What is the NOAEL for Isopropylparaben?
Isopropylparaben has 4 NOAEL studies in the database. The lowest reported value is 2000 mg/kg bw/day via oral in Mouse. Source: ToxValDB ECOTOX.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Isopropylparaben
Also known as: Benzoic acid, 4-hydroxy-, 1-methylethyl ester, 1-Methylethyl-4-hydroxybenzoate, BRN 2641564, EINECS 224-069-3, 1-Methylethyl 4-hydroxybenzoate (+2 more)
CAS 4191-73-5
Isopropylparaben (CAS 4191-73-5) is a chemical substance. Key regulatory status: REACH registered, 7 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
Cross-Vertical Regulatory Divergence
Isopropylparaben is prohibited in EU cosmetics but has active industrial GHS classifications (H302, H315, H317, H318, H319).
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
NOAEL studies
NOAEL studies
4
SOURCE
Chemical inventory jurisdictions
Regulatory lists
7
SOURCE
EU CLP Annex VI
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
12 fields
Name
Isopropylparaben
CAS Number
4191-73-5
Molecular Formula
C10H12O3
InChI Key
CMHMMKSPYOOVGI-UHFFFAOYSA-N
Monoisotopic Mass
180.078644
Synonyms
Benzoic acid, 4-hydroxy-, 1-methylethyl ester1-Methylethyl-4-hydroxybenzoateBRN 2641564EINECS 224-069-31-Methylethyl 4-hydroxybenzoatep-OxybenzoesaureisopropylesterUNII-A6EOX47QK0
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
2 records
Preservative
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
7 records
| List | Keyword | Source |
|---|---|---|
| banned; Europe; Personal care | European Commission | CosIng |
| children; Europe; Personal care - general moisturizing - hand/body lotion | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care - hair styling and care - shampoo | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 4 of 4 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 4.200e+4 | nM | AC50/EC50/IC50 | - | - | NTP ICE endocrine |
| 5.600e+4 | nM | AC50/EC50/IC50 | - | - | NTP ICE endocrine |
| A6EOX47QK0 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| =2000 | mg/kg bw/day | NOEL | oral | Mouse | ToxValDB ECOTOX |
Showing 4 of 4 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Isopropyl 4-hydroxybenzoate | 224-069-3 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
prohibited
Max
-
Category
preservative
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
ChEMBL / DailyMed
ISOPROPYL 4-HYDROXYBENZOATE
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
1
Frequently Asked Questions
What regulatory lists include Isopropylparaben?
Isopropylparaben appears on 4 regulatory/inventory lists including banned; Europe; Personal care, children; Europe; Personal care - general moisturizing - hand/body lotion, children; Europe; Personal care - hair styling and care - shampoo, and 1 more. Source: EPA CPDat.
Is Isopropylparaben used in cosmetics?
Yes, Isopropylparaben is also indexed as a cosmetic ingredient under the name Isopropylparaben. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Isopropylparaben come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Does Isopropylparaben have different safety status in cosmetics vs industrial chemicals?
Isopropylparaben is prohibited in EU cosmetics but has active industrial GHS classifications (H302, H315, H317, H318, H319).
Is Isopropylparaben used outside industrial chemicals?
Isopropylparaben also appears in cosmetics, pharmaceutical databases.