What is the NOAEL for Indigo dye?
Indigo dye has 5 NOAEL studies in the database. The lowest reported value is 1G5BK41P4F UNII. Source: openFDA substances.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Indigo dye
Also known as: C.I Vat Blue 1, C.I. 73000, 2-(1,3-Dihydro-3-oxo-2H-indol-2-ylidene)-1,2- dihydro-3H-indol-3-one, 2-(3-Oxo-1,3-dihydro-2H-indol-2-ylidene)-1,2-dihydro-3H-indol-3-one, 11669 Blue (+15 more)
CAS 482-89-3
Indigo dye (CAS 482-89-3) is a chemical substance. Key regulatory status: REACH registered, 4 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
SOURCE
noael studies public
NOAEL studies
5
SOURCE
chemical inventory jurisdictions
Regulatory lists
4
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
26 fields
Name
Indigo dye
CAS Number
482-89-3
DTXSID
DTXSID3026279
Molecular Formula
C16H10N2O2
InChI Key
COHYTHOBJLSHDF-UHFFFAOYSA-N
Monoisotopic Mass
262.074228
Synonyms
C.I Vat Blue 1C.I. 730002-(1,3-Dihydro-3-oxo-2H-indol-2-ylidene)-1,2- dihydro-3H-indol-3-one2-(3-Oxo-1,3-dihydro-2H-indol-2-ylidene)-1,2-dihydro-3H-indol-3-one11669 Blue2,2'-Bis(2,3-dihydro-3-oxoindolylidene)Bezema Indigo AXX-FLC.I. Natural Blue 1D+C Blue No. 6Dystar Indigo GrIndigo Powder WIndigotin (natural)
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
4 records
DyeSurface modifier
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
4 records
| List | Keyword | Source |
|---|---|---|
| Canada; consumer_product; Substances in Products - Canada (4/2014) | Government of Canada | CPCat |
| Medical/dental | FDA | United States Food and Drug Administration (FDA) |
| Europe; Other direct contact consumer goods; residue | Danish Environmental Protection Agency | Danish EPA |
| - | Environmental Research | Published Articles |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 5 of 5 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 1G5BK41P4F | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 1G5BK41P4F | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 1G5BK41P4F | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 1G5BK41P4F | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| >5000 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
Showing 5 of 5 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 2-(1,3-dihydro-3-oxo-2H-indol-2-ylidene)-1,2-dihydro-3H-indol-3-one | 207-586-9 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
restricted
Max
-
Category
Colorants
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
1 food-safety record found.
View full food safety profile →Frequently Asked Questions
What regulatory lists include Indigo dye?
Indigo dye appears on 3 regulatory/inventory lists including Canada; consumer_product; Substances in Products - Canada (4/2014), Medical/dental, Europe; Other direct contact consumer goods; residue. Source: EPA CPDat.
Is Indigo dye used in cosmetics?
Yes, Indigo dye is also indexed as a cosmetic ingredient under the name CI 73000. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Indigo dye come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, EFSA / FDA GRAS. All data traces to primary regulatory sources and is updated from official government databases.
Is Indigo dye used outside industrial chemicals?
Indigo dye also appears in cosmetics, food safety databases.