Also known as: Ahcoquinone Blue IR, EINECS 224-618-7, NSC 47721, UNII-G5UX3K0728
CI 60730 (CAS 4430-18-6) is a cosmetic cosmetic ingredient functioning as Colorant. NOAEL 350 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: restricted; 5 safety opinions reviewed (CIR Safety Assessment). Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
CI 60730 is classified GHS Danger (H318, H412) in the chemicals database but is restricted in EU cosmetics.
Source: Cosmetics: ingredients.eu status; Chemicals: ghs classifications.signal word/hazard statement code
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Margin of Safety, dermal absorption, and sensitization profile summaries for CI 60730.
Calculate MoS for your specific formulation with the MoS Calculator.
3 study endpoints found for CI 60730. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =200 mg/kg bw/day | oral | Rat | subchronic | ECHA |
| NOAEL | =435 mg/kg bw/day | oral | Rat | reproduction developmental | ECHA |
| NOAEL | =940 mg/kg bw/day | oral | Rat | reproduction developmental | ECHA |
Official safety assessments from the Scientific Committee on Consumer Safety (SCCS) and Cosmetic Ingredient Review (CIR).
the Panel published a safety assessment with the conclusion that Acid Violet 43 is safe for use in hair dye formulations when free of impurities, except for the following: 18% volatile matter (at 135 C) and chlorides and sulfates (calculated as sodium salts); 0.4% water-insoluble mat
the Panel published a safety assessment with the conclusion that Acid Violet 43 is safe for use in hair dye formulations when free of impurities, except for the following: 18% volatile matter (at 135 C) and chlorides and sulfates (calculated as sodium salts); 0.4% water-insoluble mat
the Panel published a safety assessment with the conclusion that Acid Violet 43 is safe for use in hair dye formulations when free of impurities, except for the following: 18% volatile matter (at 135 C) and chlorides and sulfates (calculated as sodium salts); 0.4% water-insoluble mat
the Panel published a safety assessment with the conclusion that Acid Violet 43 is safe for use in hair dye formulations when free of impurities, except for the following: 18% volatile matter (at 135 C) and chlorides and sulfates (calculated as sodium salts); 0.4% water-insoluble mat
the Panel published a safety assessment with the conclusion that Acid Violet 43 is safe for use in hair dye formulations when free of impurities, except for the following: 18% volatile matter (at 135 C) and chlorides and sulfates (calculated as sodium salts); 0.4% water-insoluble mat
Pre-calculated NOAEL → SED → MoS audit trail for CI 60730 across SCCS product categories, with measured dermal absorption where available.
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
European Commission CosIng database Annex references per Regulation (EC) No 1223/2009.
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
Cross-database dermal penetration: EPA Dryad physics-based, Roberts Mendeley permeation, and SCCS-aggregated measured values.
| Type | DA % | Method | Skin Model | SCCS Ref |
|---|---|---|---|---|
| measured | 0.33% | - | - | SCCP/0048 |
Preliminary editorial summary for CI 60730 — not a computed safety verdict. See the sourced toxicological data above.
Public NOAEL study rows linked to CI 60730 by CAS number or substance name.
| Absorption % | Method | Vehicle |
|---|---|---|
| 0.33% | - | - |
CI 60730 has a safety rating of "GOOD" in our database. EU status: restricted. US status: permitted. 3 toxicological study endpoint(s) are available in our database. This ingredient has been reviewed by CIR Safety Assessment.
CI 60730 EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.
CI 60730 functions as: Colorant. It is classified as a cosmetic ingredient in our database. CAS number: 4430-18-6.
The NOAEL (No Observed Adverse Effect Level) for CI 60730 is =200 mg/kg bw/day based on a subchronic study via oral route in Rat. A total of 3 study endpoints are available. Source: ECHA.
CI 60730 also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
CI 60730 is classified GHS Danger (H318, H412) in the chemicals database but is restricted in EU cosmetics.
Check CI 60730 compliance across multiple jurisdictions:
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