Good Cosmetic Ingredient NOAEL Data SCCS/CIR Reviewed

CI 60730

Also known as: Ahcoquinone Blue IR, EINECS 224-618-7, NSC 47721, UNII-G5UX3K0728

CI 60730 (CAS 4430-18-6) is a cosmetic cosmetic ingredient functioning as Colorant. NOAEL 350 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: restricted; 5 safety opinions reviewed (cir). Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.

View industrial chemical safety profile for CAS 4430-18-6 →

Auto-generated CPSR Part A draft with source citations

Cross-Vertical Regulatory Divergence

CI 60730 is classified GHS Danger (H318, H412) in the chemicals database but is restricted in EU cosmetics.

Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code

CAS Number

4430-18-6

View industrial chemical safety profile →

Function

Colorant

Safety Rating

GOOD

Chemistry & Identifiers

Formula

C21H14NNaO6S

MW

431.4 g/mol

EC Number

224-618-7

PubChem CID

23669622

IUPAC Name

sodium 2-[(4-hydroxy-9,10-dioxoanthracen-1-yl)amino]-5-methylbenzenesulfonate

InChIKey

GTKIEPUIFBBXJQ-UHFFFAOYSA-M

UNII: G5UX3K0728 Wikidata: Q27278805

Regulatory Status

EU EU Status restricted

US US Status permitted

US Notes FDA permanently listed as Ext. D&C Violet No. 2; permitted for externally applied cosmetics only; not permitted in lip products or eye area; batch certification required; subsidiary colors not to exceed 1%

For full compliance data across multiple jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety, dermal absorption, and sensitization profile summaries for CI 60730.

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

3 study endpoints found for CI 60730. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint	Value	Route	Species	Study Type	Source
NOAEL	=200 mg/kg bw/day	oral	Rat	subchronic	ToxValDB_ECHA_IUCLID
NOAEL	=435 mg/kg bw/day	oral	Rat	reproduction developmental	ToxValDB_ECHA_IUCLID
NOAEL	=940 mg/kg bw/day	oral	Rat	reproduction developmental	ToxValDB_ECHA_IUCLID

Safety Opinions

Official safety assessments from the Scientific Committee on Consumer Safety (SCCS) and Cosmetic Ingredient Review (CIR).

cir

Verdict: safe

NOAEL: 200 mg/kg bw/d (not specified)

the Panel published a safety assessment with the conclusion that Acid Violet 43 is safe for use in hair dye formulations when free of impurities, except for the following: 18% volatile matter (at 135 C) and chlorides and sulfates (calculated as sodium salts); 0.4% water-insoluble mat

cir

Verdict: safe

NOAEL: 1000 mg/kg bw/d (not specified)

the Panel published a safety assessment with the conclusion that Acid Violet 43 is safe for use in hair dye formulations when free of impurities, except for the following: 18% volatile matter (at 135 C) and chlorides and sulfates (calculated as sodium salts); 0.4% water-insoluble mat

cir

Verdict: safe

NOAEL: 800 mg/kg bw/d (oral)

the Panel published a safety assessment with the conclusion that Acid Violet 43 is safe for use in hair dye formulations when free of impurities, except for the following: 18% volatile matter (at 135 C) and chlorides and sulfates (calculated as sodium salts); 0.4% water-insoluble mat

cir

Verdict: safe

NOAEL: 200 mg/kg bw/d (oral)

the Panel published a safety assessment with the conclusion that Acid Violet 43 is safe for use in hair dye formulations when free of impurities, except for the following: 18% volatile matter (at 135 C) and chlorides and sulfates (calculated as sodium salts); 0.4% water-insoluble mat

cir

Verdict: safe

NOAEL: 54.4 % (oral)

the Panel published a safety assessment with the conclusion that Acid Violet 43 is safe for use in hair dye formulations when free of impurities, except for the following: 18% volatile matter (at 135 C) and chlorides and sulfates (calculated as sodium salts); 0.4% water-insoluble mat

Pre-Calculated Safety Assessment

Pre-calculated NOAEL → SED → MoS audit trail for CI 60730 across SCCS product categories, with measured dermal absorption where available.

ECHA REACH Registration

European Chemicals Agency REACH dossier and Substances of Very High Concern listing.

Registration Type

Full

Tonnage Band

10 - 100 tonnes

Substance Type

SUBSTANCE

SVHC Candidate

No

EU CosIng Annex Listing

European Commission CosIng database Annex references per Regulation (EC) No 1223/2009.

Annex IV — Permitted Colorants

Product type: Violet

Expanded Jurisdictional Detail

Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.

SA Saudi SFDA (III - Restricted)

Product type: Hair dye substance in non-oxidative hair dye products. Max: 0,5 %.

BRIN Brazil/India Cosmetics

India: Restricted · max 0,5 %

India: Permitted Colorant

Expanded Dermal Absorption Data

Cross-database dermal penetration: EPA Dryad physics-based, Roberts Mendeley permeation, and SCCS-aggregated measured values.

Aggregated DA Values (1 records across 5 sources)

Type	DA %	Method	Skin Model	SCCS Ref
measured	0.33%	-	-	SCCP/0048

Additional Ingredient Properties

2 property records from structured ingredient metadata.

colorant

{"Common_Name": "Ext. D&C Violet No. 2", "Chemical_Name": "Alizurol Purple", "CAS_Number": "4197-25-5", "Colorant_Type": "Synthetic Dye", "Approved_Uses": "External use only", "Max_Concentration_%": "No limit", "EU_Status": "Approved", "US_FDA_Status": "Approved 21 CFR 74.602", "Notes": "Not for mucous membranes"}

colorant_formulator

{"ci_number": "60730", "ci_name": "Pigment Violet 29", "color_category": "violet", "color_hex_code": "#9932CC", "natural_or_synthetic": "synthetic", "organic_or_inorganic": "organic", "lake_or_dye": "pigment", "fda_approved_use": "external_only", "eu_approved_cosmetic": "no", "japan_approved": "yes", "china_approved": "yes", "coverage_opacity": "transparent", "tinting_strength": "high", "lightfast…

Function Categories & List Membership

Cosmetic/Chemical Function Categories

Dye Fragrance

Regulatory List Membership (4)

EU Regulated in Personal Care IFRA Fragrance Transparency List EPA Safer Chemical Ingredients List (SCIL) EU CosIng Cosmetics Ingredient Database

Expert Verdict

Expert safety assessment and concern-level summary for CI 60730.

Regulatory Flags

not-for-lips not-for-eye-area fda-certified anthraquinone cir-reviewed external-use-only epa_safer_alternative ifra_fragrance eu_cosing_listed

NOAEL Studies Summary

View details ->

Public NOAEL study rows linked to CI 60730 by CAS number or substance name.

Studies

3

Lowest NOAEL

200 mg/kg bw/day

Highest NOAEL

940 mg/kg bw/day

ToxValDB_ECHA_IUCLID

Dermal Absorption

View details ->

Absorption %	Method	Vehicle
0.33%	-	-

Known Synonyms

Ahcoquinone Blue IR EINECS 224-618-7 NSC 47721 UNII-G5UX3K0728

Chemical Function

Dye Fragrance

Regulatory Lists

Europe; Personal care - hair coloring Europe; Personal care - hair coloring Europe; Personal care - hair coloring Europe; Personal care - hair coloring IFRA Transparency inert_ingredient; non_food_use; Pesticides SCIL (9/2019) Europe; Personal care - hair styling and care - shampoo-dandruff Personal care Europe; Personal care; restricted SCIL (9/2019) Europe; Personal care

Australian Status

AICIS status: listed

Frequently Asked Questions

Is CI 60730 safe in cosmetics?

CI 60730 has a safety rating of "GOOD" in our database. EU status: restricted. US status: permitted. 3 toxicological study endpoint(s) are available in our database. This ingredient has been reviewed by cir.

Is CI 60730 allowed in the EU?

CI 60730 EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.

What does CI 60730 do in cosmetics?

CI 60730 functions as: Colorant. It is classified as a cosmetic ingredient in our database. CAS number: 4430-18-6.

What is the NOAEL for CI 60730?

The NOAEL (No Observed Adverse Effect Level) for CI 60730 is =200 mg/kg bw/day based on a subchronic study via oral route in Rat. A total of 3 study endpoints are available. Source: ToxValDB_ECHA_IUCLID.

Is CI 60730 used outside cosmetics?

CI 60730 also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.

Does CI 60730 have different safety status in cosmetics vs industrial chemicals?

CI 60730 is classified GHS Danger (H318, H412) in the chemicals database but is restricted in EU cosmetics.

Compliance Tools

Check CI 60730 compliance across multiple jurisdictions:

Ingredient Decoder

Paste a full ingredient list for instant analysis

82 Allergen Checker

Check for EU declarable fragrance allergens

Substance Compliance

Check compliance across multiple jurisdictions

Calculate Margin of Safety using SCCS methodology

Heavy Metal Limits

Compare limits across jurisdictions

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