Menthanediol

INCI: MENTHANEDIOL

CAS Number
42822-86-6
Function
Hair Conditioning, Oral Care, Skin Conditioning, Cooling Agent, Insect Repellent
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Allowed in cosmetics - no specific prohibition or restriction. Also EPA-registered as an insect repellent active (PMD) outside cosmetic classification

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Generally well tolerated; may cause skin/eye irritation at higher concentrations; not a common sensitizer; structurally close to menthol. Also known as para-menthane-3,8-diol (PMD); naturally derived from lemon eucalyptus oil (Corymbia citriodora); proven effective against mosquitoes, ticks, horseflies, and biting midges - at 20% concentration, ~4 hours protection against Anopheles gambiae; superior to citronella in comparative testing; molecular structure close to menthol, providing a coolin...

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Concern Level: Moderate

Regulatory Flags

potential-allergen ifra_fragrance fda_food_additive

Frequently Asked Questions

Is Menthanediol safe in cosmetics?

Generally well tolerated; may cause skin/eye irritation at higher concentrations; not a common sensitizer; structurally close to menthol. Also known as para-menthane-3,8-diol (PMD); naturally derived from lemon eucalyptus oil (Corymbia citriodora); proven effective against mosquitoes, ticks, horseflies, and biting midges - at 20% concentration, ~4 hours protection against Anopheles gambiae; superior to citronella in comparative testing; molecular structure close to menthol, providing a coolin... The EU classifies Menthanediol as "permitted". Safety rating: MODERATE.

Is Menthanediol allowed in the EU?

Menthanediol EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Menthanediol do in cosmetics?

Menthanediol functions as: Hair Conditioning, Oral Care, Skin Conditioning, Cooling Agent, Insect Repellent. It is classified as a cosmetic ingredient in our database. CAS number: 42822-86-6.

What is the Margin of Safety for Menthanediol?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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