Is CI 61570 safe in cosmetics?
CI 61570 has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted. 10 toxicological study endpoint(s) are available in our database.
CI 61570
Also known as: D & C green No. 5, Acid Leather Green AG, Alizarin Cyanine Green, Alizarine Cyanone Green G, Alizarine Cyanone Green B (+10 more)
CI 61570 (CAS 4403-90-1) is a cosmetic cosmetic ingredient functioning as Dye. NOAEL 1000 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database.
View industrial chemical safety profile for CAS 4403-90-1 →
Auto-generated CPSR Part A draft with source citations
Chemistry & Identifiers
IUPAC Name
disodium;5-methyl-2-[[4-(4-methyl-2-sulfonatoanilino)-9,10-dioxoanthracen-1-yl]amino]benzenesulfonate
InChIKey
FPAYXBWMYIMERV-UHFFFAOYSA-L
Regulatory Status
EU EU Status
permitted
US US Status
permitted
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for CI 61570.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
10 study endpoints found for CI 61570. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =0.0004 mg/kg bw/d | oral | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =0.0004 mg/kg bw/d | oral | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =0.0004 mg/kg bw/d | oral | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =0.0004 mg/kg bw/d | oral | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =48 mg/kg bw/d | oral | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =48 mg/kg bw/d | oral | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =48 mg/kg bw/d | oral | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =48 mg/kg bw/d | oral | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =95 mg/kg bw/d | oral | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =95 mg/kg bw/d | oral | rat | dermal absorption | SCCS_vision_codex |
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for CI 61570 across SCCS product categories, with measured dermal absorption where available.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10 - 100 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
EU CosIng Annex Listing
European Commission CosIng database Annex references per Regulation (EC) No 1223/2009.
Annex IV — Permitted Colorants
Product type: Green
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
SA Saudi SFDA (III - Restricted)
Product type: Hair dye substance in non-oxidative hair dye products. Max: 0,3 %.
BRIN Brazil/India Cosmetics
India: Restricted · max 0,3 %
India: Permitted Colorant
Additional Jurisdictional Restrictions (2)
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| CN | permitted_colorant | - | All cosmetics (Class 1) |
| ASEAN | permitted_colorant | - | Not eye area |
Expanded Dermal Absorption Data
Cross-database dermal penetration: EPA Dryad physics-based, Roberts Mendeley permeation, and SCCS-aggregated measured values.
Aggregated DA Values (1 records across 5 sources)
| Type | DA % | Method | Skin Model | SCCS Ref |
|---|---|---|---|---|
| measured_in_vitro | 0.02 | In vitro — flow-through diffusion cells | - | SCCS 2013 opinion (2013) |
Additional Ingredient Properties
2 property records from structured ingredient metadata.
colorant
{"Common_Name": "D&C Green No. 5", "Chemical_Name": "Alizarin Cyanine Green F", "CAS_Number": "4403-90-1", "Colorant_Type": "Synthetic Dye", "Approved_Uses": "All cosmetics", "Max_Concentration_%": "No limit", "EU_Status": "Approved", "US_FDA_Status": "Approved 21 CFR 74.205", "Notes": "Anthraquinone dye"}
colorant_formulator
{"ci_number": "61570", "ci_name": "Pigment Green 8", "color_category": "green", "color_hex_code": "#00FF00", "natural_or_synthetic": "synthetic", "organic_or_inorganic": "organic", "lake_or_dye": "pigment", "fda_approved_use": "general", "eu_approved_cosmetic": "yes", "japan_approved": "yes", "china_approved": "yes", "coverage_opacity": "transparent", "tinting_strength": "high", "lightfastness_rat…
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Dye
Fragrance
Regulatory List Membership (4)
EU Restricted for Children (Cosmetics)
IFRA Fragrance Transparency List
EPA Safer Chemical Ingredients List (SCIL)
EU CosIng Cosmetics Ingredient Database
Expert Verdict
Expert safety assessment and concern-level summary for CI 61570.
Regulatory Flags
not-for-eye-area
fda-certified
anthraquinone
water-soluble
eu_children_restricted
epa_safer_alternative
ifra_fragrance
eu_cosing_listed
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to CI 61570 by CAS number or substance name.
Studies
29
Lowest NOAEL
0.0004
Highest NOAEL
1000
Units vary across source rows: mg/kg bw/day, mg/kg bw/d
ToxValDB_ECHA_IUCLID
SCCS_vision_codex
Dermal Absorption
View details ->| Absorption % | Method | Vehicle |
|---|---|---|
| 0.02 | In vitro — flow-through diffusion cells | Typical hair dye formulation |
Known Synonyms
D & C green No. 5
Acid Leather Green AG
Alizarin Cyanine Green
Alizarine Cyanone Green G
Alizarine Cyanone Green B
Alizarine Cyanone Green GN
2,2'-(1,4-Anthraquinonylenediimino)bis(5-methylbenzenesulfonic acid) disodium salt
1,4-Bis(o-sulfo-p-toluino)anthraquinone, disodium salt
EINECS 224-546-6
NSC 41838
C.I. 61 570
Zelen alizarinova brilantni g-extra
Zelen kysela 25
UNII-8J6RDU8L9X
D&C Green 5
Chemical Function
Dye
Fragrance
Regulatory Lists
Europe; Personal care - hair coloring
Europe; Personal care - hair coloring
Europe; Personal care - hair coloring
inert_ingredient; non_food_use; Pesticides
IFRA Transparency
children; Europe; Personal care
children; Europe; Personal care - body hygiene - body wash
children; Europe; Personal care - hair styling and care - shampoo
children; Europe; Personal care - specialized bath products - bubble bath
children; Europe; Personal care
pharmaceutical
Personal care
Medical/dental
SCIL (9/2019)
Europe; Personal care; restricted
Australian Status
AICIS status: listed
Frequently Asked Questions
Is CI 61570 allowed in the EU?
CI 61570 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does CI 61570 do in cosmetics?
CI 61570 functions as: Dye. It is classified as a cosmetic ingredient in our database. CAS number: 4403-90-1.
What is the NOAEL for CI 61570?
The NOAEL (No Observed Adverse Effect Level) for CI 61570 is =0.0004 mg/kg bw/d based on a dermal absorption study via oral route in rat. A total of 10 study endpoints are available. Source: SCCS_vision_codex.
Compliance Tools
Check CI 61570 compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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