Warning GHS08GHS09 NOAEL Data REACH Registered Cosmetic Ingredient

1,1'-[Methylenedi(4,1-phenylene)]bis(2-hydroxy-2-methylpropan-1-one)

CAS 474510-57-1

1,1'-[Methylenedi(4,1-phenylene)]bis(2-hydroxy-2-methylpropan-1-one) (CAS 474510-57-1) is a chemical substance with GHS signal word Warning; key hazard signal: H373 **; H400; H410. Key regulatory status: REACH registered, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.

View cosmetic safety profile for BIS-METHANE →

SOURCE NOAEL studies
NOAEL studies
8
SOURCE Chemical inventory jurisdictions
Regulatory lists
0
SOURCE EU CLP Annex VI
GHS signal
Warning

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 5 fields
Name
1,1'-[Methylenedi(4,1-phenylene)]bis(2-hydroxy-2-methylpropan-1-one)
CAS Number
474510-57-1
Molecular Formula
C21H24O4
InChI Key
PCKZAVNWRLEHIP-UHFFFAOYSA-N
Monoisotopic Mass
340.167459

GHS / CLP Classification

EU harmonized hazard classification, hazard statements, pictograms, and signal word.

SOURCE EU CLP Annex VI (ECHA) 1 classifications
Hazard ClassH-StatementsPictogramsSignal
STOT RE 2 *; Aquatic Acute 1; Aquatic Chronic 1H373 **; H400; H410GHS08; GHS09Warning

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 2 records
UV stabilizerPhotosensitizers

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 8 of 8 studies
ValueUnitEndpointRouteSpeciesSource
=0.71mg/m3DNEL systemicinhalationHumanToxValDB GESTIS DNEL
IZJ9BVRDO7UNIIFDA UNII substance identifier--openFDA substances
>2000mg/kg bwLD50oralRatNTP ICE acute oral
<100mg/kg bw/dayLELoralRatECHA
<200mg/kg bw/dayLELoralRatECHA
=5mg/kg bw/dayNOAELoralRatECHA
=30mg/kg bw/dayNOAELoralRatECHA
=90mg/kg bw/dayNOAELoralRatECHA

Showing 8 of 8 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA 1 records
StatusNameEC NumberLink
Registered2-hydroxy-1-(4-(4-(2-hydroxy-2-methylpropionyl)benzyl)phenyl)-2-methylpropan-1-one444-860-9ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records
Inventory Status
listed_with_terms
Conditions
Specific information requirements: Obligations to provide information apply. You must tell us within 28 days if the circumstances of your importation or manufacture (introduction) are different to those in our assessment.

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
UV Filters
View full cosmetic safety profile →

Frequently Asked Questions

What is the GHS hazard classification for 1,1'-[Methylenedi(4,1-phenylene)]bis(2-hydroxy-2-methylpropan-1-one)?

1,1'-[Methylenedi(4,1-phenylene)]bis(2-hydroxy-2-methylpropan-1-one) (CAS 474510-57-1) is classified under EU CLP Annex VI as STOT RE 2 *; Aquatic Acute 1; Aquatic Chronic 1 with signal word Warning. Hazard statements: H373 **; H400; H410. Source: EU CLP Annex VI (ECHA).

What is the NOAEL for 1,1'-[Methylenedi(4,1-phenylene)]bis(2-hydroxy-2-methylpropan-1-one)?

1,1'-[Methylenedi(4,1-phenylene)]bis(2-hydroxy-2-methylpropan-1-one) has 8 NOAEL studies in the database. The lowest reported value is 0.71 mg/m3 via inhalation in Human. Source: ToxValDB GESTIS DNEL.

Is 1,1'-[Methylenedi(4,1-phenylene)]bis(2-hydroxy-2-methylpropan-1-one) used in cosmetics?

Yes, 1,1'-[Methylenedi(4,1-phenylene)]bis(2-hydroxy-2-methylpropan-1-one) is also indexed as a cosmetic ingredient under the name BIS-METHANE. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for 1,1'-[Methylenedi(4,1-phenylene)]bis(2-hydroxy-2-methylpropan-1-one) come from?

Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB. All data traces to primary regulatory sources and is updated from official government databases.

Is 1,1'-[Methylenedi(4,1-phenylene)]bis(2-hydroxy-2-methylpropan-1-one) used outside industrial chemicals?

1,1'-[Methylenedi(4,1-phenylene)]bis(2-hydroxy-2-methylpropan-1-one) also appears in cosmetics databases.