Is Isophorone Diisocyanate safe in cosmetics?
Isophorone Diisocyanate has a safety rating of "POOR" in our database. EU status: restricted. US status: restricted.
Isophorone Diisocyanate
Also known as: Cyclohexane, 5-isocyanato-1-(isocyanatomethyl)-1,3,3-trimethyl-, BRN 2726467, EINECS 223-861-6, UNII-43B0856528, IPDI (+1 more)
INCI: ISOPHORONE DIISOCYANATE
Isophorone Diisocyanate (CAS 4098-71-9) is a cosmetic cosmetic ingredient functioning as Film forming (polyurethane precursor/monomer). EU Regulation 1223/2009 status: restricted; GHS signal word DANGER. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 4098-71-9 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Isophorone Diisocyanate is classified GHS Danger (H315, H317, H319, H330, H331, H334, H335, H411) in the chemicals database but is restricted in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Film forming (polyurethane precursor/monomer)
Safety Rating
POOR
Chemistry & Identifiers
IUPAC Name
5-isocyanato-1-(isocyanatomethyl)-1,3,3-trimethylcyclohexane
InChIKey
NIMLQBUJDJZYEJ-UHFFFAOYSA-N
Regulatory Status
EU EU Status
restricted
US US Status
restricted
US Notes
Permitted as polyurethane precursor; CIR Panel requires no detectable residual isocyanate in finished polyurethane
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Isophorone Diisocyanate.
Calculate MoS for your specific formulation with the MoS Calculator.
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Signal Word
DANGER
Pictograms
CorrSkullToxicCancerHealth haz
Hazard Statements
Fatal if inhaled Harmful in contact with skin Causes severe skin burns and eye damage May cause allergic or asthmatic symptoms or breathing difficulties if inhaled May cause allergic skin reaction
Short-term Exposure Effects
The substance is corrosive to the skin. The substance is severely irritating to the eyes. The aerosol is irritating to the respiratory tract.
Long-term Exposure Effects
Repeated or prolonged contact may cause skin sensitization. Repeated or prolonged inhalation may cause asthma. See Notes.
Routes of Exposure
The substance can be absorbed into the body by inhalation of its aerosol and through the skin.
EU CLP Annex VI Harmonized Classification
Legally binding harmonized classification per Regulation (EC) No 1272/2008 (CLP) Annex VI.
Signal Word
Danger
Pictograms
Acute ToxicityCorrosiveHealth HazardEnvironmental Hazard
Hazard Class and Category
Acute Tox. 1; Skin Corr. 1; Eye Dam. 1; Resp. Sens. 1; Skin Sens. 1A; Aquatic Chronic 2
Hazard Statements
- H330 Fatal if inhaled
- H314 Causes severe skin burns and eye damage
- H318 Causes serious eye damage
- H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled
- H317 May cause an allergic skin reaction
- H411 Toxic to aquatic life with long lasting effects
Specific Concentration Limits / M-factors
inhalation: ATE = 0.03 mg/L dusts or mists; Resp. Sens. 1; H334: C ≥ 0.5%; Skin Sens. 1A; H317: C ≥ 0.001%
Inserted via ATP: ATP23
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10,000 - 100,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Hazard classification: Restricted (Annex XVII)
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (3)
Carcinogen Classification
No indication of carcinogenicity to humans (not listed by IARC).
Source: Toxin and Toxin Target Database (T3DB)
ICSC Safety Card
0499
Source: ILO-WHO International Chemical Safety Cards (ICSCs)
Skin Eye Respiratory Irritation
Irritation /to/ eyes, skin, respiratory system.
Source: Hazardous Substances Data Bank (HSDB)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Chemical reaction regulator
Film former
Regulatory List Membership (1)
FDA Indirect Food Contact Additives
Expert Verdict
Expert safety assessment and concern-level summary for Isophorone Diisocyanate.
Regulatory Flags
potential-allergen
Known Synonyms
Cyclohexane, 5-isocyanato-1-(isocyanatomethyl)-1,3,3-trimethyl-
BRN 2726467
EINECS 223-861-6
UNII-43B0856528
IPDI
Isophorone diamine diisocyanate
Chemical Function
Film former
Chemical reaction regulator
Regulatory Lists
CEDI
Arts and crafts/Office supplies - fabric treatment and dye; detected
Indirect additives food contact (10/2018)
Cons electronics mech appliances and machinery; detected; Europe
Cons electronics mech appliances and machinery; detected; Europe
Cons electronics mech appliances and machinery; detected; Europe
Cons electronics mech appliances and machinery; Europe; nondetect
detected; Europe; Toys and children's products
Cons electronics mech appliances and machinery; detected; Europe
detected; Europe; Toys and children's products
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL1509442
Frequently Asked Questions
Is Isophorone Diisocyanate allowed in the EU?
Isophorone Diisocyanate EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.
What does Isophorone Diisocyanate do in cosmetics?
Isophorone Diisocyanate functions as: Film forming (polyurethane precursor/monomer). It is classified as a cosmetic ingredient in our database. CAS number: 4098-71-9.
Is Isophorone Diisocyanate classified as hazardous under GHS?
Isophorone Diisocyanate carries a GHS signal word of "DANGER". Hazard statements: Fatal if inhaled Harmful in contact with skin Causes severe skin burns and eye damage May cause allergic or asthmatic symptoms or breathing difficulties if inhaled May cause allergic skin reaction. This classification is based on the ILO/WHO International Chemical Safety Card and ECHA C&L inventory data. Note: GHS classification applies to the pure substance — at cosmetic use concentrations, hazard thresholds may not be met.
Is Isophorone Diisocyanate used outside cosmetics?
Isophorone Diisocyanate also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Isophorone Diisocyanate have different safety status in cosmetics vs industrial chemicals?
Isophorone Diisocyanate is classified GHS Danger (H315, H317, H319, H330, H331, H334, H335, H411) in the chemicals database but is restricted in EU cosmetics.
Compliance Tools
Check Isophorone Diisocyanate compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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