Sulisobenzone (Benzophenone-4)
INCI: SULISOBENZONE
Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
6 study endpoints found for Sulisobenzone (Benzophenone-4). NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =1239 mg/kg/day | oral | rat | subchronic | SCCS |
| NOAEL | 1239 mg/kg bw/day | - | - | subchronic | SCCS_PDF_extraction |
| NOAEL | 1250 mg/kg bw/day | - | - | - | SCCS_PDF_extraction |
| NOAEL | 1239 mg/kg bw/day | oral | rat | subchronic | SCCS_PDF_extraction |
| NOAEL | 620 mg/kg bw/day | oral | - | - | SCCS_PDF_extraction |
| NOAEL | 1239 mg/kg bw/day | oral | - | subchronic | SCCS_PDF_extraction |
Safety Opinions
Official safety assessments from the Scientific Committee on Consumer Safety (SCCS) and Cosmetic Ingredient Review (CIR).
ed to potential endocrine disrupting properties, the SCCS is of the opinion that benzophenone-4 is safe when used as UV filter up to a maximum concentration of 5% in sunscreen, face and hand cream, all leave-on and rinse-off products (total dermal aggregate), lipstick, sunscreen propellant spray and
ed to potential endocrine disrupting properties, the SCCS is of the opinion that benzophenone-4 is safe when used as UV filter up to a maximum concentration of 5% in sunscreen, face and hand cream, all leave-on and rinse-off products (total dermal aggregate), lipstick, sunscreen propellant spray and
ed to potential endocrine disrupting properties, the SCCS is of the opinion that benzophenone-4 is safe when used as UV filter up to a maximum concentration of 5% in sunscreen, face and hand cream, all leave-on and rinse-off products (total dermal aggregate), lipstick, sunscreen propellant spray and
ed to potential endocrine disrupting properties, the SCCS is of the opinion that benzophenone-4 is safe when used as UV filter up to a maximum concentration of 5% in sunscreen, face and hand cream, all leave-on and rinse-off products (total dermal aggregate), lipstick, sunscreen propellant spray and
ed to potential endocrine disrupting properties, the SCCS is of the opinion that benzophenone-4 is safe when used as UV filter up to a maximum concentration of 5% in sunscreen, face and hand cream, all leave-on and rinse-off products (total dermal aggregate), lipstick, sunscreen propellant spray and
Expert Verdict
Well-established UV filter with excellent safety profile; permitted in EU cosmetics.
Regulatory Flags
Frequently Asked Questions
Is Sulisobenzone (Benzophenone-4) safe in cosmetics?
Well-established UV filter with excellent safety profile; permitted in EU cosmetics. The EU classifies Sulisobenzone (Benzophenone-4) as "permitted". Safety rating: EXCELLENT. 6 toxicological study endpoint(s) are available in our database. This ingredient has been reviewed by sccs.
Is Sulisobenzone (Benzophenone-4) allowed in the EU?
Sulisobenzone (Benzophenone-4) EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Sulisobenzone (Benzophenone-4) do in cosmetics?
Sulisobenzone (Benzophenone-4) functions as: UV Filter. It is classified as a UV Filter / Sunscreen in our database. CAS number: 4065-45-6.
What is the Margin of Safety for Sulisobenzone (Benzophenone-4)?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Sulisobenzone (Benzophenone-4)?
The NOAEL (No Observed Adverse Effect Level) for Sulisobenzone (Benzophenone-4) is =1239 mg/kg/day based on a subchronic study via oral route in rat. A total of 6 study endpoints are available. Source: SCCS.
Compliance Tools
Check Sulisobenzone (Benzophenone-4) compliance across multiple jurisdictions:
Related Ingredients
Is Sulisobenzone (Benzophenone-4) in Your Products?
Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.
Try Piro Free →Analyze Your Full Ingredient List
Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Sulisobenzone (Benzophenone-4) in your formulation.