NOAEL Data Cosmetic Ingredient

Phenol, 4,4'-(4,5,6,7-tetrabromo-1,1-dioxido-3H-2,1-benzoxathiol-3-ylidene)bis[2,6-dibromo-

Also known as: EINECS 224-622-9, NSC 11236, 3',3'',5',5''-Tetrabromophenol-4,5,6,7-tetrabromosulfonephthalein, Tetrabromphenol tetrabromsulfonphthalein

CAS 4430-25-5

Phenol, 4,4'-(4,5,6,7-tetrabromo-1,1-dioxido-3H-2,1-benzoxathiol-3-ylidene)bis[2,6-dibromo- (CAS 4430-25-5) is a chemical substance. Key regulatory status: cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, SCCS.

View cosmetic safety profile for Tetrabromophenol Blue →

SOURCE NOAEL studies
NOAEL studies
30
SOURCE Chemical inventory jurisdictions
Regulatory lists
0
SOURCE EU CLP Annex VI
GHS signal
Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 9 fields
Name
Phenol, 4,4'-(4,5,6,7-tetrabromo-1,1-dioxido-3H-2,1-benzoxathiol-3-ylidene)bis[2,6-dibromo-
CAS Number
4430-25-5
Molecular Formula
C19H6Br8O5S
InChI Key
QPMIVFWZGPTDPN-UHFFFAOYSA-N
Monoisotopic Mass
977.340295
Synonyms
EINECS 224-622-9NSC 112363',3'',5',5''-Tetrabromophenol-4,5,6,7-tetrabromosulfonephthaleinTetrabromphenol tetrabromsulfonphthalein

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 1 records
Dye

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 30 of 30 studies
ValueUnitEndpointRouteSpeciesSource
3mg/kg bw/day---Regulatory source
5mg/kg bw/day---Regulatory source
5mg/kg bw/day--ratRegulatory source
5mg/kg bw/day-oralratRegulatory source
5mg/kg bw/day---Regulatory source
10mg/kg bw/day---Regulatory source
30mg/kg bw/ day--ratRegulatory source
50mg/kg bw/day---Regulatory source
50mg/kg bw/day--ratRegulatory source
50mg/kg bw/day---Regulatory source
100mg/kg bw/day---Regulatory source
S6FO6931N7UNIIFDA UNII substance identifier--openFDA substances
3mg/kg bw/dayLOAELoralratCOSMOS DB
30mg/kg bw/dayLOAELoralratCOSMOS DB
=0.00039mg/kg bwNOAELoralratSCCS Opinion
=0.00068mg/kg bwNOAELoralratSCCS Opinion
=0.0434mg/kg bw/dNOAELoralratSCCS Opinion
=0.2%NOAEL--SCCNFP Opinion
=0.9mg/kg bw/dNOAELoralratSCCS Opinion
3mg/kg bw/dayNOAELoralratCOSMOS DB
=3mg/kg bw/dayNOAELoralratSCCS Opinion
=3mg/kg bw/dayNOAEL--SCCS Opinion
=3mg/kg bw/dNOAELoralratSCCS Opinion
=3mg/kg bw/dayNOAELoralratSCCNFP Opinion
=4-NOAEL-humanSCCS Opinion
=5mg/kg bw/dayNOAEL-ratSCCS Opinion
=5mg/kg bw/dayNOAELoralratSCCS Opinion
=5mg/kg bw/dayNOAEL--SCCNFP Opinion
=10mg/kg bw/dayNOAEL--SCCS Opinion
=10mg/kg bw/dayNOAELdermal-SCCNFP Opinion

Showing 30 of 30 studies

SCCS Opinions

EU Scientific Committee opinions tied to the matched substance.

SOURCE SCCS Opinion 4 opinions
OpinionDateConclusionMax Conc.Concerns
SCCS/1610/1913 December 2019safe0.2%none noted
SCCS/1573/167 March 2017insufficient data-discrepancy between market batch and test batch
SCCS/1472/1226-27 June 2012not safe-low MoS (21); insufficient data for oxidative use
SCCS/1426/11Adopted at 15th plenary meeting of 26-27 June 2012 (Revision of 18 September 2012)Based on the data provided, the SCCS is of the opinion that the use of Tetrabromophenol Blue with a maximum on-head concentration of 0.2% in non-oxidative hair dye formulations does pose a risk to the health of the consumer due to the low Margin of Safety.0.2% (non-oxidative hair dye, on-head) — assessed and found to POSE a riskNot safe: use at max 0.2% on-head in non-oxidative hair dye poses a risk due to low Margin of Safety. INCI name misleading (mixture of octa-, hepta- and hexa-bromo phenolsulfonphthaleins, no tetrabromo homologue). No acceptable dermal absorption study under oxidative conditions provided; oxidative use cannot be assessed without adequate dermal absorption and stability data.

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB
EU Status
restricted
Max
0.2%
Category
Colorant
View full cosmetic safety profile →

Frequently Asked Questions

What is the NOAEL for Phenol, 4,4'-(4,5,6,7-tetrabromo-1,1-dioxido-3H-2,1-benzoxathiol-3-ylidene)bis[2,6-dibromo-?

Phenol, 4,4'-(4,5,6,7-tetrabromo-1,1-dioxido-3H-2,1-benzoxathiol-3-ylidene)bis[2,6-dibromo- has 30 NOAEL studies in the database. The lowest reported value is 0.00039 mg/kg bw via oral in rat. Source: SCCS Opinion.

Is Phenol, 4,4'-(4,5,6,7-tetrabromo-1,1-dioxido-3H-2,1-benzoxathiol-3-ylidene)bis[2,6-dibromo- used in cosmetics?

Yes, Phenol, 4,4'-(4,5,6,7-tetrabromo-1,1-dioxido-3H-2,1-benzoxathiol-3-ylidene)bis[2,6-dibromo- is also indexed as a cosmetic ingredient under the name Tetrabromophenol Blue. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for Phenol, 4,4'-(4,5,6,7-tetrabromo-1,1-dioxido-3H-2,1-benzoxathiol-3-ylidene)bis[2,6-dibromo- come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, CosIng / Ingredients DB. All data traces to primary regulatory sources and is updated from official government databases.

Does Phenol, 4,4'-(4,5,6,7-tetrabromo-1,1-dioxido-3H-2,1-benzoxathiol-3-ylidene)bis[2,6-dibromo- have different safety status in cosmetics vs industrial chemicals?

Phenol, 4,4'-(4,5,6,7-tetrabromo-1,1-dioxido-3H-2,1-benzoxathiol-3-ylidene)bis[2,6-dibromo- is classified GHS Danger (H318, H412) in the chemicals database but is restricted in EU cosmetics at max 0.2%.

Is Phenol, 4,4'-(4,5,6,7-tetrabromo-1,1-dioxido-3H-2,1-benzoxathiol-3-ylidene)bis[2,6-dibromo- used outside industrial chemicals?

Phenol, 4,4'-(4,5,6,7-tetrabromo-1,1-dioxido-3H-2,1-benzoxathiol-3-ylidene)bis[2,6-dibromo- also appears in cosmetics databases.