NOAEL Data Cosmetic Ingredient

P-Menthane-3,8-diol

Also known as: Cyclohexanemethanol, 2-hydroxy-alpha,alpha,4-trimethyl-, 2-(2-Hydroxypropan-2-yl)-5-methylcyclohexan-1-ol, 2-Hydroxy-α,α,4-trimethylcyclohexanemethano, 1-Hydroxy-2-(1-methyl-1-hydroxyethyl)-5-methylcyclohexane, 1-Hydroxy-5-methyl-2-(1-methyl-1-hydroxyethyl)cyclohexane (+14 more)

CAS 42822-86-6

P-Menthane-3,8-diol (CAS 42822-86-6) is a chemical substance. Key regulatory status: 14 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS.

View cosmetic safety profile for Menthanediol →

Cross-Vertical Regulatory Divergence

P-Menthane-3,8-diol is classified GHS Danger (H319, H226, H318) in the chemicals database but is allowed in EU cosmetics.

SOURCE Cross-vertical comparison Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code

SOURCE noael studies public

NOAEL studies

SOURCE chemical inventory jurisdictions

Regulatory lists

SOURCE eu clp annex vi

GHS signal

Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 25 fields

Name

P-Menthane-3,8-diol

CAS Number

42822-86-6

DTXSID

DTXSID0035744

Molecular Formula

C10H20O2

InChI Key

LMXFTMYMHGYJEI-UHFFFAOYSA-N

Monoisotopic Mass

172.14633

Synonyms

Cyclohexanemethanol, 2-hydroxy-alpha,alpha,4-trimethyl-2-(2-Hydroxypropan-2-yl)-5-methylcyclohexan-1-ol2-Hydroxy-α,α,4-trimethylcyclohexanemethano1-Hydroxy-2-(1-methyl-1-hydroxyethyl)-5-methylcyclohexane1-Hydroxy-5-methyl-2-(1-methyl-1-hydroxyethyl)cyclohexane3,8-p-MenthanediolCitrepelCooling agent 38D2-hydroxy-α,α,4-trimethylcyclohexanemethanol2-Hydroxy-α,α,4-trimethylcyclohexanmethanol2-hidroxi-α,α,4-trimetilciclohexanometanolO-menthane 3,8-diol

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 8 records

Softener and conditionerFlavouring and nutrientFragrance

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 14 records

List	Keyword	Source
IFRA Transparency	IFRA	IFRA
active_ingredient; Europe; Pesticides	Commission of the European Communities	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
Europe	European Commission	Fl@vis
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)	FDA	United States Food and Drug Administration (FDA)
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	California Department of Pesticide Regulation	State of California

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 7 of 7 studies

Value	Unit	Endpoint	Route	Species	Source
6T6Z1Z1NC4	UNII	FDA UNII substance identifier	-	-	openFDA substances
6T6Z1Z1NC4	UNII	FDA UNII substance identifier	-	-	openFDA substances
6T6Z1Z1NC4	UNII	FDA UNII substance identifier	-	-	openFDA substances
6T6Z1Z1NC4	UNII	FDA UNII substance identifier	-	-	openFDA substances
-	%	Incidence of positive responses	Dermal	Human	NTP_ICE_skin_sensitization
1000	ug/cm2	Induction dose per skin area	Dermal	Human	NTP_ICE_skin_sensitization
4	unitless	Relative reliability score	Dermal	Human	NTP_ICE_skin_sensitization

Showing 7 of 7 studies

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records

Inventory Status

listed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

permitted

Max

Food Safety Data

Same-CAS food additive, ADI, and GRAS records where available.

SOURCE EFSA / FDA GRAS 1 records

ADI: No safety concern at current levels of intake when used as a flavouring agent mg/kg bw

View full food safety profile →

Cannabis Data

Same-CAS cannabis compliance and lab records where available.

SOURCE Cannabis regulatory / lab data efsa substances

1 cannabis record found in efsa substances.

View full cannabis profile →

Frequently Asked Questions

What is the NOAEL for P-Menthane-3,8-diol?

P-Menthane-3,8-diol has 7 NOAEL studies in the database. The lowest reported value is 6T6Z1Z1NC4 UNII. Source: openFDA substances.

What regulatory lists include P-Menthane-3,8-diol?

P-Menthane-3,8-diol appears on 5 regulatory/inventory lists including IFRA Transparency, active_ingredient; Europe; Pesticides, active_ingredient; Pesticides, and 2 more. Source: EPA CPDat.

Is P-Menthane-3,8-diol used in cosmetics?

Yes, P-Menthane-3,8-diol is also indexed as a cosmetic ingredient under the name Menthanediol. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for P-Menthane-3,8-diol come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, CosIng / Ingredients DB, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.

Does P-Menthane-3,8-diol have different safety status in cosmetics vs industrial chemicals?

P-Menthane-3,8-diol is classified GHS Danger (H319, H226, H318) in the chemicals database but is allowed in EU cosmetics.

Is P-Menthane-3,8-diol used outside industrial chemicals?

P-Menthane-3,8-diol also appears in cosmetics, food safety, cannabis databases.