Is Ciclopirox Olamine safe in cosmetics?
Ciclopirox Olamine has a safety rating of "MODERATE" in our database. EU status: restricted. US status: permitted.
Moderate
Cosmetic Ingredient
Ciclopirox Olamine
Also known as: 2-Aminoethanol compd. with 6-cyclohexyl-1-hydroxy-4-methyl-2(1H)-pyridinone (1:1), Batrafen, Ciclopirox ethanolamine salt (1:1), Ciclopiroxolamin, Ciclopiroxolamine (+9 more)
INCI: CICLOPIROX OLAMINE
Ciclopirox Olamine (CAS 41621-49-2) is a cosmetic cosmetic ingredient functioning as Anti-dandruff agent (antimicrobial/antifungal). EU Regulation 1223/2009 status: restricted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 41621-49-2 →
Auto-generated CPSR Part A draft with source citations
Function
Anti-dandruff agent (antimicrobial/antifungal)
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
2-aminoethanol;6-cyclohexyl-1-hydroxy-4-methylpyridin-2-one
InChIKey
MBRHNTMUYWQHMR-UHFFFAOYSA-N
Regulatory Status
EU EU Status
restricted
US US Status
permitted
US Notes
Permitted in cosmetics; also an OTC/Rx antifungal drug ingredient (FDA monograph)
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Ciclopirox Olamine.
Calculate MoS for your specific formulation with the MoS Calculator.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10 - 100 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Anti-dandruff
Biocide
Expert Verdict
Expert safety assessment and concern-level summary for Ciclopirox Olamine.
Known Synonyms
2-Aminoethanol compd. with 6-cyclohexyl-1-hydroxy-4-methyl-2(1H)-pyridinone (1:1)
Batrafen
Ciclopirox ethanolamine salt (1:1)
Ciclopiroxolamin
Ciclopiroxolamine
6-Cyclohexyl-1-hydroxy-4-methyl-2(1H)-pyridinone compd. with 2-aminoethanol (1:1)
6-Cyclohexyl-1-hydroxy-4-methyl-2(1H)-pyridone, 2-aminoethanol salt
6-Cyclohexyl-1-hydroxy-4-methyl-2(1H)-pyridone ethanolamine salt
EINECS 255-464-9
NSC 336278
Micoxolamina
Brumixol
6-Cyclohexyl-1-hydroxy-4-methyl-2(1H)-pyridon, 2-aminoethanol-salz
UNII-50MD4SB4AP
Chemical Function
Biocide
Anti-dandruff
Regulatory Lists
Canada; consumer_product; Substances in Products - Canada (4/2014)
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
CICLOPIROX OLAMINE
ChEMBL ID
CHEMBL242580
Max Phase
3
Adverse Event Associations
212
Frequently Asked Questions
Is Ciclopirox Olamine allowed in the EU?
Ciclopirox Olamine EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.
What does Ciclopirox Olamine do in cosmetics?
Ciclopirox Olamine functions as: Anti-dandruff agent (antimicrobial/antifungal). It is classified as a cosmetic ingredient in our database. CAS number: 41621-49-2.
Is Ciclopirox Olamine used outside cosmetics?
Ciclopirox Olamine also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Ciclopirox Olamine compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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