What is the NOAEL for C.I. Acid Violet 43?
C.I. Acid Violet 43 has 34 NOAEL studies in the database. The lowest reported value is 1 % via oral in rat. Source: SCCS_vision_codex.
NOAEL Data
REACH Registered
Cosmetic Ingredient
C.I. Acid Violet 43
Also known as: Ahcoquinone Blue IR, EINECS 224-618-7, NSC 47721, UNII-G5UX3K0728
CAS 4430-18-6
C.I. Acid Violet 43 (CAS 4430-18-6) is a chemical substance. Key regulatory status: REACH registered, 12 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, SCCS, ECHA REACH.
Cross-Vertical Regulatory Divergence
C.I. Acid Violet 43 is classified GHS Danger (H318, H412) in the chemicals database but is restricted in EU cosmetics.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
34
SOURCE
chemical inventory jurisdictions
Regulatory lists
12
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
9 fields
Name
C.I. Acid Violet 43
CAS Number
4430-18-6
DTXSID
DTXSID6041717
Molecular Formula
C21H15NO6S.Na
InChI Key
GTKIEPUIFBBXJQ-UHFFFAOYSA-M
Synonyms
Ahcoquinone Blue IREINECS 224-618-7NSC 47721UNII-G5UX3K0728
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
24 records
DyeFragrance
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
12 records
| List | Keyword | Source |
|---|---|---|
| Europe; Personal care - hair coloring | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care - hair coloring | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care - hair coloring | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care - hair coloring | Danish Environmental Protection Agency | Danish EPA |
| IFRA Transparency | IFRA | IFRA |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| SCIL (9/2019) | USEPA | Safer Chemical Ingredients List |
| Europe; Personal care - hair styling and care - shampoo-dandruff | Danish Environmental Protection Agency | Danish EPA |
| Personal care | FDA | United States Food and Drug Administration (FDA) |
| Europe; Personal care; restricted | European Commission | CosIng |
| SCIL (9/2019) | USEPA | Safer Chemical Ingredients List |
| Europe; Personal care | European Commission | CosIng |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 34 of 34 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| >80 | % | - | dermal | rabbit | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| >80 | % | - | dermal | rabbit | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| >80 | % | - | dermal | rabbit | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 95 | % | - | oral | rat | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 95 | % | - | oral | rat | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 95 | % | - | oral | rat | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 950 | - | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 950 | - | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| G5UX3K0728 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| G5UX3K0728 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| G5UX3K0728 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| G5UX3K0728 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 27 | mg/kg bw/day | LOAEL | oral | rat | COSMOS_DB |
| =1 | % | NOAEL | oral | rat | SCCS_vision_codex |
| =1 | % | NOAEL | oral | rat | SCCS_vision_codex |
| =1 | % | NOAEL | oral | rat | SCCS_vision_codex |
| =1 | % | NOAEL | oral | rat | SCCS_vision_codex |
| >80 | % | NOAEL | dermal | rabbit | SCCS_vision_codex |
| >80 | % | NOAEL | dermal | rabbit | SCCS_vision_codex |
| >80 | % | NOAEL | dermal | rabbit | SCCS_vision_codex |
| >80 | % | NOAEL | dermal | rabbit | SCCS_vision_codex |
| =95 | % | NOAEL | oral | rat | SCCS_vision_codex |
| =95 | % | NOAEL | oral | rat | SCCS_vision_codex |
| =95 | % | NOAEL | oral | rat | SCCS_vision_codex |
| =95 | % | NOAEL | oral | rat | SCCS_vision_codex |
| =200 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =435 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =940 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =950 | - | NOAEL | - | - | SCCS_vision_codex |
| =950 | - | NOAEL | - | - | SCCS_vision_codex |
| =950 | - | NOAEL | - | - | SCCS_vision_codex |
| =950 | - | NOAEL | - | - | SCCS_vision_codex |
| 1 | % | repeated dose toxicity | oral | rat | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 1 | % | repeated dose toxicity | oral | rat | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
Showing 34 of 34 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Sodium 4-[(9,10-dihydro-4-hydroxy-9,10-dioxo-1-anthryl)amino]toluene-3-sulphonate | 224-618-7 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
SCCS Opinions
EU Scientific Committee opinions tied to the matched substance.
SOURCE
EU SCCS
2 opinions
| Opinion | Date | Conclusion | Max Conc. | Concerns |
|---|---|---|---|---|
| SCCS/1494/12 | 26 February 2013 | safe | 0.5% | sensitisation potential not excluded |
| SCCP/0916/05 | 28 March 2006 | insufficient data | - | inadequate physico-chemical characterisation; clastogenic potential unresolved |
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
restricted
Max
-
Category
Colorants
Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include C.I. Acid Violet 43?
C.I. Acid Violet 43 appears on 8 regulatory/inventory lists including Europe; Personal care - hair coloring, IFRA Transparency, inert_ingredient; non_food_use; Pesticides, and 5 more. Source: EPA CPDat.
Is C.I. Acid Violet 43 used in cosmetics?
Yes, C.I. Acid Violet 43 is also indexed as a cosmetic ingredient under the name CI 60730. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for C.I. Acid Violet 43 come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Does C.I. Acid Violet 43 have different safety status in cosmetics vs industrial chemicals?
C.I. Acid Violet 43 is classified GHS Danger (H318, H412) in the chemicals database but is restricted in EU cosmetics.
Is C.I. Acid Violet 43 used outside industrial chemicals?
C.I. Acid Violet 43 also appears in cosmetics, cannabis databases.