What is the NOAEL for Isobutylparaben?
Isobutylparaben has 7 NOAEL studies in the database. The lowest reported value is 0.0058 unitless. Source: NTP ICE endocrine.
NOAEL Data
SVHC
REACH Registered
Cosmetic Ingredient
Isobutylparaben
Also known as: Isobutyl p-hydroxybenzoate, 3-10-00-00308, BRN 2642305, EINECS 224-208-8, 2-Methylpropyl 4-hydroxybenzoate (+2 more)
CAS 4247-02-3
Isobutylparaben (CAS 4247-02-3) is a chemical substance; key hazard signal: Endocrine disrupting properties (Article 57(f) - human health). Key regulatory status: SVHC Candidate List, REACH registered, 14 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, ECHA SVHC.
Cross-Vertical Regulatory Divergence
Isobutylparaben is prohibited in EU cosmetics but has active industrial GHS classifications (H315, H318).
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
NOAEL studies
NOAEL studies
7
SOURCE
Chemical inventory jurisdictions
Regulatory lists
14
SOURCE
EU CLP Annex VI
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
12 fields
Name
Isobutylparaben
CAS Number
4247-02-3
Molecular Formula
C11H14O3
InChI Key
XPJVKCRENWUEJH-UHFFFAOYSA-N
Monoisotopic Mass
194.094294
Synonyms
Isobutyl p-hydroxybenzoate3-10-00-00308BRN 2642305EINECS 224-208-82-Methylpropyl 4-hydroxybenzoatep-OxybenzoesaureisobutylesterUNII-0QQJ25X58G
Substance of Very High Concern (SVHC)
Candidate List status and reason under the ECHA REACH SVHC program.
SOURCE
ECHA
1 records
| Substance | Reason | Included |
|---|---|---|
| Isobutyl 4-hydroxybenzoate | Endocrine disrupting properties (Article 57(f) - human health) | 17-Jan-2023 |
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
15 records
BiocidePreservative
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
14 records
| List | Keyword | Source |
|---|---|---|
| nondetect; Toys and children's products | State of Washington Department of Ecology | State of Washington |
| nondetect; Toys and children's products | State of Washington Department of Ecology | State of Washington |
| detected; Toys and children's products | State of Washington Department of Ecology | State of Washington |
| detected; Toys and children's products | State of Washington Department of Ecology | State of Washington |
| detected; Toys and children's products | State of Washington Department of Ecology | State of Washington |
| detected; Toys and children's products | State of Washington Department of Ecology | State of Washington |
| nondetect; Toys and children's products | State of Washington Department of Ecology | State of Washington |
| active_ingredient; Europe; Pesticides | Commission of the European Communities | CPCat |
| Europe; Personal care - body hygiene - hand soap | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Personal care - specialized bath products - bubble bath | Danish Environmental Protection Agency | Danish EPA |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 7 of 7 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 7.600e+4 | nM | AC50/EC50/IC50 | - | - | NTP ICE endocrine |
| 1.900e+5 | nM | AC50/EC50/IC50 | - | - | NTP ICE endocrine |
| 3.100e+5 | nM | AC50/EC50/IC50 | - | - | NTP ICE endocrine |
| 0QQJ25X58G | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 2.500e+4 | nM | LEL | - | - | NTP ICE endocrine |
| =2000 | mg/kg bw/day | NOEL | oral | Mouse | ToxValDB ECOTOX |
| 0.0058 | unitless | RBA | - | - | NTP ICE endocrine |
Showing 7 of 7 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Isobutyl 4-hydroxybenzoate | 224-208-8 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
prohibited
Max
-
Category
preservative
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
ChEMBL / DailyMed
CHEMBL3182006
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
0
Frequently Asked Questions
What regulatory lists include Isobutylparaben?
Isobutylparaben appears on 6 regulatory/inventory lists including nondetect; Toys and children's products, detected; Toys and children's products, active_ingredient; Europe; Pesticides, and 3 more. Source: EPA CPDat.
Is Isobutylparaben a Substance of Very High Concern (SVHC)?
Yes, Isobutylparaben is listed on the ECHA REACH Candidate List as a Substance of Very High Concern. Reason: Endocrine disrupting properties (Article 57(f) - human health). Source: ECHA SVHC Candidate List.
Is Isobutylparaben used in cosmetics?
Yes, Isobutylparaben is also indexed as a cosmetic ingredient under the name Isobutylparaben. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Isobutylparaben come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ECHA SVHC Candidate List, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Does Isobutylparaben have different safety status in cosmetics vs industrial chemicals?
Isobutylparaben is prohibited in EU cosmetics but has active industrial GHS classifications (H315, H318).
Is Isobutylparaben used outside industrial chemicals?
Isobutylparaben also appears in cosmetics, pharmaceutical databases.