Good Cosmetic Ingredient NOAEL Data SCCS/CIR Reviewed

CI 60730

CAS Number
4430-18-6
Function
Colorant
Safety Rating
GOOD

Regulatory Status

🇪🇺 EU Status restricted
🇺🇸 US Status permitted
US Notes FDA permanently listed as Ext. D&C Violet No. 2; permitted for externally applied cosmetics only; not permitted in lip products or eye area; batch certification required; subsidiary colors not to exceed 1%

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

10 study endpoints found for CI 60730. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
LOAEL 27 mg/kg bw/day oral rat Subchronic COSMOS_DB
NOAEL 0.119 other dermal code:3484 dermal REACH
NOAEL 300 mg/kg bw/day oral rat oral REACH
NOEL 0.1 other dermal code:3483 dermal REACH
NOAEL 200 mg/kg bw/day oral rat oral REACH
LOAEL 1000 mg/kg bw/day dermal code:3484 dermal REACH
NOAEL 200 mg/kg bw/day oral rat oral REACH
NOAEL 400 mg/kg bw/day dermal code:3483 dermal REACH
NOAEL 1000 mg/kg bw/day oral rat oral REACH
NOAEL 1.5 mg/kg bw/day dermal code:3543 dermal REACH

Safety Opinions

Official safety assessments from the Scientific Committee on Consumer Safety (SCCS) and Cosmetic Ingredient Review (CIR).

cir
Verdict: safe
NOAEL: 200 mg/kg bw/d (not specified)

the Panel published a safety assessment with the conclusion that Acid Violet 43 is safe for use in hair dye formulations when free of impurities, except for the following: 18% volatile matter (at 135 C) and chlorides and sulfates (calculated as sodium salts); 0.4% water-insoluble mat

cir
Verdict: safe
NOAEL: 1000 mg/kg bw/d (not specified)

the Panel published a safety assessment with the conclusion that Acid Violet 43 is safe for use in hair dye formulations when free of impurities, except for the following: 18% volatile matter (at 135 C) and chlorides and sulfates (calculated as sodium salts); 0.4% water-insoluble mat

cir
Verdict: safe
NOAEL: 800 mg/kg bw/d (oral)

the Panel published a safety assessment with the conclusion that Acid Violet 43 is safe for use in hair dye formulations when free of impurities, except for the following: 18% volatile matter (at 135 C) and chlorides and sulfates (calculated as sodium salts); 0.4% water-insoluble mat

cir
Verdict: safe
NOAEL: 200 mg/kg bw/d (oral)

the Panel published a safety assessment with the conclusion that Acid Violet 43 is safe for use in hair dye formulations when free of impurities, except for the following: 18% volatile matter (at 135 C) and chlorides and sulfates (calculated as sodium salts); 0.4% water-insoluble mat

cir
Verdict: safe
NOAEL: 54.4 % (oral)

the Panel published a safety assessment with the conclusion that Acid Violet 43 is safe for use in hair dye formulations when free of impurities, except for the following: 18% volatile matter (at 135 C) and chlorides and sulfates (calculated as sodium salts); 0.4% water-insoluble mat

Expert Verdict

EU-restricted violet anthraquinone dye (Annex IV/88); FDA-listed as Ext. D&C Violet No. 2 for externally applied cosmetics; CIR assessed safe as used; restricted from lips and eyes; well-characterized safety profile

⚠️
Concern Level: Low

Regulatory Flags

not-for-lips not-for-eye-area fda-certified anthraquinone cir-reviewed external-use-only epa_safer_alternative ifra_fragrance eu_cosing_listed

Frequently Asked Questions

Is CI 60730 safe in cosmetics?

EU-restricted violet anthraquinone dye (Annex IV/88); FDA-listed as Ext. D&C Violet No. 2 for externally applied cosmetics; CIR assessed safe as used; restricted from lips and eyes; well-characterized safety profile The EU classifies CI 60730 as "restricted". Safety rating: GOOD. 10 toxicological study endpoint(s) are available in our database. This ingredient has been reviewed by cir.

Is CI 60730 allowed in the EU?

CI 60730 EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.

What does CI 60730 do in cosmetics?

CI 60730 functions as: Colorant. It is classified as a cosmetic ingredient in our database. CAS number: 4430-18-6.

What is the Margin of Safety for CI 60730?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for CI 60730?

The NOAEL (No Observed Adverse Effect Level) for CI 60730 is 27 mg/kg bw/day based on a Subchronic study via oral route in rat. A total of 10 study endpoints are available. Source: COSMOS_DB.

Compliance Tools

Check CI 60730 compliance across multiple jurisdictions:

🔬
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
 🧪
Substance Compliance
Check compliance across 55 jurisdictions
 🧮
MoS Calculator
Calculate Margin of Safety using SCCS methodology
 ⚗️
Heavy Metal Limits
Compare limits across jurisdictions

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