Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
10 study endpoints found for Sodium Dehydroacetate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 50 mg/kg bw/day | oral | mouse | Developmental | COSMOS_DB |
| NOAEL | 428 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| NOAEL | 124 mg/kg bw/day | oral | monkey | Chronic | COSMOS_DB |
| NOAEL | 50 mg/kg bw/day | oral | rat | Developmental | COSMOS_DB |
| NOAEL | 46 mg/kg bw/day | oral | rat | Carcinogenicity | COSMOS_DB |
| LOEL | ca.300 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | ca.1000 ppm | oral | rat | oral | REACH |
| LOAEL | >=200 mg/kg bw/day | oral | monkey | oral | REACH |
| LOEL | ca.300 mg/kg bw/day | oral | - | oral | REACH |
| NOAEL | ca.1000 ppm | oral | - | oral | REACH |
Expert Verdict
Sodium Dehydroacetate is a preservative assessed safe by CIR Expert Panel for use in cosmetics at established concentration limits, with restricted use in EU (maximum 20%) and permitted status in US.
Regulatory Flags
Frequently Asked Questions
Is Sodium Dehydroacetate safe in cosmetics?
Sodium Dehydroacetate is a preservative assessed safe by CIR Expert Panel for use in cosmetics at established concentration limits, with restricted use in EU (maximum 20%) and permitted status in US. The EU classifies Sodium Dehydroacetate as "restricted". Safety rating: GOOD. 10 toxicological study endpoint(s) are available in our database.
Is Sodium Dehydroacetate allowed in the EU?
Sodium Dehydroacetate EU regulatory status: restricted. Maximum allowed concentration: 20%. This is based on EU Regulation 1223/2009 and its amendments.
What does Sodium Dehydroacetate do in cosmetics?
Sodium Dehydroacetate functions as: Preservative. It is classified as a Preservative in our database. CAS number: 4418-26-2.
What is the Margin of Safety for Sodium Dehydroacetate?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Sodium Dehydroacetate?
The NOAEL (No Observed Adverse Effect Level) for Sodium Dehydroacetate is 50 mg/kg bw/day based on a Developmental study via oral route in mouse. A total of 10 study endpoints are available. Source: COSMOS_DB.
Compliance Tools
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