Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
3 study endpoints found for Tetrabromophenol Blue. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| LOAEL | 3 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| NOAEL | 3 mg/kg bw/day | oral | rat | Developmental | COSMOS_DB |
| LOAEL | 30 mg/kg bw/day | oral | rat | Developmental | COSMOS_DB |
Expert Verdict
Embryotoxic at higher doses (reduced fetal ossification, cardiovascular malformations); corrosive to rabbit eyes undiluted; polybrominated compound (high log Pow 5.98); oral absorption ~30%; airbrush safety data insufficient
Regulatory Flags
Frequently Asked Questions
Is Tetrabromophenol Blue safe in cosmetics?
Embryotoxic at higher doses (reduced fetal ossification, cardiovascular malformations); corrosive to rabbit eyes undiluted; polybrominated compound (high log Pow 5.98); oral absorption ~30%; airbrush safety data insufficient The EU classifies Tetrabromophenol Blue as "restricted". Safety rating: MODERATE. 3 toxicological study endpoint(s) are available in our database.
Is Tetrabromophenol Blue allowed in the EU?
Tetrabromophenol Blue EU regulatory status: restricted. Maximum allowed concentration: 0.2%. This is based on EU Regulation 1223/2009 and its amendments.
What does Tetrabromophenol Blue do in cosmetics?
Tetrabromophenol Blue functions as: Hair colorant – used in oxidative and non-oxidative hair dye formulations. It is classified as a cosmetic ingredient in our database. CAS number: 4430-25-5.
What is the Margin of Safety for Tetrabromophenol Blue?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Tetrabromophenol Blue?
The NOAEL (No Observed Adverse Effect Level) for Tetrabromophenol Blue is 3 mg/kg bw/day based on a Subchronic study via oral route in rat. A total of 3 study endpoints are available. Source: COSMOS_DB.
Compliance Tools
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Related Ingredients
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