Is BIS-METHANE safe in cosmetics?
BIS-METHANE has a safety rating of "GOOD" in our database. EU status: permitted. 3 toxicological study endpoint(s) are available in our database.
BIS-METHANE
BIS-METHANE (CAS 474510-57-1) is a cosmetic cosmetic ingredient functioning as Uv Filter. Reported NOAEL =5 mg/kg bw/day in Rat (ToxValDB_ECHA_IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 474510-57-1 →
Auto-generated CPSR Part A draft with source citations
Function
Uv Filter
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
2-hydroxy-1-[4-[[4-(2-hydroxy-2-methylpropanoyl)phenyl]methyl]phenyl]-2-methylpropan-1-one
InChIKey
PCKZAVNWRLEHIP-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
Not specifically regulated
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Toxicological Studies
3 study endpoints found for BIS-METHANE. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =5 mg/kg bw/day | oral | Rat | short-term | ToxValDB_ECHA_IUCLID |
| NOAEL | =30 mg/kg bw/day | oral | Rat | short-term | ToxValDB_ECHA_IUCLID |
| NOAEL | =90 mg/kg bw/day | oral | Rat | reproduction developmental | ToxValDB_ECHA_IUCLID |
EU CLP Annex VI Harmonized Classification
Legally binding harmonized classification per Regulation (EC) No 1272/2008 (CLP) Annex VI.
Signal Word
Warning
Pictograms
Health HazardEnvironmental Hazard
Hazard Class and Category
STOT RE 2 *; Aquatic Acute 1; Aquatic Chronic 1
Hazard Statements
- H373 **
- H400 Very toxic to aquatic life
- H410 Very toxic to aquatic life with long lasting effects
Inserted via ATP: ATP01
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10 - 100 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Hazard classification: Restricted (Annex XVII)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Photosensitizers
UV stabilizer
Expert Verdict
Expert safety assessment and concern-level summary for BIS-METHANE.
Regulatory Flags
cosing-sourced
eu-permitted
uv-filter
needs-enrichment
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to BIS-METHANE by CAS number or substance name.
Studies
3
Lowest NOAEL
5 mg/kg bw/day
Highest NOAEL
90 mg/kg bw/day
ToxValDB_ECHA_IUCLID
Chemical Function
UV stabilizer
Photosensitizers
Australian Status
AICIS status: listed_with_terms
Specific information requirements: Obligations to provide information apply. You must tell us within 28 days if the circumstances of your importation or manufacture (introduction) are different to those in our assessment.
Frequently Asked Questions
Is BIS-METHANE allowed in the EU?
BIS-METHANE EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does BIS-METHANE do in cosmetics?
BIS-METHANE functions as: Uv Filter. It is classified as a cosmetic ingredient in our database. CAS number: 474510-57-1.
What is the NOAEL for BIS-METHANE?
The NOAEL (No Observed Adverse Effect Level) for BIS-METHANE is =5 mg/kg bw/day based on a short-term study via oral route in Rat. A total of 3 study endpoints are available. Source: ToxValDB_ECHA_IUCLID.
Is BIS-METHANE used outside cosmetics?
BIS-METHANE also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check BIS-METHANE compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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