What is the NOAEL for D&C Green 5?
D&C Green 5 has 25 NOAEL studies in the database. The lowest reported value is 100 mg/kg bw/day in rat. Source: Regulatory source.
NOAEL Data
REACH Registered
Cosmetic Ingredient
D&C Green 5
Also known as: D & C green No. 5, Acid Leather Green AG, Alizarin Cyanine Green, Alizarine Cyanone Green G, Alizarine Cyanone Green B (+9 more)
CAS 4403-90-1
D&C Green 5 (CAS 4403-90-1) is a chemical substance. Key regulatory status: REACH registered, 15 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, SCCS, ECHA REACH.
SOURCE
NOAEL studies
NOAEL studies
25
SOURCE
Chemical inventory jurisdictions
Regulatory lists
15
SOURCE
EU CLP Annex VI
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
19 fields
Name
D&C Green 5
CAS Number
4403-90-1
Molecular Formula
C28H22N2O8S2.2Na
InChI Key
FPAYXBWMYIMERV-UHFFFAOYSA-L
Monoisotopic Mass
624.061297
Synonyms
D & C green No. 5Acid Leather Green AGAlizarin Cyanine GreenAlizarine Cyanone Green GAlizarine Cyanone Green BAlizarine Cyanone Green GN2,2'-(1,4-Anthraquinonylenediimino)bis(5-methylbenzenesulfonic acid) disodium salt1,4-Bis(o-sulfo-p-toluino)anthraquinone, disodium saltEINECS 224-546-6NSC 41838C.I. 61 570Zelen alizarinova brilantni g-extra
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
41 records
DyeFragrance
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
15 records
| List | Keyword | Source |
|---|---|---|
| Europe; Personal care - hair coloring | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care - hair coloring | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care - hair coloring | Danish Environmental Protection Agency | Danish EPA |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| IFRA Transparency | IFRA | IFRA |
| children; Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care - body hygiene - body wash | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care - hair styling and care - shampoo | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care - specialized bath products - bubble bath | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| pharmaceutical | FDA | United States Food and Drug Administration (FDA) |
| Personal care | FDA | United States Food and Drug Administration (FDA) |
| Medical/dental | FDA | United States Food and Drug Administration (FDA) |
| SCIL (9/2019) | USEPA | Safer Chemical Ingredients List |
| Europe; Personal care; restricted | European Commission | CosIng |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 25 of 25 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 100 | mg/kg bw/day | - | - | rat | Regulatory source |
| 8J6RDU8L9X | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| >3160 | mg/kg bw | LD50 | oral | Rat | NTP ICE acute oral |
| >1.000e+4 | mg/kg bw | LD50 | oral | Rat | NTP ICE acute oral |
| 100 | mg/kg bw/day | LOAEL | oral | rat | COSMOS DB |
| =0.0004 | mg/kg bw/d | NOAEL | oral | rat | SCCS Opinion |
| =48 | mg/kg bw/d | NOAEL | oral | rat | SCCS Opinion |
| =95 | % | NOAEL | - | - | SCCS Opinion |
| =95 | mg/kg bw/d | NOAEL | oral | rat | SCCS Opinion |
| =100 | mg/kg bw/day | NOAEL | - | - | SCCS Opinion |
| =100 | mg/kg bw/day | NOAEL | - | rat | SCCS Opinion |
| =300 | mg/kg bw/day | NOAEL | - | human | SCCS Opinion |
| =1000 | mg/kg bw/day | NOAEL | oral | Rat | ECHA |
| =1000 | mg/kg bw/day | NOAEL | - | human | SCCS Opinion |
| =0.0004 | mg/kg bw/d | dermal absorption | oral | rat | Regulatory source |
| =48 | mg/kg bw/d | dermal absorption | oral | rat | Regulatory source |
| =95 | mg/kg bw/d | dermal absorption | oral | rat | Regulatory source |
| 100 | mg/kg bw/day | developmental toxicity | oral | rat | Regulatory source |
| 300 | mg/kg bw/day | developmental toxicity | - | human | Regulatory source |
| 300 | mg/kg bw/day | developmental toxicity | oral | rat | Regulatory source |
| 1000 | mg/kg bw/day | developmental toxicity | - | human | Regulatory source |
| 1000 | mg/kg bw/day | developmental toxicity | oral | rat | Regulatory source |
| 95 | % | genotoxicity | - | - | Regulatory source |
| 100 | mg/kg bw/day | genotoxicity | - | - | Regulatory source |
| 100 | mg/kg bw/day | genotoxicity | oral | rat | Regulatory source |
Showing 25 of 25 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Disodium 2,2'-(9,10-dioxoanthracene-1,4-diyldiimino)bis(5-methylsulphonate) | 224-546-6 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
SCCS Opinions
EU Scientific Committee opinions tied to the matched substance.
SOURCE
SCCS Opinion
3 opinions
| Opinion | Date | Conclusion | Max Conc. | Concerns |
|---|---|---|---|---|
| SCCS/1495/12 | 26 February 2013 | safe | 0.5% | moderate sensitiser; secondary amine; nitrosamine <50ppb |
| SCCP/0873/05 | 21 June 2005 | safe | 0.5% | sensitisation not excluded; secondary amine; nitrosamine <50ppb |
| SCCP/0879/05 | 2005-06-21 | The SCCP is of the opinion that the information submitted is insufficient to assess the safe use of the substance. | - | Complete information on the >10% impurity required; exposure data from other cosmetic products; percutaneous absorption study; teratogenicity data; additional in vitro test for chromosomal aberrations (preferably in vitro micronucleus test). |
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Colorants
Frequently Asked Questions
What regulatory lists include D&C Green 5?
D&C Green 5 appears on 12 regulatory/inventory lists including Europe; Personal care - hair coloring, inert_ingredient; non_food_use; Pesticides, IFRA Transparency, and 9 more. Source: EPA CPDat.
Is D&C Green 5 used in cosmetics?
Yes, D&C Green 5 is also indexed as a cosmetic ingredient under the name CI 61570. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for D&C Green 5 come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB. All data traces to primary regulatory sources and is updated from official government databases.
Is D&C Green 5 used outside industrial chemicals?
D&C Green 5 also appears in cosmetics databases.