophenone-4) →
Cross-Vertical Regulatory Divergence
Sulisobenzone is classified GHS Danger (H315, H317, H318, H319, H335) in the chemicals database but is allowed in EU cosmetics.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
49
SOURCE
chemical inventory jurisdictions
Regulatory lists
9
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
14 fields
Name
Sulisobenzone
CAS Number
4065-45-6
DTXSID
DTXSID2042436
Molecular Formula
C14H12O6S
InChI Key
CXVGEDCSTKKODG-UHFFFAOYSA-N
Monoisotopic Mass
308.035459
Synonyms
2-Hydroxy-4-methoxy-5-sulfobenzophenoneBenzenesulfonic acid, 5-benzoyl-4-hydroxy-2-methoxy-Benzophenone 42-Hydroxy-4-methoxybenzophenone-5-sulfonic acidBRN 2889165EINECS 223-772-2Uvinuc ms 40UNII-1W6L629B4K
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
60 records
UV stabilizerFragrance
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
9 records
| List | Keyword | Source |
|---|---|---|
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| IFRA Transparency | IFRA | IFRA |
| Canada; consumer_product; Substances in Products - Canada (4/2014) | Government of Canada | CPCat |
| children; Europe; Personal care - body hygiene - body wash | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care - hair styling and care - shampoo | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| pharmaceutical | US International Trade Commission | CPCat |
| Canada; pharmaceutical | DrugBank | DrugBank |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 49 of 49 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 59 | - | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 620 | - | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 620 | - | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 620 | - | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 620 | - | - | dermal | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 620 | - | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 620 | - | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 620 | - | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 1239 | mg/kg/day | - | - | rat | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 1239 | mg/kg/day | - | - | rat | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 1250 | mg/kg/day | - | - | rat | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 1.05 | uL/min/10^6 cells | Clint | - | Human | NTP_ICE_adme_parameters |
| =10 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| =61.7 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| 1W6L629B4K | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 1W6L629B4K | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 1W6L629B4K | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 1W6L629B4K | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 0.00942 | fraction | Fu | - | Human | NTP_ICE_adme_parameters |
| =3530 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| - | unitless | Model Score | - | - | NTP_ICE_endocrine |
| =59 | - | NOAEL | - | - | SCCS_vision_codex |
| =59 | - | NOAEL | - | - | SCCS_vision_codex |
| =59 | - | NOAEL | - | - | SCCS_vision_codex |
| =59 | - | NOAEL | - | - | SCCS_vision_codex |
| =620 | mg/kg bw/day | NOAEL | oral | rat | SCCS_vision_codex |
| =620 | - | NOAEL | - | - | SCCS_vision_codex |
| =620 | mg/kg bw/day | NOAEL | oral | rat | SCCS_vision_codex |
| =620 | - | NOAEL | - | - | SCCS_vision_codex |
| =620 | mg/kg bw/day | NOAEL | oral | rat | SCCS_vision_codex |
| =620 | - | NOAEL | - | - | SCCS_vision_codex |
| =620 | mg/kg bw/day | NOAEL | oral | rat | SCCS_vision_codex |
| =620 | - | NOAEL | - | - | SCCS_vision_codex |
| =1239 | mg/kg/day | NOAEL | - | rat | SCCS_vision_codex |
| =1239 | mg/kg bw/day | NOAEL | oral | rat | SCCS_vision_codex |
| =1239 | mg/kg/day | NOAEL | - | rat | SCCS_vision_codex |
| =1239 | mg/kg bw/day | NOAEL | oral | rat | SCCS_vision_codex |
| =1239 | mg/kg/day | NOAEL | - | rat | SCCS_vision_codex |
| =1239 | mg/kg bw/day | NOAEL | oral | rat | SCCS_vision_codex |
| =1239 | mg/kg/day | NOAEL | - | rat | SCCS_vision_codex |
| =1239 | mg/kg bw/day | NOAEL | oral | rat | SCCS_vision_codex |
| =1250 | mg/kg/day | NOAEL | - | rat | SCCS_vision_codex |
| =1250 | mg/kg/day | NOAEL | - | rat | SCCS_vision_codex |
| =1250 | mg/kg/day | NOAEL | - | rat | SCCS_vision_codex |
| =1250 | mg/kg/day | NOAEL | - | rat | SCCS_vision_codex |
| 620 | mg/kg bw/day | repeated dose toxicity | oral | rat | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 620 | mg/kg bw/day | repeated dose toxicity | oral | rat | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 1239 | mg/kg bw/day | repeated dose toxicity | oral | rat | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 1239 | mg/kg bw/day | repeated dose toxicity | oral | rat | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
Showing 49 of 49 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Sulisobenzone | 223-772-2 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
SCCS Opinions
EU Scientific Committee opinions tied to the matched substance.
SOURCE
EU SCCS
1 opinions
| Opinion | Date | Conclusion | Max Conc. | Concerns |
|---|---|---|---|---|
| SCCS/1660/23 | 27 March 2024 | safe with restrictions | up to 5% | Potential endocrine disrupting properties; assessed safe considering all aggregated dermal exposures |
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
sunscreen
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
SULISOBENZONE
ChEMBL Phase
2
Adverse Events
0
Bioactivity
3
Frequently Asked Questions
What regulatory lists include Sulisobenzone?
Sulisobenzone appears on 8 regulatory/inventory lists including inert_ingredient; non_food_use; Pesticides, IFRA Transparency, Canada; consumer_product; Substances in Products - Canada (4/2014), and 5 more. Source: EPA CPDat.
Is Sulisobenzone used in cosmetics?
Yes, Sulisobenzone is also indexed as a cosmetic ingredient under the name Sulisobenzone (Benzophenone-4). View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Sulisobenzone come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Does Sulisobenzone have different safety status in cosmetics vs industrial chemicals?
Sulisobenzone is classified GHS Danger (H315, H317, H318, H319, H335) in the chemicals database but is allowed in EU cosmetics.
Is Sulisobenzone used outside industrial chemicals?
Sulisobenzone also appears in cosmetics, pharmaceutical databases.