Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Sensitization Profile
Contact sensitization data for Isobutylparaben based on clinical patch test studies and IFRA standards.
Source: ESSCA; IVDK; SCCS/1348/10
Expert Verdict
Long-chain paraben prohibited from EU cosmetics and proposed for the EU REACH Candidate List as an endocrine disruptor of very high concern. Estrogenic potency increases with alkyl chain length; isobutylparaben has significantly greater endocrine activity than short-chain methylparaben or ethylparaben. Intimate care-specific concern: formulation into products with prolonged mucosal contact would magnify endocrine exposure risks.
Regulatory Flags
Frequently Asked Questions
Is Isobutylparaben safe in cosmetics?
Long-chain paraben prohibited from EU cosmetics and proposed for the EU REACH Candidate List as an endocrine disruptor of very high concern. Estrogenic potency increases with alkyl chain length; isobutylparaben has significantly greater endocrine activity than short-chain methylparaben or ethylparaben. Intimate care-specific concern: formulation into products with prolonged mucosal contact would magnify endocrine exposure risks. The EU classifies Isobutylparaben as "prohibited". Safety rating: POOR.
Is Isobutylparaben allowed in the EU?
Isobutylparaben EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does Isobutylparaben do in cosmetics?
Isobutylparaben functions as: Preservative. It is classified as a Preservative in our database. CAS number: 4247-02-3.
What is the Margin of Safety for Isobutylparaben?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
Compliance Tools
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Related Ingredients
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