What is the NOAEL for 1,4-Cineole?
1,4-Cineole has 8 NOAEL studies in the database. The lowest reported value is B55JTU839B UNII. Source: openFDA substances.
NOAEL Data
Cosmetic Ingredient
1,4-Cineole
Also known as: 7-Oxabicyclo[2.2.1]heptane, 1-methyl-4-(1-methylethyl)-, 5-17-01-00273, BRN 0104974, EINECS 207-428-9, FEMA No. 3658 (+5 more)
CAS 470-67-7
1,4-Cineole (CAS 470-67-7) is a chemical substance. Key regulatory status: 9 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS.
SOURCE
noael studies public
NOAEL studies
8
SOURCE
chemical inventory jurisdictions
Regulatory lists
9
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
16 fields
Name
1,4-Cineole
CAS Number
470-67-7
DTXSID
DTXSID3047396
Molecular Formula
C10H18O
InChI Key
RFFOTVCVTJUTAD-AOOOYVTPSA-N
Monoisotopic Mass
154.135765
Synonyms
7-Oxabicyclo[2.2.1]heptane, 1-methyl-4-(1-methylethyl)-5-17-01-00273BRN 0104974EINECS 207-428-9FEMA No. 3658Isocineole1-Isopropyl-4-methyl-7-oxabicyclo(2.2.1)heptane7-Oxabicyclo(2.2.1)heptane, 1-isopropyl-4-methyl-UNII-B55JTU839B1,4-Epoxy-p-menthane
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
19 records
HumectantFragranceFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
9 records
| List | Keyword | Source |
|---|---|---|
| IFRA Transparency | IFRA | IFRA |
| Europe | European Commission | Fl@vis |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| air; Cleaning products and household care - laundry and fabric treatment; detected; emissions | Elsevier | CPCat |
| air; detected; emissions; Personal care | Elsevier | CPCat |
| air; Cleaning products and household care; detected; emissions | Elsevier | CPCat |
| detected; Europe; Vehicle - car interior | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Vehicle - car interior | Danish Environmental Protection Agency | Danish EPA |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 8 of 8 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| B55JTU839B | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| B55JTU839B | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| B55JTU839B | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| B55JTU839B | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| - | % | Incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 10800 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| =3100 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| 3 | unitless | Relative reliability score | Dermal | Human | NTP_ICE_skin_sensitization |
Showing 8 of 8 studies
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Fragrance
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
ADI: No safety concern at current levels of intake when used as a flavouring agent mg/kg bw
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include 1,4-Cineole?
1,4-Cineole appears on 9 regulatory/inventory lists including IFRA Transparency, Europe, food_additive; Substances Added to Food (formerly EAFUS) (2/2019), and 6 more. Source: EPA CPDat.
Is 1,4-Cineole used in cosmetics?
Yes, 1,4-Cineole is also indexed as a cosmetic ingredient under the name Isocineole. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 1,4-Cineole come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, CosIng / Ingredients DB, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is 1,4-Cineole used outside industrial chemicals?
1,4-Cineole also appears in cosmetics, food safety, cannabis databases.