Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
2 study endpoints found for Isopropylparaben. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 600 mg/kg bw/day | dermal | rat | dermal | REACH |
| NOAEL | 250 mg/kg bw/day | oral | rat | oral | REACH |
Sensitization Profile
Contact sensitization data for Isopropylparaben based on clinical patch test studies and IFRA standards.
Source: ESSCA; IVDK; SCCS/1348/10
Expert Verdict
Isopropylparaben is prohibited in the EU but permitted in the US with a favorable CIR safety assessment and adequate margin of safety.
Regulatory Flags
Frequently Asked Questions
Is Isopropylparaben safe in cosmetics?
Isopropylparaben is prohibited in the EU but permitted in the US with a favorable CIR safety assessment and adequate margin of safety. The EU classifies Isopropylparaben as "prohibited". Safety rating: GOOD. 2 toxicological study endpoint(s) are available in our database.
Is Isopropylparaben allowed in the EU?
Isopropylparaben EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does Isopropylparaben do in cosmetics?
Isopropylparaben functions as: Preservative. It is classified as a Preservative in our database. CAS number: 4191-73-5.
What is the Margin of Safety for Isopropylparaben?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Isopropylparaben?
The NOAEL (No Observed Adverse Effect Level) for Isopropylparaben is 600 mg/kg bw/day based on a dermal study via dermal route in rat. A total of 2 study endpoints are available. Source: REACH.
Compliance Tools
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Related Ingredients
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