What is the NOAEL for Ciclopirox olamine?
Ciclopirox olamine has 5 NOAEL studies in the database. The lowest reported value is 50MD4SB4AP UNII. Source: openFDA substances.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Ciclopirox olamine
Also known as: 2-Aminoethanol compd. with 6-cyclohexyl-1-hydroxy-4-methyl-2(1H)-pyridinone (1:1), Batrafen, Ciclopirox ethanolamine salt (1:1), Ciclopiroxolamin, Ciclopiroxolamine (+9 more)
CAS 41621-49-2
Ciclopirox olamine (CAS 41621-49-2) is a chemical substance. Key regulatory status: REACH registered, 1 regulatory/inventory list, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, ECHA REACH.
SOURCE
noael studies public
NOAEL studies
5
SOURCE
chemical inventory jurisdictions
Regulatory lists
1
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
20 fields
Name
Ciclopirox olamine
CAS Number
41621-49-2
DTXSID
DTXSID6045583
Molecular Formula
C12H17NO2.C2H7NO
InChI Key
MBRHNTMUYWQHMR-UHFFFAOYSA-N
Monoisotopic Mass
268.178693
Synonyms
2-Aminoethanol compd. with 6-cyclohexyl-1-hydroxy-4-methyl-2(1H)-pyridinone (1:1)BatrafenCiclopirox ethanolamine salt (1:1)CiclopiroxolaminCiclopiroxolamine6-Cyclohexyl-1-hydroxy-4-methyl-2(1H)-pyridinone compd. with 2-aminoethanol (1:1)6-Cyclohexyl-1-hydroxy-4-methyl-2(1H)-pyridone, 2-aminoethanol salt6-Cyclohexyl-1-hydroxy-4-methyl-2(1H)-pyridone ethanolamine saltEINECS 255-464-9NSC 336278MicoxolaminaBrumixol
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
2 records
BiocideAnti-dandruff
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
1 records
| List | Keyword | Source |
|---|---|---|
| Canada; consumer_product; Substances in Products - Canada (4/2014) | Government of Canada | CPCat |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 5 of 5 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 50MD4SB4AP | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 50MD4SB4AP | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 50MD4SB4AP | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 50MD4SB4AP | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| =2350 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
Showing 5 of 5 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 6-cyclohexyl-1-hydroxy-4-methylpyridin-2(1H)-one, compound with 2-aminoethanol (1:1) | 255-464-9 | ECHA overview → |
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
restricted
Max
-
Category
Cosmetic Ingredient
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CICLOPIROX OLAMINE
ChEMBL Phase
3
Adverse Events
212
Bioactivity
6
Frequently Asked Questions
What regulatory lists include Ciclopirox olamine?
Ciclopirox olamine appears on 1 regulatory/inventory list including Canada; consumer_product; Substances in Products - Canada (4/2014). Source: EPA CPDat.
Is Ciclopirox olamine used in cosmetics?
Yes, Ciclopirox olamine is also indexed as a cosmetic ingredient under the name Ciclopirox Olamine. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Ciclopirox olamine come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Is Ciclopirox olamine used outside industrial chemicals?
Ciclopirox olamine also appears in cosmetics, pharmaceutical databases.