NOAEL Data Cosmetic Ingredient

8-Hydroxy-3-(4-hydroxyphenyl)-3,4-dihydro-1H-2-benzopyran-1-one

Also known as: 1H-2-Benzopyran-1-one, 3,4-dihydro-8-hydroxy-3-(4-hydroxyphenyl)-, Isocoumarin, 3,4-dihydro-8-hydroxy-3-(p-hydroxyphenyl)-, 3,4-Dihydro-8-hydroxy-3-(4-hydroxyphenyl)-1H-2-benzopyran-1-one, Hydrangenol

CAS 480-47-7

8-Hydroxy-3-(4-hydroxyphenyl)-3,4-dihydro-1H-2-benzopyran-1-one (CAS 480-47-7) is a chemical substance. Key regulatory status: cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat.

View cosmetic safety profile for Hydrangenol →

SOURCE noael studies public
NOAEL studies
4
SOURCE chemical inventory jurisdictions
Regulatory lists
0
SOURCE eu clp annex vi
GHS signal
Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 10 fields
Name
8-Hydroxy-3-(4-hydroxyphenyl)-3,4-dihydro-1H-2-benzopyran-1-one
CAS Number
480-47-7
DTXSID
DTXSID20963981
Molecular Formula
C15H12O4
InChI Key
DGKDFNDHPXVXHW-UHFFFAOYSA-N
Monoisotopic Mass
256.073559
Synonyms
1H-2-Benzopyran-1-one, 3,4-dihydro-8-hydroxy-3-(4-hydroxyphenyl)-Isocoumarin, 3,4-dihydro-8-hydroxy-3-(p-hydroxyphenyl)-3,4-Dihydro-8-hydroxy-3-(4-hydroxyphenyl)-1H-2-benzopyran-1-oneHydrangenol

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 2 records
Softener and conditioner

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 4 of 4 studies
ValueUnitEndpointRouteSpeciesSource
TL8PI7PHV1UNIIFDA UNII substance identifier--openFDA substances
TL8PI7PHV1UNIIFDA UNII substance identifier--openFDA substances
TL8PI7PHV1UNIIFDA UNII substance identifier--openFDA substances
TL8PI7PHV1UNIIFDA UNII substance identifier--openFDA substances

Showing 4 of 4 studies

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB
EU Status
prohibited
Max
-
Category
Skin Conditioning
View full cosmetic safety profile →

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL HYDRANGENOL
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
0
View full pharmaceutical profile →

Frequently Asked Questions

What is the NOAEL for 8-Hydroxy-3-(4-hydroxyphenyl)-3,4-dihydro-1H-2-benzopyran-1-one?

8-Hydroxy-3-(4-hydroxyphenyl)-3,4-dihydro-1H-2-benzopyran-1-one has 4 NOAEL studies in the database. The lowest reported value is TL8PI7PHV1 UNII. Source: openFDA substances.

Is 8-Hydroxy-3-(4-hydroxyphenyl)-3,4-dihydro-1H-2-benzopyran-1-one used in cosmetics?

Yes, 8-Hydroxy-3-(4-hydroxyphenyl)-3,4-dihydro-1H-2-benzopyran-1-one is also indexed as a cosmetic ingredient under the name Hydrangenol. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for 8-Hydroxy-3-(4-hydroxyphenyl)-3,4-dihydro-1H-2-benzopyran-1-one come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.

Is 8-Hydroxy-3-(4-hydroxyphenyl)-3,4-dihydro-1H-2-benzopyran-1-one used outside industrial chemicals?

8-Hydroxy-3-(4-hydroxyphenyl)-3,4-dihydro-1H-2-benzopyran-1-one also appears in cosmetics, pharmaceutical databases.