What is the NOAEL for D&C Green 5?
D&C Green 5 has 54 NOAEL studies in the database. The lowest reported value is 100 mg/kg bw/day in rat. Source: UnifiedCodex:SCCS_SHADOW:beta.noael_studies.
Also known as: D & C green No. 5, Acid Leather Green AG, Alizarin Cyanine Green, Alizarine Cyanone Green G, Alizarine Cyanone Green B (+9 more)
CAS 4403-90-1
D&C Green 5 (CAS 4403-90-1) is a chemical substance. Key regulatory status: REACH registered, 15 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, SCCS, ECHA REACH.
CAS, identifiers, formula, and alternate names for the matched substance record.
Industrial and product-use categories associated with this substance.
Inventory, screening, and regulatory list matches from public chemical databases.
| List | Keyword | Source |
|---|---|---|
| Europe; Personal care - hair coloring | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care - hair coloring | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care - hair coloring | Danish Environmental Protection Agency | Danish EPA |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| IFRA Transparency | IFRA | IFRA |
| children; Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care - body hygiene - body wash | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care - hair styling and care - shampoo | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care - specialized bath products - bubble bath | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| pharmaceutical | FDA | United States Food and Drug Administration (FDA) |
| Personal care | FDA | United States Food and Drug Administration (FDA) |
| Medical/dental | FDA | United States Food and Drug Administration (FDA) |
| SCIL (9/2019) | USEPA | Safer Chemical Ingredients List |
| Europe; Personal care; restricted | European Commission | CosIng |
Toxicology endpoints rendered from public NOAEL study rows.
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 100 | mg/kg bw/day | - | - | rat | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 100 | mg/kg bw/day | - | - | rat | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 100 | mg/kg bw/day | - | - | rat | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 8J6RDU8L9X | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 8J6RDU8L9X | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 8J6RDU8L9X | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| >3160 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| >10000 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| 100 | mg/kg bw/day | LOAEL | oral | rat | COSMOS_DB |
| =0.0004 | mg/kg bw/d | NOAEL | oral | rat | SCCS_vision_codex |
| =0.0004 | mg/kg bw/d | NOAEL | oral | rat | SCCS_vision_codex |
| =0.0004 | mg/kg bw/d | NOAEL | oral | rat | SCCS_vision_codex |
| =0.0004 | mg/kg bw/d | NOAEL | oral | rat | SCCS_vision_codex |
| =48 | mg/kg bw/d | NOAEL | oral | rat | SCCS_vision_codex |
| =48 | mg/kg bw/d | NOAEL | oral | rat | SCCS_vision_codex |
| =48 | mg/kg bw/d | NOAEL | oral | rat | SCCS_vision_codex |
| =48 | mg/kg bw/d | NOAEL | oral | rat | SCCS_vision_codex |
| =95 | % | NOAEL | - | - | SCCS_vision_codex |
| =95 | mg/kg bw/d | NOAEL | oral | rat | SCCS_vision_codex |
| =95 | % | NOAEL | - | - | SCCS_vision_codex |
| =95 | mg/kg bw/d | NOAEL | oral | rat | SCCS_vision_codex |
| =95 | % | NOAEL | - | - | SCCS_vision_codex |
| =95 | mg/kg bw/d | NOAEL | oral | rat | SCCS_vision_codex |
| =95 | % | NOAEL | - | - | SCCS_vision_codex |
| =95 | mg/kg bw/d | NOAEL | oral | rat | SCCS_vision_codex |
| =100 | mg/kg bw/day | NOAEL | - | - | SCCS_vision_codex |
| =100 | mg/kg bw/day | NOAEL | - | rat | SCCS_vision_codex |
| =100 | mg/kg bw/day | NOAEL | - | - | SCCS_vision_codex |
| =100 | mg/kg bw/day | NOAEL | - | - | SCCS_vision_codex |
| =100 | mg/kg bw/day | NOAEL | - | rat | SCCS_vision_codex |
| =100 | mg/kg bw/day | NOAEL | - | rat | SCCS_vision_codex |
| =100 | mg/kg bw/day | NOAEL | - | - | SCCS_vision_codex |
| =100 | mg/kg bw/day | NOAEL | - | rat | SCCS_vision_codex |
| =300 | mg/kg bw/day | NOAEL | - | human | SCCS_vision_codex |
| =300 | mg/kg bw/day | NOAEL | - | human | SCCS_vision_codex |
| =300 | mg/kg bw/day | NOAEL | - | human | SCCS_vision_codex |
| =300 | mg/kg bw/day | NOAEL | - | human | SCCS_vision_codex |
| =1000 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =1000 | mg/kg bw/day | NOAEL | - | human | SCCS_vision_codex |
| =1000 | mg/kg bw/day | NOAEL | - | human | SCCS_vision_codex |
| =1000 | mg/kg bw/day | NOAEL | - | human | SCCS_vision_codex |
| =1000 | mg/kg bw/day | NOAEL | - | human | SCCS_vision_codex |
| =0.0004 | mg/kg bw/d | dermal absorption | oral | rat | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| =48 | mg/kg bw/d | dermal absorption | oral | rat | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| =95 | mg/kg bw/d | dermal absorption | oral | rat | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 100 | mg/kg bw/day | developmental toxicity | oral | rat | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 300 | mg/kg bw/day | developmental toxicity | - | human | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 300 | mg/kg bw/day | developmental toxicity | - | human | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 300 | mg/kg bw/day | developmental toxicity | oral | rat | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 1000 | mg/kg bw/day | developmental toxicity | - | human | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
Showing 50 of 54 studies
Registration status from the ECHA REACH registered substances database.
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Disodium 2,2'-(9,10-dioxoanthracene-1,4-diyldiimino)bis(5-methylsulphonate) | 224-546-6 | ECHA overview → |
Australian industrial chemicals inventory status and applicable conditions.
EU Scientific Committee opinions tied to the matched substance.
| Opinion | Date | Conclusion | Max Conc. | Concerns |
|---|---|---|---|---|
| SCCS/1495/12 | 26 February 2013 | safe | 0.5% | moderate sensitiser; secondary amine; nitrosamine <50ppb |
| SCCP/0873/05 | 21 June 2005 | safe | 0.5% | sensitisation not excluded; secondary amine; nitrosamine <50ppb |
Same-CAS cosmetic ingredient record for cross-vertical context.
D&C Green 5 has 54 NOAEL studies in the database. The lowest reported value is 100 mg/kg bw/day in rat. Source: UnifiedCodex:SCCS_SHADOW:beta.noael_studies.
D&C Green 5 appears on 12 regulatory/inventory lists including Europe; Personal care - hair coloring, inert_ingredient; non_food_use; Pesticides, IFRA Transparency, and 9 more. Source: EPA CPDat.
Yes, D&C Green 5 is also indexed as a cosmetic ingredient under the name CI 61570. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB. All data traces to primary regulatory sources and is updated from official government databases.
D&C Green 5 also appears in cosmetics databases.