Isophorone Diisocyanate

Must not be present as free monomer in finished cosmetic product; CIR mandates no detectable residual isocyanate (HPLC-MS detection limit 5 ppm); REACH Entry 74 restricts diisocyanates; respiratory sensitization incidence 16–70 per 10,000 exposed workers/year The EU classifies Isophorone Diisocyanate as "restricted". Safety rating: POOR. 2 toxicological study endpoint(s) are available in our database.

Isophorone Diisocyanate EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.

Isophorone Diisocyanate functions as: Film forming (polyurethane precursor/monomer). It is classified as a cosmetic ingredient in our database. CAS number: 4098-71-9.

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

The NOAEL (No Observed Adverse Effect Level) for Isophorone Diisocyanate is 0.64 2104 based on a inhalation study via 1991 route in rat. A total of 2 study endpoints are available. Source: REACH.

Isophorone Diisocyanate carries a GHS signal word of "DANGER". Hazard statements: Fatal if inhaled Harmful in contact with skin Causes severe skin burns and eye damage May cause allergic or asthmatic symptoms or breathing difficulties if inhaled May cause allergic skin reaction. This classification is based on the ILO/WHO International Chemical Safety Card and ECHA C&L inventory data. Note: GHS classification applies to the pure substance — at cosmetic use concentrations, hazard thresholds may not be met.