What is the GHS hazard classification for Sodium dehydroacetate?
Sodium dehydroacetate (CAS 4418-26-2) is classified under EU CLP Annex VI as Acute Tox. 4 * with signal word Warning. Hazard statements: H302. Source: EU CLP Annex VI (ECHA).
Warning
GHS07
NOAEL Data
REACH Registered
Cosmetic Ingredient
Sodium dehydroacetate
Also known as: 3-Acetyl-6-methyl-2H-pyran-2,4(3H)-dione sodium, Caswell No. 278A, Dehydroacetic acid, sodium salt, EINECS 224-580-1, EPA Pesticide Chemical Code 027802 (+8 more)
CAS 4418-26-2
Sodium dehydroacetate (CAS 4418-26-2) is a chemical substance with GHS signal word Warning; key hazard signal: H302. Key regulatory status: REACH registered, 5 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
SOURCE
NOAEL studies
NOAEL studies
10
SOURCE
Chemical inventory jurisdictions
Regulatory lists
5
SOURCE
EU CLP Annex VI
GHS signal
Warning
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
17 fields
Name
Sodium dehydroacetate
CAS Number
4418-26-2
Molecular Formula
C8H8O4.Na
InChI Key
DSOWAKKSGYUMTF-GZOLSCHFSA-M
Synonyms
3-Acetyl-6-methyl-2H-pyran-2,4(3H)-dione sodiumCaswell No. 278ADehydroacetic acid, sodium saltEINECS 224-580-1EPA Pesticide Chemical Code 0278024-Hexenoic acid, 2-acetyl-5-hydroxy-3-oxo, delta-lactone, sodium derivative3-(1-Hydroxyethylidene)-6-methyl-2H-pyran-2,4(3H)-dione, sodium salt2H-Pyran-2,4(3H)-dione, 3-acetyl-6-methyl-, ion(1-), sodium salt2H-Pyran-2,4(3H)-dione, 3-acetyl-6-methyl-, sodium saltSodium 3-acetyl-6-methyl-2H-pyran-2,4(3H)-dioneSodium 3-acetyl-6-methyl-2,4-pyrandioneKyselina dehydroacetova sodna sul
GHS / CLP Classification
EU harmonized hazard classification, hazard statements, pictograms, and signal word.
SOURCE
EU CLP Annex VI (ECHA)
1 classifications
| Hazard Class | H-Statements | Pictograms | Signal |
|---|---|---|---|
| Acute Tox. 4 * | H302 | GHS07 | Warning |
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
6 records
PreservativeDye
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
5 records
| List | Keyword | Source |
|---|---|---|
| active_ingredient; Europe; Pesticides | Commission of the European Communities | CPCat |
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 10 of 10 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 0 | uL/min/10^6 cells | Clint | - | Human | NTP ICE adme parameters |
| =10.99 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB GESTIS DNEL |
| 8W46YN971G | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 0.062 | fraction | Fu | - | Human | NTP ICE adme parameters |
| 0 | unitless | Model Score | - | - | NTP ICE endocrine |
| 46 | mg/kg bw/day | NOAEL | oral | rat | COSMOS DB |
| 50 | mg/kg bw/day | NOAEL | oral | mouse | COSMOS DB |
| 124 | mg/kg bw/day | NOAEL | oral | monkey | COSMOS DB |
| 428 | mg/kg bw/day | NOAEL | oral | rat | COSMOS DB |
| =1000 | mg/kg bw/day | NOEL | oral | Mouse | ToxValDB ECOTOX |
Showing 10 of 10 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Sodium 1-(3,4-dihydro-6-methyl-2,4-dioxo-2H-pyran-3-ylidene)ethanolate | 224-580-1 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
restricted
Max
20%
Category
preservative
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
ChEMBL / DailyMed
SODIUM DEHYDROACETATE
ChEMBL Phase
-1
Adverse Events
0
Bioactivity
0
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA
1 records
ADI: 0.6 mg/kg bw
View full food safety profile →Frequently Asked Questions
What is the NOAEL for Sodium dehydroacetate?
Sodium dehydroacetate has 10 NOAEL studies in the database. The lowest reported value is 0 uL/min/10^6 cells in Human. Source: NTP ICE adme parameters.
What regulatory lists include Sodium dehydroacetate?
Sodium dehydroacetate appears on 3 regulatory/inventory lists including active_ingredient; Europe; Pesticides, Europe; Personal care, food_additive; Substances Added to Food (formerly EAFUS) (2/2019). Source: EPA CPDat.
Is Sodium dehydroacetate used in cosmetics?
Yes, Sodium dehydroacetate is also indexed as a cosmetic ingredient under the name Sodium Dehydroacetate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Sodium dehydroacetate come from?
Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS. All data traces to primary regulatory sources and is updated from official government databases.
Is Sodium dehydroacetate used outside industrial chemicals?
Sodium dehydroacetate also appears in cosmetics, pharmaceutical, food safety databases.