Also known as: Cyclohexane, 5-isocyanato-1-(isocyanatomethyl)-1,3,3-trimethyl-, BRN 2726467, EINECS 223-861-6, UNII-43B0856528, IPDI (+1 more)
CAS 4098-71-9
Isophorone diisocyanate (CAS 4098-71-9) is a chemical substance with GHS signal word Danger; key hazard signal: H330; H314; H318; H334; H317; H411. Key regulatory status: REACH registered, 10 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, ILO ICSC, OSHA, EPA TRI.
Isophorone diisocyanate is classified GHS Danger (H330, H314, H318, H334, H317, H411) in the chemicals database but is restricted in EU cosmetics.
CAS, identifiers, formula, and alternate names for the matched substance record.
EU harmonized hazard classification, hazard statements, pictograms, and signal word.
| Hazard Class | H-Statements | Pictograms | Signal |
|---|---|---|---|
| Acute Tox. 1; Skin Corr. 1; Eye Dam. 1; Resp. Sens. 1; Skin Sens. 1A; Aquatic Chronic 2 | H330; H314; H318; H334; H317; H411 | GHS06; GHS05; GHS08; GHS09 | Danger |
International Chemical Safety Card hazard and exposure summary.
| Field | Value |
|---|---|
| GHS Signal Word | DANGER |
| GHS Hazard Statements | Fatal if inhaled Harmful in contact with skin Causes severe skin burns and eye damage May cause allergic or asthmatic symptoms or breathing difficulties if inhaled May cause allergic skin reaction |
| Short-term Effects | The substance is corrosive to the skin. The substance is severely irritating to the eyes. The aerosol is irritating to the respiratory tract. |
| Long-term Effects | Repeated or prolonged contact may cause skin sensitization. Repeated or prolonged inhalation may cause asthma. See Notes. |
| Routes of Exposure | The substance can be absorbed into the body by inhalation of its aerosol and through the skin. |
Occupational exposure limits from OSHA, NIOSH, and ACGIH rows.
| Agency | Metric | Value | ppm | mg/m3 | Skin |
|---|---|---|---|---|---|
| NIOSH | TWA | 0.005 ppm (0.045 mg/m³) | 0.005 | 0.045 | Y |
| NIOSH | STEL | 0.02 ppm (0.180 mg/m³) | 0.02 | 0.18 | Y |
| ACGIH | TWA | 0.005 ppm [1985] | 0.005 | - | N |
| CAL/OSHA | TWA | 0.005 ppm (0.045 mg/m³) | 0.005 | 0.045 | Y |
| CAL/OSHA | STEL | 0.02 ppm | 0.02 | - | Y |
Industrial and product-use categories associated with this substance.
Inventory, screening, and regulatory list matches from public chemical databases.
| List | Keyword | Source |
|---|---|---|
| CEDI | FDA | United States Food and Drug Administration (FDA) |
| Arts and crafts/Office supplies - fabric treatment and dye; detected | Danish Environmental Protection Agency | Danish EPA |
| Indirect additives food contact (10/2018) | FDA | United States Food and Drug Administration (FDA) |
| Cons electronics mech appliances and machinery; detected; Europe | Danish EPA | Danish EPA |
| Cons electronics mech appliances and machinery; detected; Europe | Danish EPA | Danish EPA |
| Cons electronics mech appliances and machinery; detected; Europe | Danish EPA | Danish EPA |
| Cons electronics mech appliances and machinery; Europe; nondetect | Danish EPA | Danish EPA |
| detected; Europe; Toys and children's products | Danish Environmental Protection Agency | Danish EPA |
| Cons electronics mech appliances and machinery; detected; Europe | Danish EPA | Danish EPA |
| detected; Europe; Toys and children's products | Danish Environmental Protection Agency | Danish EPA |
Toxicology endpoints rendered from public NOAEL study rows.
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| range2.501 | ug/mL | CD86, EC120 | Dermal | - | NTP_ICE_skin_sensitization |
| =0.045 | mg/m3 | DNEL local | inhalation | Human | ToxValDB_GESTIS_DNEL |
| 99.8 | % | Depletion Cys | Dermal | - | NTP_ICE_skin_sensitization |
| 28.4 | % | Depletion Lys | Dermal | - | NTP_ICE_skin_sensitization |
| range318.05 | uM | EC1.5 | Dermal | - | NTP_ICE_skin_sensitization |
| 0.1 | % | EC3 | Dermal | Mouse | NTP_ICE_skin_sensitization |
| 43B0856528 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 43B0856528 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 43B0856528 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 43B0856528 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 0.031 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| 0.04 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| 0.123 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| =1000 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =4825 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =2.01 | mg/m3 | LEL | inhalation | Mouse | ToxValDB_ECHA_IUCLID |
| =3 | mg/m3 | LEL | inhalation | Mouse | ToxValDB_ECHA_IUCLID |
| =4.7 | mg/m3 | LEL | inhalation | Rat | ToxValDB_ECHA_IUCLID |
| <18 | mg/m3 | LEL | inhalation | Rat | ToxValDB_ECHA_IUCLID |
| =1.05 | mg/m3 | LOAEC | inhalation | Rat | ToxValDB_ECHA_IUCLID |
| =1.1 | mg/m3 | LOAEC | inhalation | Rat | ToxValDB_ECHA_IUCLID |
| - | unitless | Model Score | - | - | NTP_ICE_endocrine |
| =0.24 | mg/m3 | NOAEC | inhalation | Rat | ToxValDB_ECHA_IUCLID |
| =0.27 | mg/m3 | NOAEC | inhalation | Rat | ToxValDB_ECHA_IUCLID |
Showing 24 of 24 studies
Registration status from the ECHA REACH registered substances database.
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 3-isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate | 223-861-6 | ECHA overview → |
TRI hazard and reporting flags for the matched chemical.
| Chemical | Category | Flags |
|---|---|---|
| Isophorone diisocyanate (IPDI) | N120 - Diisocyanates | - |
Australian industrial chemicals inventory status and applicable conditions.
Same-CAS cosmetic ingredient record for cross-vertical context.
Same-CAS pharmaceutical records from drug and bioactivity sources.
Isophorone diisocyanate (CAS 4098-71-9) is classified under EU CLP Annex VI as Acute Tox. 1; Skin Corr. 1; Eye Dam. 1; Resp. Sens. 1; Skin Sens. 1A; Aquatic Chronic 2 with signal word Danger. Hazard statements: H330; H314; H318; H334; H317; H411. Source: EU CLP Annex VI (ECHA).
Isophorone diisocyanate has 24 NOAEL studies in the database. The lowest reported value is 0 unitless. Source: NTP_ICE_endocrine.
Isophorone diisocyanate appears on 6 regulatory/inventory lists including CEDI, Arts and crafts/Office supplies - fabric treatment and dye; detected, Indirect additives food contact (10/2018), and 3 more. Source: EPA CPDat.
Occupational exposure limits for Isophorone diisocyanate are set by NIOSH, ACGIH, CAL/OSHA. 5 limit values from official agencies are documented in the database. Source: OSHA, NIOSH, ACGIH.
Yes, Isophorone diisocyanate is also indexed as a cosmetic ingredient under the name Isophorone Diisocyanate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ILO/WHO ICSC, OSHA/NIOSH/ACGIH, EPA Toxics Release Inventory, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Isophorone diisocyanate is classified GHS Danger (H330, H314, H318, H334, H317, H411) in the chemicals database but is restricted in EU cosmetics.
Isophorone diisocyanate also appears in cosmetics, pharmaceutical databases.