Regulatory Status
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Safety Data
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Expert Verdict
Anti-allergic and anti-inflammatory pharmacological effects documented; structurally related to dihydrocoumarin which showed hepatocellular adenomas in mice at high chronic oral doses; genotoxicity data (Ames, in vitro micronucleus) and dermal irritation/sensitisation data recommended; use-level restriction advisable until margin of safety calculated.
Frequently Asked Questions
Is Hydrangenol safe in cosmetics?
Anti-allergic and anti-inflammatory pharmacological effects documented; structurally related to dihydrocoumarin which showed hepatocellular adenomas in mice at high chronic oral doses; genotoxicity data (Ames, in vitro micronucleus) and dermal irritation/sensitisation data recommended; use-level restriction advisable until margin of safety calculated. The EU classifies Hydrangenol as "prohibited". Safety rating: MODERATE.
Is Hydrangenol allowed in the EU?
Hydrangenol EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does Hydrangenol do in cosmetics?
Hydrangenol functions as: Skin Conditioning — bioactive dihydroisocoumarin isolated from Hydrangea spp.. It is classified as a cosmetic ingredient in our database. CAS number: 480-47-7.
What is the Margin of Safety for Hydrangenol?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
Compliance Tools
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Related Ingredients
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